Margaret Doyle
Associate Professor
Division Chief- Laboratory for Clinical Biochemistry Research
360 South Park Drive
UVM Colchester Research Facility
Room 235C
Colchester, VT 05446
United States
- Fellowship, Biochemistry, University of Vermont, Burlington, VT
- Ph.D., Biochemistry, Oklahoma State University, Stillwater, OK
- B.A., Chemistry, Mathematics, State University of New York at Potsdam, Potsdam NY
Department of Pathology and Laboratory Medicine
Areas of expertise
- Immune System in aging and disease
- Circulating biomarkers of disease
- Epidemiology of the immune system
BIO
As Co-Director of the Laboratory for Clinical Biochemistry Research (LCBR), our overall research goal is to personalize medicine by using clues found in a person's blood to understand and treat disease. To achieve this, we serve as a central biorepository and core assay laboratory for large, NIH-funded longitudinal cohort studies and clinical trials. Our highly collaborative work involves implementation of existing biomarker assays and development of novel assays with embedded quality measures to ensure assay stability over time, thus making them suitable for these longitudinal studies.
My research mainly involves examining the role of the immune system in age-related diseases, such as dementia and cardiovascular disease. What are the levels of the different immune cells in healthy people? Do these levels change with age? Do they change with onset of disease? Can they predict the onset of disease? What proteins are they making? Can we predict the proteins using transcriptomics of the cells? Are they affected by diet or the environment? Collaborating with multiple investigators and leveraging the large sample biorepository here at UVM, we hope to answer some of these questions.
Publications
Bio
As Co-Director of the Laboratory for Clinical Biochemistry Research (LCBR), our overall research goal is to personalize medicine by using clues found in a person's blood to understand and treat disease. To achieve this, we serve as a central biorepository and core assay laboratory for large, NIH-funded longitudinal cohort studies and clinical trials. Our highly collaborative work involves implementation of existing biomarker assays and development of novel assays with embedded quality measures to ensure assay stability over time, thus making them suitable for these longitudinal studies.
My research mainly involves examining the role of the immune system in age-related diseases, such as dementia and cardiovascular disease. What are the levels of the different immune cells in healthy people? Do these levels change with age? Do they change with onset of disease? Can they predict the onset of disease? What proteins are they making? Can we predict the proteins using transcriptomics of the cells? Are they affected by diet or the environment? Collaborating with multiple investigators and leveraging the large sample biorepository here at UVM, we hope to answer some of these questions.