Peter Calabresi
Chair, Department of Neurological Sciences
Professor, Neurological Sciences
PRONUNCIATION kaa·laab·reh·see
PRONOUNS he/him
- M.D. Brown University School of Medicine, Providence, RI
- B.S., Biology, Yale University, New Haven, CT
- Residency, Internal Medicine and Neurology, University of Rochester, Rochester, NY
- Fellowship, Neuroimmunology, NINDS, National Institute of Health, Bethesda, MD
Department of Neurological Sciences
Areas of expertise
Neuroimmunology, neurodegeneration, glia, multiple sclerosis, retinal pathology.
BIO
Peter A. Calabresi, MD is Professor and Chair of the Department of Neurological Sciences at the Larner College of Medicine, University of Vermont. He earned his undergraduate degree from Yale College and medical degree from Brown University. Dr. Calabresi did his medicine and neurology residency training at Strong Memorial Hospital in Rochester, NY, and completed a research fellowship at the National Institutes of Health, Neuroimmunology Branch. Dr. Calabresi has served on the Editorial Boards of the Journal of Clinical Investigation, Neurology, and the Multiple Sclerosis Journal. He served as Chair of a grant review committee of the National Multiple Sclerosis Society and was a standing member of the NIH Clinical Neuroimmunology and Brain Tumors Study Section. Dr. Calabresi worked at Johns Hopkins for 22 years where he was the co-director of the Johns Hopkins Precision Medicine MS Center of Excellence and Director of the Division of Neuroimmunology and Neurological Infections. Dr. Calabresi has been the principal investigator on several clinical trials and oversees numerous translational laboratory research projects. His specific laboratory research interest lies in understanding how effector memory T cells activate glial cells in the brain to cause tissue damage, and how to modulate this process for neuroprotection and remyelination. Dr. Calabresi has published over 500 research papers including numerous articles on imaging and the immunopathogenesis of MS. He was the recipient of a five-year NMSS Collaborative Center grant from the National MS Society to study endogenous remyelination in MS, and the Jacob Javits Neuroscience Investigator award from the National Institutes of Health. Dr. Calabresi was co-awarded the Barancik prize for innovation in MS research (2015) and was elected to the American Association of Physicians (2017) and the National Academy of Medicine (2025).
Publications
Awards and Achievements
- Steven C. Reingold Research Award
- National MS Society Alpha Omega Alpha Honor Medical Society
- Member Osler Attending Preceptor at Johns Hopkins Hospital
- Jacob Javits Neuroscience Investigator Award
- National Institutes of Health Barancik Award for Innovation in MS Research Fellow
- American Association of Physicians Raymond D. Adams Lectureship Award from the American Neurological Association Consortium of MS Centers
- Giant in MS Research Award Snyder-Granader Professor in Multiple Sclerosis Member
- National Academy of Medicine
Bio
Peter A. Calabresi, MD is Professor and Chair of the Department of Neurological Sciences at the Larner College of Medicine, University of Vermont. He earned his undergraduate degree from Yale College and medical degree from Brown University. Dr. Calabresi did his medicine and neurology residency training at Strong Memorial Hospital in Rochester, NY, and completed a research fellowship at the National Institutes of Health, Neuroimmunology Branch. Dr. Calabresi has served on the Editorial Boards of the Journal of Clinical Investigation, Neurology, and the Multiple Sclerosis Journal. He served as Chair of a grant review committee of the National Multiple Sclerosis Society and was a standing member of the NIH Clinical Neuroimmunology and Brain Tumors Study Section. Dr. Calabresi worked at Johns Hopkins for 22 years where he was the co-director of the Johns Hopkins Precision Medicine MS Center of Excellence and Director of the Division of Neuroimmunology and Neurological Infections. Dr. Calabresi has been the principal investigator on several clinical trials and oversees numerous translational laboratory research projects. His specific laboratory research interest lies in understanding how effector memory T cells activate glial cells in the brain to cause tissue damage, and how to modulate this process for neuroprotection and remyelination. Dr. Calabresi has published over 500 research papers including numerous articles on imaging and the immunopathogenesis of MS. He was the recipient of a five-year NMSS Collaborative Center grant from the National MS Society to study endogenous remyelination in MS, and the Jacob Javits Neuroscience Investigator award from the National Institutes of Health. Dr. Calabresi was co-awarded the Barancik prize for innovation in MS research (2015) and was elected to the American Association of Physicians (2017) and the National Academy of Medicine (2025).
Publications
Awards and Achievements
- Steven C. Reingold Research Award
- National MS Society Alpha Omega Alpha Honor Medical Society
- Member Osler Attending Preceptor at Johns Hopkins Hospital
- Jacob Javits Neuroscience Investigator Award
- National Institutes of Health Barancik Award for Innovation in MS Research Fellow
- American Association of Physicians Raymond D. Adams Lectureship Award from the American Neurological Association Consortium of MS Centers
- Giant in MS Research Award Snyder-Granader Professor in Multiple Sclerosis Member
- National Academy of Medicine
Select Publications
- Mace JW, Gadani SP, Smith MD, Galleguillos D, Kang BG, Roy M, Liu M, Summers B, Garton T, Gharagozloo M, Gill AJ, Pardo CA, Sotirchos ES, Dawson VL, Dawson TM, Calabresi PA. Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos. Nat Neurosci. 2026 Feb 17; PubMed PMID: 41703302.
- Garton T, Smith MD, Kesharwani A, Gharagozloo M, Oh S, Na CH, Absinta M, Reich DS, Zack DJ, Calabresi PA. Myeloid lineage C3 induces reactive gliosis and neuronal stress during CNS inflammation. Nat Commun. 2025 Apr 12;16(1):3481. PubMed Central PMCID: PMC11992029.
- Absinta M, Maric D, Gharagozloo M, Garton T, Smith MD, Jin J, Fitzgerald KC, Song A, Liu P, Lin JP, Wu T, Johnson KR, McGavern DB, Schafer DP, Calabresi PA, Reich DS. A lymphocytemicroglia- astrocyte axis in chronic active multiple sclerosis. Nature. 2021 Sep;597(7878):709-714. PubMed Central PMCID: PMC8719282.
- Kirby L, Jin J, Cardona JG, Smith MD, Martin KA, Wang J, Strasburger H, Herbst L, Alexis M, Karnell J, Davidson T, Dutta R, Goverman J, Bergles D, Calabresi PA. Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination. Nat Commun. 2019 Aug 29;10(1):3887. PubMed Central PMCID: PMC6715717.
- Reich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. N Engl J Med. 2018 Jan 11;378(2):169-180. PubMed Central PMCID: PMC6942519.