Assistant Professor, Medical Laboratory Science

Research in the Krementsov laboratory is focused on understanding the molecular mechanisms underlying the pathogenesis of immune-mediated or infectious diseases. One of our principal interests is the autoimmune disease multiple sclerosis (MS), the most common neurologic disorder affecting young adults, which occurs when the immune system aberrantly initiates an attack against the central nervous system.

The etiology of chronic autoimmune diseases, such as MS, is complex and multifactorial, dictated by genetic and environmental risk factors. The mechanisms and interplay of these risk factors are difficult to determine in human studies. Research in the Krementsov lab applies unique mouse genetics approaches to assess the role of genetics and environment in MS and other immune-mediated diseases. With regard to environment, a major current focus is unraveling the complex interactions between host genetics and the gut microbiome, as a novel putative risk factor for many chronic diseases.

MS is three times more prevalent in women, and our research is also aimed at understanding why and how the disease affects women and men differently. This line of investigation has uncovered a druggable molecular pathway in myeloid cells (macrophages or microglia), which is regulated by estrogen.

Other interests in the lab include genetics of other immune-mediated diseases such as inflammatory bowel disease, as well as genetics of host-pathogen interactions, especially viruses. We employ various immunologic and molecular techniques, animal and cellular models, as well as genomic approaches.

Publications

  • Krementsov DN, Asarian L, Fang Q, McGill MM, Teuscher C. Sex-Specific Gene-by-Vitamin D Interactions Regulate Susceptibility to Central Nervous System Autoimmunity. Front Immunol. 2018 Jul 17;9:1622. doi:10.3389/fimmu.2018.01622. PMID: 30065723
  • Raza A, Crothers JW, McGill MM, Mawe GM, Teuscher C, Krementsov DN. Anti-inflammatory roles of p38α MAPK in macrophages are context dependent and require IL-10. J Leukoc Biol. 2017 Nov;102(5):1219-1227.
  • Krementsov DN, Case LK, Dienz O, Raza A, Fang Q, Ather JL, Poynter ME, Boyson JE, Bunn JY, Teuscher C. Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection. Proc Natl Acad Sci U S A. 2017 Feb 27. pii: 201620889. PMID: 28242695
  • Bearoff F, del Rio R, Case LK, Dragon JA, Nguyen-Vu T, Lin CY, Blankenhorn EP, Teuscher C, Krementsov DN. Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity. Genes and Immunity 2016 Dec;17(7):386-395. doi:10.1038/gene.2016.37. PMID: 27653816
  • Krementsov DN, Case LK, Hickey WF, Teuscher C. Exacerbation of autoimmune neuroinflammation by dietary sodium is genetically controlled and sex specific. FASEB J. 2015 Aug;29(8):3446-57. PubMed PMID: 25917331
  • Krementsov DN, Noubade R, Dragon JA, Otsu K, Rincon M, Teuscher C. Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells. Ann Neurol. 2014 Jan;75(1):50-66. PubMed PMID: 24027119

Full Bibliography >>

Dimitry Krementsov

Areas of Expertise and/or Research

Autoimmunity, microbiome, neuroimmunology, sex differences, multiple sclerosis, gene-by-environment interactions, virology, inflammatory bowel disease

Education

  • Postdoctoral training; University of Vermont (Laboratory of Dr. Cory Teuscher, Department of Medicine, Immunobiology Division, University of Vermont)
  • Ph.D., Cell and Molecular Biology; University of Vermont (Laboratory of Dr. Markus Thali, Department of Microbiology and Molecular Genetics)
  • B.S., Biology; University of Vermont (Undergraduate Research with Dr. Kathleen Trybus, Department of Molecular Physiology and Biophysics)

Contact

Phone:
  • 802-656-9024
Office Location:

312C Rowell (Lab: 318 Rowell)