Larner College of Medicine

Kenneth Hallows

Professor, Department of Medicine

Network Division Chief, Nephrology

person smiling
Alma mater(s)
  • M.D., University of Rochester
  • Ph.D., Biophysics, University of Rochester
  • Sc.B, Biophysics with Honors, Brown University
Affiliated Department(s)

Department of Medicine, Division of Nephrology

Areas of expertise

Polycystic kidney disease, cystic fibrosis, acute kidney injury, AMP-activated protein kinase, epithelial sodium channel, cystic fibrosis transmembrane conductance regulator, vacuolar proton-lranslocating ATPases, water-electrolyte balance, energy metabolism, phosphorylation.

BIO

Dr. Hallows is an academic nephrologist and physician-scientist with clinical interests and expertise in the management of polycystic kidney disease, fluid and electrolyte disorders and acute kidney injury. He believes in a collaborative relationship with his patients — working together to improve health and overall quality of life. He encourages patients to become educated, take an active role in their own care and participate in discussions regarding various treatment options based on current standards or care and the latest research findings. His passion as a health care provider is to care for kidney disease patients and conduct advanced research to develop new therapies that cure or improve outcomes and quality of life for those with acute and chronic kidney diseases. Specifically, his research is focused on polycystic kidney disease pathogenesis to identify new therapeutic targets, epithelial solute transport and its coupling to cellular metabolic changes and identifying new therapeutic targets for kidney diseases.

Publications

Publications (PubMed)

Awards and Achievements

  • 1999, 2000 J. Russell Elkinton Renal Fellow Teaching Award (University of Pennsylvania) 
  • 2025 Robert F. & Genevieve B. Patrick Endowed Chair in Nephrology 
  • 2024 NEMO Prize “RNA-Based Nanoparticle Therapy for Polycystic Kidney Disease” (University of Southern California) 
  • 2022 Awarded 2021 Paper of the Year: “Metformin improves relevant 4 disease parameters in an autosomal dominant polycystic kidney disease mouse model.” (American Journal of Physiology-Renal Physiology) 
  • 2016 Named among Top Doctors in Nephrology (Pasadena Magazine) 
  • 2009 Lazaro J. Mandel Young Investigator Award (American Physiological Society) 
  • 2006 Carl W. Gottschalk Research Scholar Grantee (American Society of Nephrology) 
  • 2004 Inducted as Fellow of the American Society of Nephrology 
  • 2000 J. Russell Elkinton Renal Fellow Teaching Award (University of Pennsylvania) 
  • 1999 Franklin McDonald Postdoctoral Fellowship (declined – National Kidney Foundation) 
  • 1999 FIRST Postdoctoral Fellowship (declined – American Heart Association) 
  • 1999 Renal Fellow Research Forum Prize (National Kidney Foundation) 
  • 1995 Awarded Doctor of Medicine with Honor (University of Rochester) 
  • 1994 Alpha Omega Alpha National Medical Society 
  • 1992 William F. Neuman Award in Biophysics (University of Rochester) 
  • 1988 Walle J.H. Nauta Award in Neural Sciences (University of Rochester) 
  • 1988 Edward D. Adolph Prize in Physiology (University of Rochester) 
  • 1987-1991, 1993-95 Medical Scientist Training Program Fellowship (N.I.H. at University of Rochester) 
  • 1987 Susan Colver Rosenberger Prize in Biology (Brown University) 
  • 1987 Honors in Biophysics (Brown University) 
  • 1987 Magna Cum Laude (Brown University) 
  • 1983-1987 CBS Merit Scholarship (Brown University)

    Academic Appointments

  • 2025- present, University of Vermont, Professor (with Tenure), Medicine
  • 2015-2025, University of Southern California Keck School of Medicine, Professor (with Tenure), Medicine
  • 2014-2015, University of Pittsburgh School of Medicine, Faculty Member, Center for Critical Care Nephrology
  • 2011-2015       University of Pittsburgh, Associate Professor of Medicine (with Tenure), Medicine
  • 2011-2015, University of Pittsburgh, Associate Professor, Cell Biology
  • 2002-2010, University of Pittsburgh, Assistant Professor, Medicine
  • 2002-2010, University of Pittsburgh, Assistant Professor, Cell Biology and Physiology
  • 2002-2015, University of Pittsburgh, Graduate Program Faculty, Cell Biology and Molecular Physiology
  • 2001-2002, University of Pennsylvania, Instructor, Medicine

Bio

Dr. Hallows is an academic nephrologist and physician-scientist with clinical interests and expertise in the management of polycystic kidney disease, fluid and electrolyte disorders and acute kidney injury. He believes in a collaborative relationship with his patients — working together to improve health and overall quality of life. He encourages patients to become educated, take an active role in their own care and participate in discussions regarding various treatment options based on current standards or care and the latest research findings. His passion as a health care provider is to care for kidney disease patients and conduct advanced research to develop new therapies that cure or improve outcomes and quality of life for those with acute and chronic kidney diseases. Specifically, his research is focused on polycystic kidney disease pathogenesis to identify new therapeutic targets, epithelial solute transport and its coupling to cellular metabolic changes and identifying new therapeutic targets for kidney diseases.

