Research

The Department of Obstetrics, Gynecology, and Reproductive Sciences conducts research for women's health, encompassing both clinical and basic science. Our work is funded by a mix of federal and private sources.

The Department supports clinical and basic research, integrating it into our educational mission, including training for Interns, Residents, and Fellows in Maternal Fetal Medicine and Reproductive Endocrinology. Our labs welcome undergraduate, graduate, post-doctoral and medical students for hands-on biomedical research experience. There are opportunities for student and patient involvement in research, along with various funding mechanisms for support.

Student Research Opportunities

OB/GYN Research Intake Form for Students

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Are you interested in gaining research experience at the Department of Obstetrics, Gynecology, and Reproductive Sciences at the University of Vermont? If you are a student at UVM, please fill out this form to indicate interest in getting involved with research in the department.

OBGYN Research Intake Form

For Undergraduate Students

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The department has opportunities for undergraduates to experience and work in an OBGYN lab for a semester.  Please reach out to an OBGYN faculty member and together draft a research plan. Please submit the plan to Dr. Nallasamy for admission into the course OBGY2995.

OBGYN LABS

Bernstein Lab

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The Bernstein Lab primary research focus is in examining the contribution of pre-pregnancy maternal phenotype to the development of preeclampsia. We evaluate anthropometric, physiologic and biochemical parameters prior to pregnancy to understand their contribution to the pathophysiology of preeclampsia. We also examine the alterations in hemostatic balance during pregnancy that are associated with both preeclampsia and other maternal conditions and increase thrombogenic risk.   

Bonney Lab

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The Bonney Lab investigates maternal immunity using mouse and human models, focusing on T cell homeostasis and its role in postpartum vascular remodeling. We study innate-adaptive immune system interactions during pregnancy and neonatal immunity. Key areas include understanding normal and preterm labor inflammation. We appreciate our global collaborations, funding sources, and contributions from friends, students, and trainees.

Kallen Lab

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The Kallen Lab studies regulatory mechanisms in ovarian follicular development and reproductive aging, focusing on noncoding RNAs (ncRNAs) as key tissue regulators. Dr. Kallen, during her Reproductive Endocrinology and Infertility fellowship, participated in the NICHD's Reproductive Scientist Development Program (RSDP), which enhances skills for physician-scientists to tackle significant issues in obstetrics and gynecology, merging her medical background with cellular and molecular research.

Nallasamy Lab

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The Nallasamy Laboratory’s primary focus is on elucidating the structural and functional aspects of the extracellular matrix (ECM) in the uterus during pregnancy and parturition. The laboratory’s research areas encompass the following key objectives:

  • ECM Reorganization During Endometrial Decidualization: This research aims to investigate the contributions of fibrillar collagen and the lysyl oxidase enzyme family to the process of decidualization and angiogenesis within the endometrium.
  • ECM-Mediated Myometrial Tissue Mechanical Homeostasis During Pregnancy and Parturition: This research aims to elucidate the roles of fibrillar collagen and lysyl oxidases in preserving the structural integrity and mechanical function of the myometrium throughout pregnancy and labor.

The Nallasamy Laboratory predominantly employs transgenic mouse models to address pivotal questions in reproductive biology. These models serve as potent tools for investigating the pathophysiology of fertility, infertility, and pregnancy-related complications. Ultimately, the laboratory’s objectives are to provide insights that will inform therapeutic strategies aimed at enhancing reproductive outcomes.