Dr. Dimitry Krementsov joined the BHSC department in 2017. He currently teaches several graduate and undergraduate courses in the MLS curriculum, and runs an extramurally funded research laboratory that engages undergraduate and graduate students from various programs.
Assistant Professor, Medical Laboratory Science
Research and/or Creative Works
Research in the Krementsov Laboratory is focused on understanding the molecular mechanisms underlying the pathogenesis of immune-mediated or infectious diseases. A major interest is the autoimmune disease multiple sclerosis, the most common neurologic disorder affecting young adults, which occurs when the immune system attacks the central nervous system. Other interests include host-microbe interactions and environmental influences.
For more information, please visit the Krementsov Lab webpage.
Selected Recent Publications
- Montgomery TL, Paavola M, Bruce EA, Botten JW, Crothers JW, Krementsov DN. Laboratory worker self-contamination with non-infectious SARS-CoV-2 DNA can result in false positive RT-PCR-based surveillance testing. J Clin Microbiol. 2021 Jun 18;59(7):e0072321. doi: 10.1128/JCM.00723-21.
- Blais LL, Montgomery TL, Amiel E, Deming PB, Krementsov DN. Probiotic and commensal gut microbial therapies in multiple sclerosis and its animal models: a comprehensive review. Gut Microbes. 2021 Jan-Dec;13(1):1943289. doi: 10.1080/19490976.2021.1943289.
- Montgomery T, Künstner A, Kennedy JJ, Fang Q, Asarian L, Culp-Hill R, D’Alessandro A, Teuscher C, Busch H, Krementsov DN. Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity. Proc Natl Acad Sci U S A. 2020 Oct 19;202002817. doi: 10.1073/pnas.2002817117.
- Lahue KG, Lara MK, Linton AA, Lavoie B, Fang Q, McGill MM, Crothers JW, Teuscher C, Mawe GM, Tyler AL, Mahoney JM, Krementsov DN. Identification of novel loci controlling inflammatory bowel disease susceptibility utilizing the genetic diversity of wild-derived mice. Genes and Immunity. (2020). https://doi.org/10.1038/s41435-020-00110-8.
- McGill MM, Sabikunnahar B, Fang Q, Teuscher C, Krementsov DN. The sex-specific role of p38 MAP kinase in CNS autoimmunity is regulated by estrogen receptor alpha. J Neuroimmunol. 2020 Mar 4;342:577209. doi: 10.1016/j.jneuroim.2020.577209.
- Krementsov DN, Asarian L, Fang Q, McGill MM, Teuscher C. Sex-Specific Gene-by-Vitamin D Interactions Regulate Susceptibility to Central Nervous System Autoimmunity. Front Immunol. 2018 Jul 17;9:1622. doi:10.3389/fimmu.2018.01622.
- Raza A, Crothers JW, McGill MM, Mawe GM, Teuscher C, Krementsov DN. Anti-inflammatory roles of p38α MAPK in macrophages are context dependent and require IL-10. J Leukoc Biol. 2017 Nov;102(5):1219-1227.
- Krementsov DN, Case LK, Dienz O, Raza A, Fang Q, Ather JL, Poynter ME, Boyson JE, Bunn JY, Teuscher C. Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection. Proc Natl Acad Sci U S A. 2017 Feb 27. pii: 201620889. PMID: 28242695
- Bearoff F, del Rio R, Case LK, Dragon JA, Nguyen-Vu T, Lin CY, Blankenhorn EP, Teuscher C, Krementsov DN. Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity. Genes and Immunity 2016 Dec;17(7):386-395. doi:10.1038/gene.2016.37. PMID: 27653816
Areas of Expertise and/or Research
Immunology, microbiology, genetics, microbiome, autoimmune disease, virology
- Postdoctoral training; University of Vermont (Laboratory of Dr. Cory Teuscher, Department of Medicine, Immunobiology Division, University of Vermont)
- Ph.D., Cell and Molecular Biology; University of Vermont (Laboratory of Dr. Markus Thali, Department of Microbiology and Molecular Genetics)
- B.S., Biology; University of Vermont (Undergraduate Research with Dr. Kathleen Trybus, Department of Molecular Physiology and Biophysics)
312C Rowell (Lab: 318 Rowell)
- BHSC 034 - Human Cell Biology
- MLS 255 - Clinical Microbiology II
- MLS 310 - Advanced Immunobiology
- BHSC 281 - Applied Molecular Biology