Assistant Professor - Analytical Chemistry, Physical Chemistry, Biophysical Chemistry

Research and/or Creative Works

Conventional microscopy techniques probe biological processes by imaging the location of molecules in time and space. These techniques, however, lack the ability to reveal the physiochemical nature of how these molecules dynamically interact with their local environment.  This knowledge is crucial for not only understanding biological functions, but also establishing the molecular basis for human diseases.

To gain a molecular understanding of biological processes, my group is developing a technique that we call Raman Chemical Imaging.  This technique combines the chemical specificity of Raman spectroscopy, which probes environmentally-sensitive molecular vibrations, with sophisticated coherent microscopy techniques.  This method enables us to image the structural dynamics and interactions of biomolecules in their native cellular environment.   We are interested in broadly applying Raman Chemical Imaging to investigate how living cells regulate protein folding, how protein aggregates cause neurodegeneration, and how polymer-based nanoparticles deliver nucleic acids for use in gene therapies.

Publications

Awards and Recognition

2018 – Ford Foundation Postdoctoral Fellowship (Selected by the National Academy of Sciences, Engineering, and Medicine)

Areas of Expertise and/or Research

Analytical Chemistry, Physical Chemistry, Biophysics, Raman Spectroscopy, Stimulated Raman Imaging, Advanced Biological Microscopy Technique Development, Neurodegenerative diseases, Protein Folding, Characterization of Polymer/Nanoparticle Drug and Gene Delivery.

Education

  • B.S. Molecular Biology — University of Pittsburgh, 2005-2009
  • Ph.D. Molecular Biophysics and Structural Biology — University of Pittsburgh, 2009-2016
  • Postdoctoral Fellow — University of Minnesota, 2016-2020

Contact

Phone:
  • 802-656-2329
Website(s):
  1. Group Website