The Laboratory for Clinical Biochemistry Research (LCBR) was founded in 1986 by Dr. Russell Tracy, Emeritus Distinguished Professor of Pathology and Laboratory Medicine.  Since that time the LCBR has served as a central biorepository and analysis laboratory for large NIH-funded longitudinal cohort studies, smaller clinical research studies, and individual research projects.  

Our freezer facility currently houses over 4 million blood, tissue and cryopreserved cell samples. Our analysis capabilities range from single protein analysis to multiplexed platforms, flow cytometry for cellular epidemiology, targeted proteomics, and specialized platforms for low abundance proteins, as well as DNA/RNA isolation, and extracellular vesicle isolation/characterization. 

Working closely with our Pathology partners in the Clinical Laboratories at the University of Vermont Medical Center we can offer CLIA certified assays that can be reported to study participants. Our lab follows Good Laboratory Practices (GLP) and has developed extensive quality systems to ensure the highest quality data, especially for longitudinal study data.  We are always investigating new assays and methodologies to further biomarker discovery, and we welcome inquiries for partnering in these efforts. 

Our research is dedicated to furthering our understanding of the molecular risk factors and pathways involved in the development and progression of a variety of diseases, such as cardiovascular disease, diabetes, lung disease, stroke, venous thromboembolism, dementia and other chronic diseases of aging, and is supported by a multidisciplinary team of dedicated faculty and staff.  We welcome the opportunity to work with research studies of any size and can assist with study development, sample handling, QA/QC, biorepository and analysis planning.

Margaret Doyle, Ph.D.

Associate Professor

Division Chief, Laboratory for Clinical Biochemistry Research