Research

The Department of Molecular Physiology and Biophysics (MPBP) at at Larner is the leading center for muscle and non-muscle cell motility research in the U.S. It also specializes in protein molecular structure, with expertise in high-resolution 3D electron microscopy.

The department boasts a world-class reputation with advanced labs for single molecule studies, confocal microscopy, protein crystallization, molecular biology, and transgenic research. It features interconnected labs, offices, and multimedia-equipped labs. Our research is well funded, in recognition of its world-class reputation. 

Faculty Research Interests

Cardiovascular Biology

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NameTopic(s) of Interest
Matthew CaporizzoCardiac mechanics, remodelling in heart failure and therapeutic targets.
David MaughanMuscle Biophysics, Proteomics, Sacromeric, and Metabolic Diseases
Bradley PalmerContraction and Relaxation Function in Cardiac Muscle
Michael PrevisCardiac Myosin Binding Protein-C and Cardiomyopathies
Kathleen TrybusMolecular Motors and Their Tracks
David Warshaw Myosin Molecular Motors 

Cellular Dynamics and Energetics

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NameTopic(s) of Interest
David MaughanMuscle Biophysics, Proteomics, Sarcometric and Metabolic Diseases 
Shane NelsonMyosin V Vesicle Transport in COS-7 Cells
John SalogiannisMicrotubule-based transport in health and disease.

Cytoskeleton and Molecular Motors

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NameTopic(s) of Interest
M. Yusuf AliCouples Myosin VA Motor Communication During Cargo Transport
Christopher BergerMolecular Mechanisms of Axonal Transport
Matt CaporizzoCardiac mechanics, remodelling in heart failure and therapeutic targets
Matthew HannafordCentrosomes and Cell Polarity
Hailong LuMolecular Motor Proteins
Bradley PalmerContraction and Relaxation Function in Cardiac Muscle
Michael PrevisCardiac Myosin Binding Protein-C and Cardiomyopathies
John SalogiannisMicrotubule-based transport in health and disease.
Jason StumpffMolecular Control of Cell Division
Kathleen TrybusMolecular Motors and their Tracks
David WarshawMyosin Molecular Motors

Structural and Computational Biology

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NameTopic(s) of Interest
Christopher BergerMolecular Mechanisms of Axonal Transport
David MaughanMuscle Biophysics, Proteomics, Sarcometric and Metabolic Diseases
Mark RouldX-Ray Crystallographic Analysis of Protein-Ligand Interactions
Kathleen TrybusMolecular Motors and their Tracks
David WarshawMyosin Molecular Motors
man looking into a complex looking microscope

Larner Cores and Infrastructure

Larner is home to an array of core facilities and infrastructure that support the faculty in their research endeavors. Within the department, an extensive computational infrastructure in the department and University supports theoretical studies of protein energetics, kinetics, and structure.

Larner Research Cores and Infrastructure