Research Overview

The Department of Pathology and Laboratory Medicine Research Program supports the common vision of The University of Vermont Medical Center and The UVM Robert Larner, M.D. College of Medicine: teaching, research and medical service are inseparable.

Our Research Mission Focus

Clinical and Basic Research

Pathology practice enhances our understanding of disease mechanisms. Clinical research aligns with faculty interests and collaborates with basic science programs. We partner with The University of Vermont Medical Center and UVM to support effective clinical and basic research.

Core Area Research Support

Core areas include Molecular Epidemiology and Histology Research Support. Given the competitive national science landscape and limited funding, focused collaboration is essential. We prioritize resources in these areas to maximize our programs' impact and ensure ongoing success.

Supporting New Investigators

Establishing a supportive environment for young investigators to develop into independent researchers or collaborative contributors, enhancing scientific literature and justifying additional resources.

REDOX: Biology and Pathology Program

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The Redox Biology and Pathology (RBP) Program is focused on investigating the role of reactive oxygen species (ROS) in normal and disease physiology, developing therapeutic strategies targeting redox dependent pathways in disease, and the development of tools to investigate redox dependent pathways. 

ROS, long categorized as damaging molecules, play a significant role in normal cell physiology while also supporting the development of numerous disease states. Investigators in the RBP use cell culture, animal models, and human tissue for investigating disease states including asthma, fibrosis, and cancer.

Our mission is to increase our understanding of redox-based mechanisms in the pathology of chronic disease, and to develop novel diagnostic tools to assess redox mechanisms in (patho)biology and new targeted redox-based therapeutic strategies.

Laboratory of Clinical Biochemistry Research

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The Laboratory for Clinical Biochemistry Research (LCBR) investigates risk factors for heart disease, stroke, venous thrombosis, obesity, diabetes, aging, and frailty. Utilizing diverse assays in population and family studies, LCBR focuses on coagulation, fibrinolysis, thrombosis, inflammation, and immune function, with findings connected to murine atherosclerosis research.

Clinical Studies: The laboratory research portfolio encompasses molecular and genetic epidemiology, family-based genetic studies, clinical trials, and basic research with murine disease models.

Technical Information: The LCBR Faculty and staff has accumulated a vast amount and diverse range of experience working with and developing multitudes of clinical assays, including information regarding Luminex Overview, and Luminex Data by Analyte.

Collaborations: The Laboratory staff have collaborated on numerous clinical studies, trials, and epidemiological research at local, national, and international levels.