Thu Sep 22 2022

  • Zachary Schultz, Ohio State University
    10:05am - 11:00am
    Innovation E105

    Title: SERS: Imaging, Diagnostics, Biomedicine; Host: David Punihaole

    Abstract:
    Advances in nanotechnology enable the detection of trace molecules from the enhanced Raman signal generated at the surface of plasmonic nanoparticle. Our results illustrate details of selective molecular enhancement that enable imaging, diagnostics, and other applications in biomedicine. We have developed technology to enable super-resolution imaging of plasmonic nanoparticles, where the fluctuations in the surface enhanced Raman scattering (SERS) signal can be analyzed with localization microscopy techniques to provide nanometer spatial resolution of the emitting molecules location. We have been able to use this approach to increase the spatial resolution of SERS imaging in living cells. While we can visualize SERS fluctuations across a wide field of view, the spectral information in these experiments generally requires a second measurement after acquiring the super-resolved image. Additional work now enables the super-resolved SERS image and the corresponding spectrum to be acquired simultaneously. This spectrally resolved SERS imaging provides two spatial, a frequency dimension, and a time dimension, providing increased information characterization of molecules interacting with plasmonic nanoparticles. Increased understanding has further enabled diagnostics relevant to viral infection and are being used to provide chemical details in cancer treatment. In this presentation we will discuss the instrumentation, nanoparticles, and data illustrating the wealth of information obtainable from the Raman signals of molecules interacting with nanoparticle probes.

Thu Oct 06 2022

  • Thomas Gennett, Colorado School of Mines and HyMARC EMN
    10:05am - 11:00am
    Innovation E105

    Title: Design, synthesis and characterization of advanced hydrogen storage materials; Host: Matthias Brewer

Sat Oct 08 2022

  • Humphrey Symposium
    8:30am - 1:00pm

Thu Oct 13 2022

  • Dave Arnold, Booker and Dax (Food Science Development Co.)
    10:05am - 11:00am
    E105

    Host: Michael Ruggiero

Thu Nov 03 2022

  • Zhongyue Yang, Vanderbilt University
    10:05am - 11:00am
    Innovation E105

    Title: Automatic Enzyme Design Host: Matthias Brewer

    Abstract:
    The a priori computational design of function-enhancing enzyme mutants is significant for expanding the biocatalytic toolbox for late-stage functionalization of drug-like molecules, environmental degradation of plastics and other pollutants, and medical treatment of food allergies. In this talk, I will introduce our ongoing efforts to develop computational database, software, and workflows that facilitate the discovery of beneficial enzyme mutants for catalyzing new-to-nature reactions. This includes an integrated enzyme structure-function database, IntEnzyDB; a high-throughput enzyme modeling software, EnzyHTP; a deep learning framework for predicting the outcome of enzyme-catalyzed hydrolytic kinetic resolution, EnzyScore. We will also talk about the use of these tools to advance understanding of fundamental enzyme catalysis processes.

Thu Nov 10 2022

  • Chris Douglas, University of Minnesota
    10:05am - 11:00am
    Innovation E-105

    Title: Functionalization of Carbon Sigma Bonds: Mechanism and Applications in Synthesis; Host: Matthias Brewer

Tue Nov 15 2022

  • Katherine Willets, Temple University
    10:05am - 11:00am
    Innovation E105

    Host: David Punihaole

Tue Nov 29 2022

  • Student Seminar Series
    10:05am - 11:00am
    Innovation E105

    Host: David Punihaole

Thu Dec 01 2022

  • Student Seminar Series
    10:05am - 11:00am
    Innovation E105

    Host: David Punihaole

Tue Dec 06 2022

  • Student Seminar Series
    10:05am - 11:00am
    Innovation E105

    Host: David Punihaole

Thu Dec 08 2022

  • Student Seminar Series
    10:05am - 11:00am
    Innovation E105

    Host: David Punihaole

Tue Jan 31 2023

  • Mike McGuirk; Colorado School of Mines
    10:05am - 11:05am
    E105

    Host: Michael Ruggiero

Tue Feb 07 2023

  • Amanda Morris, Virginia Tech
    10:05am - 11:00am
    Innovation E105

    Host: Michael Ruggiero

Thu Feb 09 2023

  • Fenella France, Chief of Preservation Research and Testing Division at the Library of Congress
    10:05am - 11:00am
    E105

    Host: Yangguang Ou

Tue Feb 21 2023

  • Frank Hegmann, University of Alberta
    10:05am - 11:00am
    Innovation E105

    Host: Michael Ruggiero

Thu Mar 09 2023

  • Casey Londergan, Haverford College
    10:05am - 11:00am
    Innovation e105

    Host: David Punihaole

Tue Mar 21 2023

  • Vahe Bandarian, University of Utah
    10:05am - 11:00am
    Innovation E105

    Host: Matthew Liptak

Tue Mar 28 2023

  • Blaine Mooers, University of Oklahoma Health Sciences Center
    10:05am - 11:00am
    Innovation E105

    Host: Monika Ivancic

Tue Apr 04 2023

  • Sean Moran, Southern Illinois University
    10:05am - 11:00am
    E105

    Host: David Punihaole

Tue Apr 18 2023

  • Jennifer Lee, NIH
    10:05am - 11:00am
    E105

    Host: David Punihaole

Tue Apr 25 2023

  • Renã Robinson, Vanderbilt University
    10:05am - 11:00am
    Innovation E105

    Host: Yangguang Ou