Tue Sep 10 2019

  • Andrea Lee; UVM Department of Microbiology & Molecular Genetics
    10:05am - 11:00am
    Innovation E105

    Host: Christopher Landry

Tue Sep 24 2019

  • Suzanne Scarlata, Worcester Polytechnic Institute
    10:05am - 11:00am
    Innovation E105

    Title: Fine-tuning calcium responses in cells generated through neurotransmitters

    Abstract:
    There are many ways that cells receive and interpret information, and one of the most important is the G protein pathway, specifically GPCR-Gαq-phospholipase Cβ. This pathway relays information from hormones and neurotransmitters outside the cell to elicit calcium signals inside the cell. These calcium signals in turn cause cell-specific responses such as movement, division or protein synthesis. While the major aspects of this signaling system are known, cells have devised methods to amplify or attenuate calcium signals depending on the environmental conditions and type of cell. This seminar will discuss some of these mechanisms.

    Host: Jianing Li

Tue Oct 01 2019

  • Andrew Kennedy, Bates College
    10:05am - 11:00am
    Innovation E105

    Title: Epigenetic-based Therapeutics to Improve Learning and Memory

    Host: Matthias Brewer

Sat Oct 05 2019

  • 38th Annual Humphrey Symposium
    8:30am - 2:00pm
    Innovation E102

    Topic: Multiscale Modeling for Chemistry and Biochemistry


    Speakers:

    Professor Charles L. Brooks III, University of Michigan

    Title: Exploring Free Energy Landscapes in pH, Chemical and Sequence Spaces


    Professor Teresa Head-Gordon, University of California Berkeley

    Title: Coarse Graining Electrons: Fast and Accurate Representations of Electrostatic Interactions


    Professor Ken A. Dill, Stony Brook University, Laufer Center for Physical and Quantitative Biology

    Title: Challenges in Reaching Bigger, Better, Faster in Physical Simulations of Proteins


    Organizers:

    Jinaing Li and Jose Madalengoitia

Thu Oct 10 2019

  • Christopher Roberts, University of Delaware
    10:05am - 11:00am
    Innovation E105

    Title: Applied biophysics to control stability and molecular interactions of therapeutic antibodies for candidate selection and formulation design


    Abstract: Therapeutic proteins are among the fastest growing segments of the pharmaceutical industry, and represent most of the current blockbuster medicines on the market. Proteins are commonly manufactured and delivered in liquid solution, and the molecular-scale interactions between proteins and their environment (and each other) dictate key biophysical properties such as solution viscosity, solubility, and multi-scale aggregation or solution micro-structure. Candidate selection for biopharmaceuticals such has therapeutic antibodies has traditionally focused only on clinical attributes such as target selectivity, in vivo half-life, and other features that may implicitly and inadvertently lead to poor biophysical properties from the perspective of manufacturability and product development. For purposes of selecting therapeutic protein candidates and product formulations, this must be balanced with the need for rapid or high-throughput approaches to allow a large range of candidates to be tested in parallel, as well as to consider both dilute and concentrated protein solutions. Advancements in coarse-grained molecular modeling and algorithms for more rapid / efficient sampling have the potential to make these predictions more routine, while also providing “design rules” that can be implemented without the need for expensive simulations. This seminar focuses on a combination of different levels or scales of molecular modeling, combined with “minimalist” experimental data, and development of design rules based on protein sequence and three-dimensional structures. This includes effects of the product formulation or manufacturing conditions, with an emphasis on antibodies and the importance of complex two-body and multi-body interactions.


    Host: Jianing Li

Tue Oct 15 2019

  • Yftah Tal Gan, University of Nevada Reno
    10:05am - 11:00am
    Innovation E105

    Title: Development of Peptide-Based Probes to Study Cell Signaling in Bacteria


    Abstract:
    Quorum sensing (QS) is a ubiquitous process in bacteria that governs many important symbiotic and pathogenic phenotypes. As such, QS has attracted considerable attention as a means to control bacterial behaviors - attenuate undesired phenotypes, and promote productive processes. Many Gram-positive bacterial species utilize peptide pheromones to induce QS responses and initiate pathogenic phenotypes, such as competence, biofilm formation and virulence factor production. We investigate the molecular mechanisms that drive signal:receptor binding while interrogating the role of QS in the competition between bacterial species. To this end, we develop peptide-based QS modulators with distinct activity profiles (selective vs. pan-species modulators; inhibitors vs. activators) to test temporal control of QS modulation in both single-species and mixed cultures.


    Host: Monika Ivancic

Tue Oct 29 2019

  • Kit Cummins, MIT
    10:05am - 11:00am
    Innovation E105

    Host: Rory Waterman

Thu Nov 07 2019

  • Andrea Markelz, University at Buffalo
    10:05am - 11:00am
    Innovation E105

    Host: Michael Ruggiero

Thu Nov 14 2019

  • Student Seminar Series
    10:05am - 11:00am
    Innovation E105

    Host: Jose Madalengoitia

Tue Nov 19 2019

  • Student Seminar Series
    10:05am - 11:00am
    Innovation E105

    Host: Jose Madalengoitia

Thu Nov 21 2019

  • Daniel Suess, MIT
    10:05am - 11:00am
    Innovation 105

    Host: Matthew Liptak

Tue Dec 03 2019

  • Student Seminar Series
    10:05am - 11:00am
    Innovation E105

    Host: Jose Madalengoitia

Thu Dec 05 2019

  • Student Seminar Series
    10:05am - 11:00am
    Innovation E105

    Host: Jose Madalengoitia

Wed Dec 11 2019

  • Student Seminar Series
    10:05am - 11:00am
    Innovation E105

    Host: Jose Madalengoitia

Thu Feb 06 2020

  • Tyler Cocker, Michigan State University
    10:05am - 11:00am
    Innovation E105

    Host: Michael Ruggiero

Tue Mar 10 2020

  • Lisa Rosenberg, University of Victoria
    10:05am - 11:00am
    Innovation E105

    Host: Rory Waterman

Thu Mar 19 2020

  • Scott Auerbach, University of Massachusetts Amherst
    10:05am - 11:00am
    Innovation E105

    Host: Jianing Li

Thu Mar 26 2020

  • Sue Stokes, Spero Therapeutics
    10:05am - 11:00am

    Host: Matthias Brewer

Thu Apr 09 2020

  • Sharon Neufeldt, Montana State University
    10:05am - 11:00am
    Innovation E105

    Host: Matthias Brewer