Larner College of Medicine

Jean Celli

Professor, Microbiology and Molecular Genetics

person smiling
Alma mater(s)
  • PhD, Microbiology, Université Pierre & Marie Curie, Paris 6, France
  • BSc, Molecular Genetics, Université Paris 11, France
Affiliated Department(s)

Department of Microbiology and Molecular Genetics

Areas of expertise

Microbe-host interactions, microbial pathogenesis, macrophage, bacterial secretion systems, cell biology, membrane traffic, autophagy.

BIO

Jean Celli is a Professor of Microbiology in the Larner College of Medicine. His work centers on understanding the cellular and molecular mechanisms of intracellular survival and proliferation of zoonotic bacterial pathogens. Using Brucella abortus, the causative agent of the worldwide disease brucellosis, as model pathogen, Dr Celli's research focuses on understanding how bacteria remodel host transport and autophagic functions during infections, via delivery of effector proteins to promote bacterial survival, proliferation and egress. His teaching draws from this research, including courses on host-microbe interactions.

  • Received his Ph.D. in Microbiology, Université Pierre & Marie Curie, Paris 6, France (1997), studying genetic mobile elements that transfer antibiotic resistance among pathogenic bacteria.
  • Trained as a Postdoctoral Fellow at the University of British Columbia, Vancouver, Canada (1998-2001), focusing on how the food-borne pathogen Enteropathogenic Escherichia coli (EPEC) disarms immune phagocytes.
  • Held an INSERM CR2 Research Scientist position (2001-2004) at the Centre d’Immunologie de Marseille-Luminy, France, where his research focused on characterizing the intracellular cycle of the Brucellosis-causing bacterium Brucella abortus.
  • Held an NIH Investigator position at the NIH Rocky Mountain Laboratories, NIAID from 2004 to 2013, where he further developed cellular and molecular studies of bacterial pathogen interactions with phagocytes.
  • Became faculty at the Paul G. Allen School for Global Health at Washington State University as Associate Professor then Professor between 2013 and 2022 to continue research on the cell biology of zoonotic bacterial infections.
  • Joined UVM Department of Microbiology and Molecular Genetics in 2023 as Professor.

Courses

  • MMG6990A - Host-Microbe Interactions

Publications

NIH Publications

Bio

Jean Celli is a Professor of Microbiology in the Larner College of Medicine. His work centers on understanding the cellular and molecular mechanisms of intracellular survival and proliferation of zoonotic bacterial pathogens. Using Brucella abortus, the causative agent of the worldwide disease brucellosis, as model pathogen, Dr Celli's research focuses on understanding how bacteria remodel host transport and autophagic functions during infections, via delivery of effector proteins to promote bacterial survival, proliferation and egress. His teaching draws from this research, including courses on host-microbe interactions.

  • Received his Ph.D. in Microbiology, Université Pierre & Marie Curie, Paris 6, France (1997), studying genetic mobile elements that transfer antibiotic resistance among pathogenic bacteria.
  • Trained as a Postdoctoral Fellow at the University of British Columbia, Vancouver, Canada (1998-2001), focusing on how the food-borne pathogen Enteropathogenic Escherichia coli (EPEC) disarms immune phagocytes.
  • Held an INSERM CR2 Research Scientist position (2001-2004) at the Centre d’Immunologie de Marseille-Luminy, France, where his research focused on characterizing the intracellular cycle of the Brucellosis-causing bacterium Brucella abortus.
  • Held an NIH Investigator position at the NIH Rocky Mountain Laboratories, NIAID from 2004 to 2013, where he further developed cellular and molecular studies of bacterial pathogen interactions with phagocytes.
  • Became faculty at the Paul G. Allen School for Global Health at Washington State University as Associate Professor then Professor between 2013 and 2022 to continue research on the cell biology of zoonotic bacterial infections.
  • Joined UVM Department of Microbiology and Molecular Genetics in 2023 as Professor.

Courses

  • MMG6990A - Host-Microbe Interactions

Publications

Microscopic image
Confocal microscope image of a Brucella abortus-infected HeLa cell showing extensive intracellular bacterial replication (bacteria appear in red) and formation of egress vacuoles (green vesicles).”

Lab Team

Pedro Francisco Soler Llorens, PhD - Postdoctoral Fellow
Aiden Cox, Master's student
Gaia Hess, Research Technician
Maddie Guest, Undergraduate