Assistant Professor

Doiron earned a M.S. and Ph.D. in biomedical engineering from the University of Texas at Austin and was the T. Chen Fong Postdoctoral Fellow in radiology and chemical engineering at the University of Calgary in Alberta, Canada. She was also the chief scientific officer at NanoPulse Biosciences, a startup company focused on biomedical applications of gold nanoparticles, for four years. Her research focuses on the development of nanoparticles for use in drug delivery and as contrast agents in magnetic resonance imaging in addition to studying toxicity mechanisms of nanoparticles. Applications of her work focus on detection and treatment of atherosclerosis, biofilm infections, cancer, and corneal keratitis.

Publications

   Nwasike, C., Purr, E., Yoo, E., Nagi, J.S., Doiron, A.L. (2021). Activatable Nanoparticles: Recent Advances in Redox-Sensitive Magnetic Resonance Contrast Agent Candidates Capable of Detecting Inflammation. Invited paper, Pharmaceutics 14(1):69. doi: 10.3390/ph14010069

   Nagi, J.S., Skorenko, K., Bernier, W.E., Jones, W.E., Doiron, A.L. (2020). Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy. Materials 13(1). doi: 10.3390/ma13010017

  Han, C., Goodwine, J., Romero, N., Sauer, K., Doiron, A.L. (2019). Enzyme-encapsulating polymeric nanoparticles: a potential adjunctive therapy in Pseudomonas aeruginosa biofilm-associated infection treatments. Colloids and Surfaces B 184:110512. doi:10.1016/j.colsurfb.2019.110512. *Cover Image

  Goodwine, J., Gil, J., Doiron, A., Valdes, J., Solis, M., Higa, A., Davis, S., Sauer, K. (2019). Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitro and in vivo. Scientific Reports, 9(1):3763. doi: 10.1038/s41598-019-40378-z

  Gomez-Garcia, J., Doiron, A.L., Steele R., Labouta, H.I., Vafadar, B., Shepherd R.D., Gates, I.D., Cramb, D.T., Childs S., Rinker K.D. (2018). Nanoparticle Localization in Blood vessels: Dependence on fluid shear stress, flow disturbances, and flow-induced changes in endothelial physiology. Nanoscale, 10, 15249-15261. doi: 10.1039/C8NR03440K

  Yoo, E., Liu, Y., Nwasike, C., Weith, A., Cordovez, B., Earhart, C., Doiron, A.L. (2018). Surface characterization of nanoparticles using near field light scattering. Beilstein Journal of Nanotechnology, 9, 1228–1238. doi: 10.3762/bjnano.9.114

  Liu, Y., Yoo, E., Han, C., Mahler, G., Doiron, A.L. (2018). Endothelial Barrier Dysfunction Induced by Nanoparticle Exposure Through Actin Remodeling via Caveolae/Raft-Regulated Calcium Signaling. NanoImpact 11:82-91. doi: 10.1016/j.impact.2018.02.007

  Liu, Y., Rogel, N., Harada, K., Jarret, L., Maiorana, C.H., German, G.K., Mahler, G., Doiron, A.L. (2017). Nanoparticle Size-Specific Actin Rearrangement and Barrier Dysfunction of Endothelial Cells. Nanotoxicology, 11(7):846-856. doi: 10.1080/17435390.2017.1371349; PMID: 28885066.

   Yoo, E., Cheng, H.A., Nardacci, L.E., Beaman, D., Lee, C., Fishbein, K.W., Spencer, R.G.S., Fisher, O.Z., Doiron, A.L. (2017). Activatable Interpolymer Complex-Superparamagnetic Iron Oxide Nanoparticles as Magnetic Resonance Contrast Agents Sensitive to Oxidative Stress. Colloids and Surfaces B: Biointerfaces, 158: 578-588. doi: 10.1016/j.colsurfb.2017.07.025; PMID: 28750340.

   Bromberg, L.A., Sanchez, S., Doiron, A., Lyles, M., German, G. (2017). Non-ionising UV light increases the optical density of hygroscopic self assembled DNA crystal films. Scientific Reports 7, Article number 6631. doi: 10.1038/s41598-017-06884-8; PMID: 28747733.

Areas of Expertise and/or Research

Biomaterials, Nanotechnology, Drug Delivery, Molecular Imaging, Magnetic Resonance Imaging

Education

  • M.S. and Ph.D. in Biomedical Engineering, University of Texas at Austin

Contact

Phone:
  • 802-656-3382
Office Location:

Votey 309D

Website(s):
  1. Lab Website

Courses Taught

  • BME 296 Medical Devices
  • BME 296 Biological Reaction to Materials
  • BME 250 Nanobiomaterials
  • BME 181 Biomedical Engineering Laboratory II
  • BME 151 Fall BME Workshop
  • BME 013 Design 1