Associate Professor — Inorganic, Bioinorganic, and Physical Inorganic Chemistry
Research and/or Creative Works
The Liptak group aims to elucidate the mechanisms of metal tetrapyrrole biosynthesis and degradation. In order to achieve these goals, we have developed diverse biochemical (recombinant protein expression, purification, and air-sensitive sample handling), spectroscopic (fluorescence, magnetic circular dichroism, and nuclear magnetic resonance), as well as computational (density functional theory, time-dependent density functional theory, and multi-reference perturbation theory) expertise.
Researchers in the Liptak group learn a variety of biochemical, spectroscopic, and computational skills in addition to management of a research project from the first experiments to journal publication. As a result, graduate student alumni have secured jobs in both academia and industry. The majority of undergraduate alumni have moved on to graduate programs in chemistry.
A. E. Schuelke-Sanchez, A. A. Stone, M.D. Liptak. "CfbA promotes insertion of cobalt and nickel into ruffled tetrapyrrole in vitro" Dalton Trans. 2020, 49, 1065-1076.
M. A. Conger, A. R. Cornetta, M.D. Liptak. "Spectroscopic evidence for electronic control of heme hydroxylation by IsdG" Inorg. Chem. 2019, 58, 15455-15465.
B. Shao, N. Stankewitz, J. A. Morris, M. D. Liptak, I. Aprahamian. "White-light emission from a structurally simple hydrazone" Chem. Comm. 2019, 55, 9551-9554.
B. Thakuri, A. B. Graves, A. Chao, S. L. Johansen, C. W. Goulding, M. D. Liptak. "The affinity of MhuD for heme is consistent with a heme degrading function in vivo" Metallomics 2018, 10, 1560-1563.
M. A. Conger, D. Pokhrel, M. D. Liptak. “Tight Binding of Heme to Staphylococcus aureus IsdG and IsdI Precludes Design of a Competitive Inhibitor” Metallomics 2017, 9, 556–563.
H. Qian, M. E. Cousins, E. H. Horak, A. Wakefield, M. D. Liptak, I. Aprahamian. “Suppression of Kasha’s Rule (SOKR): A Novel Mechanism to Explain Aggregation Induced Emission” Nature Chem. 2017, 9, 83–87.
A. B. Graves, E. H. Horak, M. D. Liptak. “Dynamic Ruffling Distortion of the Heme Substrate in Non-Canonical Heme Oxygenase Enzymes” Dalton Trans. 2016, 45, 10058–10067.
A. B. Graves, M. T. Graves, M. D. Liptak. “Measurement of Heme Ruffling Changes in MhuD Using UV/Vis Spectroscopy” J. Phys. Chem. B 2016, 120, 3844–3853.
C. L. Lockhart, M. A. Conger, D. S. Pittman, M. D. Liptak. “Hydrogen Bond Donation to the Heme Distal Ligand of Staphylococcus aureus IsdG Tunes the Electronic Structure” J. Biol. Inorg. Chem. 2015, 20, 757–770.
A. B. Graves, R. P. Morse, A. Chao, A. Iniguez, C. W. Goulding, M. D. Liptak. “Crystallographic and Spectroscopic Insights into Heme Degradation by Mycobacterium tuberculosis MhuD” Inorg. Chem. 2014, 53, 5931–5940.
Awards and Recognition
New Talent: Americas, 2016
Paul Saltman Award, 2015
Ruth Kirschstein-NRSA, 2009
Barry M. Goldwater Scholarship, 2002
Areas of Expertise and/or Research
Bioinorganic chemistry, magneto-optical spectroscopy, computational chemistry
- B.A., Hamilton College, Clinton, NY, 2003
- Ph.D., University of Wisconsin, Madison, WI, 2008
- NIH NRSA Postdoctoral Research Fellow, University of Rochester, Rochester, NY, 2008–2011
- (802) 656-0161
Innovation Hal E340
Chem 031 — General Chemistry 1 (Fall 2015, Spring 2017)
Chem 131 — Inorganic Chemistry (Spring 2018, 2020)
Chem 231 — Advanced Inorganic Chemistry (Fall 2011-2014, 2016-2019)
Chem 236 — Physical Inorganic Chemistry (Spring 2012, 2014, 2016, 2019)