(Surgery)

Publications

Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury
A Mughal, AM Sackheim, M Sancho, TA Longden, S Russell, W Lockette, ...
Journal of Cerebral Blood Flow & Metabolism 41 (6), 1313-1327 4 2021

An oropharyngeal device for airway management of conscious and semiconscious patients: A randomized clinical trial
K Freeman, ZD Miller, RR Herrington, NT Dreyfus, P Buttaravoli, ...
Journal of the American College of Emergency Physicians Open 2 (2), e12440  2021

Traumatic brain injury impairs systemic vascular function through disruption of inward-rectifier potassium channels
AM Sackheim, N Villalba, M Sancho, OF Harraz, AD Bonev, ...
Function 2 (3), zqab018 1 2021

Traumatic Brain Injury Impairs Systemic Vascular Function Through Altered Lipid Metabolism and Disruption of Inward-Rectifier Potassium (Kir2. 1) Channels
AM Sackheim, N Villalba, M Sancho, OF Harraz, AD Bonev, ...
bioRxiv  2021

Thrombin Formation
BA Bouchard, K Freeman
Trauma Induced Coagulopathy, 77-84  2021

Examination of Factor V and Its Degradation Products in Patients with Burn Injury
JW Keyloun, MC Bravo, T Orfeo, K Freeman, KB Ziedens, S Nisar, ...
Journal of the American College of Surgeons 231 (4), S315-S316  2020

Actin is associated with tissue injury in trauma patients and produces a hypercoagulable profile in vitro
JR Coleman, EE Moore, K Freeman, ND Grubinger, GW Hennig, ...
Journal of Trauma and Acute Care Surgery 89 (1), 87-95 4 2020

A NOVEL MECHANISM TO NEUTRALIZE CIRCULATING HISTONES AND PREVENT PULMONARY ENDOTHELIAL CELL ICAM-1 EXPRESSION, NEUTROPHIL INFILTRATION, AND EDEMA IN HISTONE INFUSION AND ACUTE …
N Villalba, A Sackheim, BA Bouchard, ZD Miller, YT Ma, J Li, JL Ather, ...
SHOCK 53, 123-124  2020

DISRUPTION OF INSIDE-OUT SIGNALING BETWEEN CAPILLARIES AND UPSTREAM ARTERIOLES AFTER TRAUMATIC BRAIN INJURY IS DUE TO A PERVASIVE ENDOTHELIAL INWARD RECTIFIER POTASSIUM …
A Sackheim, A Mughal, M Sancho, TA Longden, A Sidwell, F Uhlig, ...
SHOCK 53, 113-113  2020

METFORMIN DECREASES ENDOTHELIAL HISTONE-INDUCED CALCIUM EVENTS IN MOUSE MESENTERIC ARTERIES
ND Grubinger, G Hennig, A Sackheim, D Majumdar, BA Bouchard, ...
SHOCK 53, 116-116  2020

HISTONES AND LPS PRODUCE ENDOTHELIAL INJURY THROUGH DISTINCT MECHANISMS
ZD Miller, K Malone, E Giddings, A Sackheim, ND Grubinger, ...
SHOCK 53, 128-129  2020

IDENTIFICATION OF REGULATORS OF HISTONE-MEDIATED ENDOTHELIAL DYSFUNCTION BY CRISPR SCREEN
D Majumdar, K Freeman
SHOCK 53, 114-114  2020

Dense and dangerous: The tissue plasminogen activator-resistant fibrinolysis shutdown phenotype is due to abnormal fibrin polymerization
N Dow, JR Coleman, H Moore, ZT Osborn, AM Sackheim, G Hennig, ...
The journal of trauma and acute care surgery 88 (2), 258 3 2020

Diagnostic performance of carbon monoxide testing by pulse oximetry in the emergency department
N Villalba, ZT Osborn, PR Derickson, CT Manning, RR Herrington, ...
Respiratory care 64 (11), 1351-1357 4 2019

Accuracy of point-of-care testing for anemia in the emergency department
ZT Osborn, N Villalba, PR Derickson, TP Sewatsky, AP Wager, K Freeman
Respiratory care 64 (11), 1343-1350 8 2019

Assessment of coagulation homeostasis in blunt, penetrating, and thermal trauma: guidance for a multicenter systems biology approach
JW Shupp, KE Brummel-Ziedins, MJ Cohen, K Freeman, R Hammamieh, ...
Shock (Augusta, Ga.) 52 (1 Suppl), 84 4 2019

Myogenic tone contributes to the regulation of permeability in mesenteric microvessels
L Haines, N Villalba, AM Sackheim, DM Collier, K Freeman
Microvascular research 125, 103873  2019

Vascular Biology and Microcirculation: Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium …
DM Collier, N Villalba, A Sackheim, AD Bonev, ZD Miller, JS Moore, ...
American Journal of Physiology-Heart and Circulatory Physiology 316 (6), H1309  2019

SURAMIN NEUTRALIZES CYTOTOXIC HISTONES AND PREVENTS VASCULAR INJURY, EDEMA, AND DEATH
NV Isabel, AM Sackheim, L Haines, YT Ma, J Li, JL Ather, ME Poynter, ...
SHOCK 51 (6), 55-56  2019

TRAUMATIC BRAIN INJURY IMPAIRS CEREBRAL BLOOD FLOW REGULATION THROUGH DISRUPTION OF INSIDE-OUT SIGNALING BETWEEN CAPILLARIES AND UPSTREAM ARTERIOLES
K Freeman, TA Longden, A Mughal, M Boucher, AM Sackheim, S Russell, ...
SHOCK 51 (6), 104-104  2019

Awards and Recognition

Safety Partner Award (2015)
Junior Research Award (2012)
James E. Demeules Surgical Research Award (2011)

Associations and Affiliations

Academic Appointments

  • Associate Professor, Department of Pharmacology, The Larner College of Medicine, University of Vermont, Burlington, VT (2019-present)
  • Associate Professor, Division of Surgical Research, Department of Surgery, The Larner College of Medicine, University of Vermont, Burlington, VT (2019-present)
  • Assistant Professor, Department of Pharmacology, The Larner College of Medicine, University of Vermont, Burlington, VT (2012-2019)
  • Assistant Professor, Division of Surgical Research, Department of Surgery, The Larner College of Medicine, University of Vermont, Burlington, VT (2011-2019)
  • Research Assistant Professor, Division of Surgical Research,  Department of Surgery, College of Medicine, University of Vermont, Burlington, VT (2007-2011)

Areas of Expertise and/or Research

Surgery

Education

  • Residency Emergency Medicine, Boston University
  • Internship Surgery, University of Colorado
  • Ph.D., Molecular Biology, University of Colorado
  • M.D., Medical Scientist Training Program, University of Colorado
  • B.S., Celluar & Molecular Biology, University of Michigan

Contact

Phone:
  • 1 802 656 3410
Office Location:

Larner COM Given E301A

Office Hours:

Upon Request

Website(s):
  1. Google Profile
  2. Lab Page