- Ph.D., Biochemistry, University of Western Ontario
- B.S., Chemistry/Biochemistry, University of Western Ontario
Department of Biochemistry
Areas of expertise
Research Areas: Bone formation, stem cell biology, epigenetics, chromatin remodeling, gene regulation, osteoblast differentiation, mesenchymal stem cells, osteoporosis, cancer, cancer metastasis to bone, noncoding RNA, microRNA, genomics, bioinformatics techniques & methods ChIP-Seq, chromatin capture-based Seq, genome-wide profiling, cell culture, molecular biology, biochemistry, gene expression analysis
Job Duties: University teaching, course lecturing, graduate student mentoring, grant writing, NIH-funded research, principal investigator, faculty committee service, curriculum development disease relevance osteoporosis, osteoarthritis, age-related bone loss, breast cancer, bone metastasis, leukemia, osteosarcoma.
BIO
Jonathan Gordon is an Assistant Professor in the Department of Biochemistry at the Larner College of Medicine at the University of Vermont. His research career has focused on the epigenetic mechanisms governing normal mesenchymal stromal cell (MSC) commitment to the osteogenic lineage and recruitment of specialized MSCs in cancers and cancer progression. His research has a specific emphasis on transcriptional regulation, chromatin remodeling, and RNA-mediated gene regulation. This research carries direct implications for therapeutic strategies targeting osteoporosis, osteoarthritis, age-related bone loss, acute bone trauma and cancer.
Courses
- Guest Lecture, UVM BIOC6072A
- Cancer Biology Lecturer UVM BIOC3074
- Advanced Biochemistry of Human Disease
Publications
Awards and Achievements
- Ontario Graduate Scholarship in Science and Technology (OGSST)
- 2001–2005 Young Investigator Award, International Conference on Chemistry and Biology of Mineralized Tissues (ICCBMT)
- 2010 Member, American Society for Bone and Mineral Research (ASBMR) Member
- International Bone and Mineral Society Member
- Canadian Society of Biochemistry
- Molecular & Cellular Biology (CSBMCB)
Bio
Jonathan Gordon is an Assistant Professor in the Department of Biochemistry at the Larner College of Medicine at the University of Vermont. His research career has focused on the epigenetic mechanisms governing normal mesenchymal stromal cell (MSC) commitment to the osteogenic lineage and recruitment of specialized MSCs in cancers and cancer progression. His research has a specific emphasis on transcriptional regulation, chromatin remodeling, and RNA-mediated gene regulation. This research carries direct implications for therapeutic strategies targeting osteoporosis, osteoarthritis, age-related bone loss, acute bone trauma and cancer.
Courses
- Guest Lecture, UVM BIOC6072A
- Cancer Biology Lecturer UVM BIOC3074
- Advanced Biochemistry of Human Disease
Publications
Awards and Achievements
- Ontario Graduate Scholarship in Science and Technology (OGSST)
- 2001–2005 Young Investigator Award, International Conference on Chemistry and Biology of Mineralized Tissues (ICCBMT)
- 2010 Member, American Society for Bone and Mineral Research (ASBMR) Member
- International Bone and Mineral Society Member
- Canadian Society of Biochemistry
- Molecular & Cellular Biology (CSBMCB)
Select Publications
- Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro JAR Gordon, CE Tye, AV Sampaio, TM Underhill, GK Hunter, et al. Bone 41 (3), 462-473, 2007 A network connecting Runx2, SATB2, and the miR-23a∼ 27a∼ 24-2 cluster regulates the osteoblast differentiation program
- MQ Hassan, JAR Gordon, MM Beloti, CM Croce, AJ Wijnen, JL Stein, et al. Proceedings of the National Academy of Sciences 107 (46), 19879-19884, 2010 miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells
- MQ Hassan, Y Maeda, H Taipaleenmaki, W Zhang, M Jafferji, ... Journal of Biological Chemistry 287 (50), 42084-42092, 2012 Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis
- H Wu, TW Whitfield, JAR Gordon, JR Dobson, PWL Tai, AJ Van Wijnen, et al. Genome biology 15 (3), R52, 2014 Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease
- JAR Gordon, JL Stein, JJ Westendorf, AJ Van Wijnen Bone 81, 739-745, 2015