Assistant Professor

Doiron earned a M.S. and Ph.D. in biomedical engineering from the University of Texas at Austin and was the T. Chen Fong Postdoctoral Fellow in radiology and chemical engineering at the University of Calgary in Alberta, Canada. She was also the chief scientific officer at NanoPulse Biosciences, a startup company focused on biomedical applications of gold nanoparticles, for four years. Her research focuses on the development of nanoparticles for use in drug delivery and as contrast agents in magnetic resonance imaging in addition to studying toxicity mechanisms of nanoparticles. Applications of her work focus on detection and treatment of atherosclerosis, biofilm infections, cancer, and corneal keratitis.

Publications

Goldstein, D., Han, C., Mahan, M., Doiron, A.L. (2019). Design of
core–shell gold-coated superparamagnetic nanoparticles as a theranostic for
targeted magnetic resonance imaging and photoablation therapy. Micro & Nano
Letters. doi:10.1049/mnl.2019.0051

Goodwine, J., Gil, J., Doiron, A., Valdes, J., Solis, M., Higa, A., Davis,
S., Sauer, K. (2019). Pyruvate-depleting conditions induce biofilm dispersion
and enhance the efficacy of antibiotics in killing biofilms in vitro and in
vivo. Scientific Reports, 9(1):3763. doi: 10.1038/s41598-019-40378-z

Gomez-Garcia, J., Doiron, A.L., Steele R., Labouta, H.I., Vafadar, B.,
Shepherd R.D., Gates, I.D., Cramb, D.T., Childs S., Rinker K.D. (2018).
Nanoparticle Localization in Blood vessels: Dependence on fluid shear stress,
flow disturbances, and flow-induced changes in endothelial physiology.
Nanoscale, 10, 15249-15261. doi: 10.1039/C8NR03440K

Yoo, E., Liu, Y., Nwasike, C., Weith, A., Cordovez, B., Earhart, C., Doiron,
A.L. (2018). Surface characterization of nanoparticles using near field light
scattering. Beilstein Journal of Nanotechnology, 9, 1228–1238.
doi:10.3762/bjnano.9.114.

Liu, Y., Yoo, E., Han, C., Mahler, G., Doiron, A.L. (2018). Endothelial
Barrier Dysfunction Induced by Nanoparticle Exposure Through Actin Remodeling
via Caveolae/Raft-Regulated Calcium Signaling. NanoImpact 11:82-91. doi:
10.1016/j.impact.2018.02.007

Mahan, M.M. and Doiron, A.L. (2018). Gold Nanoparticles as X-ray, CT, and
Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology.
Journal of Nanomaterials vol. 2018, Article ID 5837276, doi:
10.1155/2018/5837276.

Liu, Y., Rogel, N., Harada, K., Jarret, L., Maiorana, C.H., German, G.K.,
Mahler, G., Doiron, A.L. (2017). Nanoparticle Size-Specific Actin
Rearrangement and Barrier Dysfunction of Endothelial Cells. Nanotoxicology,
11(7):846-856. doi: 10.1080/17435390.2017.1371349; PMID: 28885066.

Yoo, E., Cheng, H.A., Nardacci, L.E., Beaman, D., Lee, C., Fishbein, K.W.,
Spencer, R.G.S., Fisher, O.Z., Doiron, A.L. (2017). Activatable Interpolymer
Complex-Superparamagnetic Iron Oxide Nanoparticles as Magnetic Resonance
Contrast Agents Sensitive to Oxidative Stress. Colloids and Surfaces B:
Biointerfaces, 158: 578-588. doi: 10.1016/j.colsurfb.2017.07.025; PMID:
28750340.

Areas of Expertise and/or Research

Biomaterials, Nanotechnology, Drug Delivery, Molecular Imaging, Magnetic Resonance Imaging

Education

  • M.S. and Ph.D. in Biomedical Engineering, University of Texas at Austin

Contact

Phone:
  • 802-656-3382
Office Location:

Votey 309D

Courses Taught

  • BME 296A Nanobiomaterials
  • BME 181 Biomedical Engineering Laboratory II
  • BME 151 Fall BME Workshop