Awards and Achievements

  • 1999, 2000 J. Russell Elkinton Renal Fellow Teaching Award (University of Pennsylvania) 
  • 2025 Robert F. & Genevieve B. Patrick Endowed Chair in Nephrology 
  • 2024 NEMO Prize “RNA-Based Nanoparticle Therapy for Polycystic Kidney Disease” (University of Southern California) 
  • 2022 Awarded 2021 Paper of the Year: “Metformin improves relevant 4 disease parameters in an autosomal dominant polycystic kidney disease mouse model.” (American Journal of Physiology-Renal Physiology) 
  • 2016 Named among Top Doctors in Nephrology (Pasadena Magazine) 
  • 2009 Lazaro J. Mandel Young Investigator Award (American Physiological Society) 
  • 2006 Carl W. Gottschalk Research Scholar Grantee (American Society of Nephrology) 
  • 2004 Inducted as Fellow of the American Society of Nephrology 
  • 2000 J. Russell Elkinton Renal Fellow Teaching Award (University of Pennsylvania) 
  • 1999 Franklin McDonald Postdoctoral Fellowship (declined – National Kidney Foundation) 
  • 1999 FIRST Postdoctoral Fellowship (declined – American Heart Association) 
  • 1999 Renal Fellow Research Forum Prize (National Kidney Foundation) 
  • 1995 Awarded Doctor of Medicine with Honor (University of Rochester) 
  • 1994 Alpha Omega Alpha National Medical Society 
  • 1992 William F. Neuman Award in Biophysics (University of Rochester) 
  • 1988 Walle J.H. Nauta Award in Neural Sciences (University of Rochester) 
  • 1988 Edward D. Adolph Prize in Physiology (University of Rochester) 
  • 1987-1991, 1993-95 Medical Scientist Training Program Fellowship (N.I.H. at University of Rochester) 
  • 1987 Susan Colver Rosenberger Prize in Biology (Brown University) 
  • 1987 Honors in Biophysics (Brown University) 
  • 1987 Magna Cum Laude (Brown University) 
  • 1983-1987 CBS Merit Scholarship (Brown University)

    Academic Appointments

  • 2025- present, University of Vermont, Professor (with Tenure), Medicine
  • 2015-2025, University of Southern California Keck School of Medicine, Professor (with Tenure), Medicine
  • 2014-2015, University of Pittsburgh School of Medicine, Faculty Member, Center for Critical Care Nephrology
  • 2011-2015       University of Pittsburgh, Associate Professor of Medicine (with Tenure), Medicine
  • 2011-2015, University of Pittsburgh, Associate Professor, Cell Biology
  • 2002-2010, University of Pittsburgh, Assistant Professor, Medicine
  • 2002-2010, University of Pittsburgh, Assistant Professor, Cell Biology and Physiology
  • 2002-2015, University of Pittsburgh, Graduate Program Faculty, Cell Biology and Molecular Physiology
  • 2001-2002, University of Pennsylvania, Instructor, Medicine

Select Publications

  • Jia, J., Bissa, B., Brecht, L., Allers, L., Choi, S.W., Gu, Y., Zbinden, M., Burge, M., Timmins, G., Hallows, K., Behrends, C., and Deretic, V. AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system. Autophagy. 2020 Aug; 16(8): 1550-1552. doi: 10.1080/15548627.2020.1788890. Epub 2020 Jul 25. PMID: 32597364. PMCID: PMC7469532.
  • Saitta, B., Jalili, M.F., Zohoorkari, H., Rao, R., Hallows, K.R., Baty, C.J., and Pastor- Soler, N.M. Ex vivo kidney slice preparations as a model system to study signaling cascades in kidney epithelial cells. Methods Cell Biol. 153: 185-203, 2019. Epub 2019 Jun 6. doi: 10.1016/bs.mcb.2019.04.017. PMID: 31395379.
  • Rajani, R.*, Pastor-Soler, N.M. and Hallows, K.R. Role of AMPK in kidney tubular transport, metabolism and disease. Curr. Opin. Nephrol. Hypertens. 26: 375-383, 2017. doi: 10.1097/MNH.0000000000000349. PMID: 28614117. *Trainee mentored by me
  • Singh, T.* and Hallows, K.R. Hemodialysis for the treatment of severe accidental hypothermia. Semin. Dial. 27: 295-297, 2014. Epub 2013 Oct 9. doi: 10.1111/sdi.12156. PMID: 24118090. *Trainee mentored by me 
  • Pastor-Soler, N.M. and Hallows, K.R. AMP-activated protein kinase regulation of kidney tubular transport. Curr. Opin. Nephrol. Hypertens. 21: 523-533, 2012. Epub 2012 Jul 19. doi: 10.1097/MNH.0b013e3283562390. PMID: 22801443.