Research in the Krementsov laboratory is focused on understanding the molecular mechanisms underlying the pathogenesis of immune-mediated or infectious diseases. One of our principal interests is the autoimmune disease multiple sclerosis (MS), the most common neurologic disorder affecting young adults, which occurs occurs when the immune system aberrantly initiates an attack against the central nervous system. MS is three times more prevalent in women, and our research is aimed at understanding why and how the disease affects women and men differently. This line of investigation has uncovered a druggable molecular pathway in myeloid cells (macrophages or microglia), which is regulated by sex hormones.
Additionally, we are studying the genetic basis of MS, and how these genes may interact with various environmental risk factors such as vitamin D deficiency, or imbalance in the gut microbiome. The latter is of particular interest, and we are investigating the complex dialogue between the genome of the mammalian host and the commensal bacteria residing in the gut.
Other interests in the lab include genetics of other immune-mediated diseases such as inflammatory bowel disease, as well as genetics of host-pathogen interactions, especially viruses. We employ various immunologic and molecular techniques, animal and cellular models, as well as genomic approaches, including transcriptomics, bioinformatic analysis, forward genetics, 16S sequencing, etc.