- PhD., Virology, University of Cambridge
- M.Phil., Virology, University of Cambridge
- BA., Biochemistry, with Honors in Biochemistry and General Honors, Vassar College
- Postdoctoral Fellow, University of Pennsylvania
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Areas of expertise
viruses, influenza, SARS-CoV-2, COVID-19, HPAI, Rab11, vesicular transport.
BIO
Emily Bruce is an Assistant Professor at the Larner College of Medicine. Her work focuses on using molecular and cellular biology to understand how the cellular Rab 11 recycling pathway functions in healthy cells, and how that differs in cells infected with influenza. Emily's research focuses on how the process of genome transport influences influenza viral assembly and reassortment, as well as how regulation of encapsidation affects nucleocapsid function for SARS-CoV-2. Emily teaches virology to undergraduate, graduate and medical students, including Eukaryotic Virology.
Courses
- Eukaryotic Virology
Awards and Achievements
Gates Cambridge Scholar (2007-2012)
Bio
Emily Bruce is an Assistant Professor at the Larner College of Medicine. Her work focuses on using molecular and cellular biology to understand how the cellular Rab 11 recycling pathway functions in healthy cells, and how that differs in cells infected with influenza. Emily's research focuses on how the process of genome transport influences influenza viral assembly and reassortment, as well as how regulation of encapsidation affects nucleocapsid function for SARS-CoV-2. Emily teaches virology to undergraduate, graduate and medical students, including Eukaryotic Virology.
Courses
- Eukaryotic Virology
Awards and Achievements
Gates Cambridge Scholar (2007-2012)
Select Publications
Select Publications
- Kubinski HC, Despres HW, Johnson BA, Schmidt MM, Jaffrani SA, Turner AH, Fanuele CD, Mills MG, Lokugamage KG, Dumas CM, Shirley DJ, Estes LK, Pekosz A, Crothers JW, Roychoudhury P, Greninger AL, Jerome KR, Di Genova BM, Walker DH, Ballif BA, Ladinsky MS, Bjorkman PJ, Menachery VD, Bruce EA. Variant mutation G215C in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation. PLoS Biol. 2025 Apr;23(4):e3003115.
- PubMed Central PMCID: PMC12040272. Despres HW, Mills MG, Shirley DJ, Schmidt MM, Huang ML, Roychoudhury P, Jerome KR, Greninger AL, Bruce EA. Measuring infectious SARS-CoV-2 in clinical samples reveals a higher viral titer:RNA ratio for Delta and Epsilon vs. Alpha variants. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5)
- PubMed Central PMCID: PMC8812544. Banerjee AK*, Blanco MR*, Bruce EA*, Honson DD, Chen LM, Chow A, Bhat P, Ollikainen N, Quinodoz SA, Loney C, Thai J, Miller ZD, Lin AE, Schmidt MM, Stewart DG, Goldfarb D, De Lorenzo G, Rihn SJ, Voorhees RM, Botten JW, Majumdar D, Guttman M. SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses. Cell. 2020 Nov 25;183(5):1325-1339.e21.
- PubMed Central PMCID: PMC7543886. Bruce EA*, Huang ML*, Perchetti GA, Tighe S, Laaguiby P, Hoffman JJ, Gerrard DL, Nalla AK, Wei Y, Greninger AL, Diehl SA, Shirley DJ, Leonard DGB, Huston CD, Kirkpatrick BD, Dragon JA, Crothers JW, Jerome KR, Botten JW. Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step. PLoS Biol. 2020 Oct;18(10):e3000896.
- PubMed Central PMCID: PMC7556528. Bruce EA, Digard P, Stuart AD. The Rab11 pathway is required for influenza A virus budding and filament formation. J Virol. 2010 Jun;84(12):5848-59. PubMed Central PMCID: PMC2876627.
Sara Jaffrani - Laboratory technician, sara.jaffrani@uvm.edu
Conor Fanuele - MMG Undergraduate Researcher
Matthew Owens - PhD Graduate Student, CMB program
Deborah Ajayi - PhD Graduate Student, CMB program