Michael Toth
Professor of Medicine
Vice Chair for Research
Co-Director, Office of Research and Engagement
PRONUNCIATION T-oe-th (uses long ‘o’)
- Ph.D., Physiology, University of Maryland at Baltimore
- B.S., Biological Sciences, University of Vermont
- Fellowship, University of Vermont
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Areas of expertise
skeletal muscle, metabolism, exercise, physical disability, geriatrics.
BIO
Michael Toth is a Professor and Vice Chair for Research in the Department of Medicine. His research focuses on skeletal muscle biology in the context of physical disability with aging and disease and interventions to prevent or correct impaired physical function. He has focused primarily on translational studies in a variety of older adult populations with acute or chronic disease, such as heart failure, cancer, and knee osteoarthritis. More recently, his laboratory has taken the knowledge gained from these studies to develop and evaluate point-of-care interventions that may mitigate skeletal muscle maladaptations that contribute to age-related physical disability.
Publications
Awards and Achievements
- 1993 Student Investigator of the Year: New England Chapter of the American College of Sports Medicine
- 1994 Graduate Merit Award: University of Maryland at Baltimore
- 1995 American Federation for Aging Research Glenn Foundation Scholarship for Research in the Biology of Aging
- 2003 New Investigator Award from the Endocrinology and Metabolism Section of the American Physiological Society
- 2014 Silver Stethoscope Teaching Award, UVM College of Medicine
Bio
Michael Toth is a Professor and Vice Chair for Research in the Department of Medicine. His research focuses on skeletal muscle biology in the context of physical disability with aging and disease and interventions to prevent or correct impaired physical function. He has focused primarily on translational studies in a variety of older adult populations with acute or chronic disease, such as heart failure, cancer, and knee osteoarthritis. More recently, his laboratory has taken the knowledge gained from these studies to develop and evaluate point-of-care interventions that may mitigate skeletal muscle maladaptations that contribute to age-related physical disability.
Publications
Awards and Achievements
- 1993 Student Investigator of the Year: New England Chapter of the American College of Sports Medicine
- 1994 Graduate Merit Award: University of Maryland at Baltimore
- 1995 American Federation for Aging Research Glenn Foundation Scholarship for Research in the Biology of Aging
- 2003 New Investigator Award from the Endocrinology and Metabolism Section of the American Physiological Society
- 2014 Silver Stethoscope Teaching Award, UVM College of Medicine
Select Publications
- Snoke DB, van der Velden JL, Bellafleur ER, Dearborn JS, Lenahan SM, Beal AE, Aboushousha R, Heininger SCJ, Ather JL, Mank MM, Sarausky H, Stephenson D, Reisz JA, D'Alessandro A, Majumdar D, Ahern TP, Xu K, Sandler KL, Landman BA, Janssen-Heininger YMW, Poynter ME, Seward DJ, Toth MJ. Early adipose tissue wasting in a preclinical model of human lung cancer cachexia. Cell Rep. 2025 Sep 23;44(9):116278. PMCID: PMC12505381.
- Miller MS, Vanburen P, Lewinter MM, Lecker SH, Selby DE, Palmer BM, Maughan DW, Ades PA, Toth MJ. Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function. Circ Heart Fail. 2009 Nov;2(6):700-6. PMCID: PMC2782533.
- Guigni BA, Fix DK, Bivona JJ 3rd, Palmer BM, Carson JA, Toth MJ. Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubes. Am J Physiol Cell Physiol. 2019 Dec 1;317(6):C1213-C1228. PMCID: PMC6957384.
- Miller MS, Bedrin NG, Callahan DM, Previs MJ, Jennings ME 2nd, Ades PA, Maughan DW, Palmer BM, Toth MJ. Age-related slowing of myosin actin cross-bridge kinetics is sex specific and predicts decrements in whole skeletal muscle performance in humans. J Appl Physiol (1985). 2013 Oct 1;115(7):1004-14. PMCID: PMC3798822.
- Rengo JL, Savage PD, Hirashima F, Leavitt BJ, Ades PA, Toth MJ. Improvement in Physical Function After Coronary Artery Bypass Graft Surgery Using a Novel Rehabilitation Intervention: A RANDOMIZED CONTROLLED TRIAL. J Cardiopulm Rehabil Prev. 2021 Nov 1;41(6):413-418. PMCID: PMC8310525.