Research in the Krementsov laboratory is focused on understanding the molecular mechanisms underlying the pathogenesis of immune-mediated or infectious diseases. One of our principal interests is the autoimmune disease multiple sclerosis (MS), the most common neurologic disorder affecting young adults, which occurs when the immune system aberrantly initiates an attack against the central nervous system.
The etiology of chronic autoimmune diseases, such as MS, is complex and multifactorial, dictated by genetic and environmental risk factors. The mechanisms and interplay of these risk factors are difficult to determine in human studies. Research in the Krementsov lab applies unique mouse genetics approaches to assess the role of genetics and environment in MS and other immune-mediated diseases. With regard to environment, a major current focus is unraveling the complex interactions between host genetics and the gut microbiome, as a novel putative risk factor for many chronic diseases.
MS is three times more prevalent in women, and our research is also aimed at understanding why and how the disease affects women and men differently. This line of investigation has uncovered a druggable molecular pathway in myeloid cells (macrophages or microglia), which is regulated by estrogen.
Other interests in the lab include genetics of other immune-mediated diseases such as inflammatory bowel disease, as well as genetics of host-pathogen interactions, especially viruses. We employ various immunologic and molecular techniques, animal and cellular models, as well as genomic approaches.