Chris E. Holmes
Professor of Medicine, Hematology and Oncology
Director, Cancer Clinical Programs, UVM Cancer Center
Division Chief for Hematology and Oncology
- M.D., University of Virginia School of Medicine
- Ph.D., Chemistry, University of Virginia Graduate School of Arts and Sciences
- B.S., magna cum laude, Honors Scholar, Chemistry, James Madison University
- Internship, Internal Medicine, Robert Larner College of Medicine
- Residency, Internal Medicine, Robert Larner College of Medicine
- Fellowship, Hematology, University of Vermont Medical Center
Department of Medicine
Division of Hematology and Oncology
UVM Cancer Center
Areas of expertise
thrombosis, bleeding, cancer-associated thrombosis, platelets, clinical research, translational research.
BIO
Dr. Chris Holmes is Division Chief, Hematology and Oncology and Medical Director of Cancer Clinical Programs for UVM Health. In addition, she is the Medical Director of the Vermont Regional Hemophilia Treatment Center, a federally designated center that serves patients with bleeding disorders in the states of Vermont and Northern New York.
Dr. Holmes received her Ph.D.in Chemistry as well as her M.D. from the University of Virginia. She subsequently completed an Internal Medicine residency and fellowship in Hematology and Oncology at the University of Vermont.
Dr. Holmes’ research program is focused on developing evidence-based, clinical interventions to reduce venous thrombosis and bleeding complications and improve mortality in patients with cancer. Her work has led to numerous high-impact publications and has been supported by funding from multiple sources including the American Cancer Society, Department of Defense and, most recently an R21 grant from the National Institutes of Health. She has served as the PI on several clinical trials involving patients with hematologic conditions as well as cancer.
Dr. Holmes has clinical expertise in both benign and malignant hematology. She cares for patients with a wide spectrum of hematologic disorders including disorders of platelet function and number, thrombosis, hemostasis, myeoproliferative disease and hematologic malignancies.
Publications
Dr. Holmes' publications on Google Scholar
Awards and Achievements
- Member, Board of Directors, Cardiovascular Research Institute,
- University of Vermont, College of Medicine Fellow,
- American College of Physicians Executive Committee,
- New England Region 1, Hemophilia Treatment Centers Co-chair,
- Research Subcommittee, New England Region 1
- Hemophilia Treatment Centers Inventor Award,
- University of Vermont Quality Scholarship Award, Department of Medicine
Bio
Dr. Chris Holmes is Division Chief, Hematology and Oncology and Medical Director of Cancer Clinical Programs for UVM Health. In addition, she is the Medical Director of the Vermont Regional Hemophilia Treatment Center, a federally designated center that serves patients with bleeding disorders in the states of Vermont and Northern New York.
Dr. Holmes received her Ph.D.in Chemistry as well as her M.D. from the University of Virginia. She subsequently completed an Internal Medicine residency and fellowship in Hematology and Oncology at the University of Vermont.
Dr. Holmes’ research program is focused on developing evidence-based, clinical interventions to reduce venous thrombosis and bleeding complications and improve mortality in patients with cancer. Her work has led to numerous high-impact publications and has been supported by funding from multiple sources including the American Cancer Society, Department of Defense and, most recently an R21 grant from the National Institutes of Health. She has served as the PI on several clinical trials involving patients with hematologic conditions as well as cancer.
Dr. Holmes has clinical expertise in both benign and malignant hematology. She cares for patients with a wide spectrum of hematologic disorders including disorders of platelet function and number, thrombosis, hemostasis, myeoproliferative disease and hematologic malignancies.
Publications
Awards and Achievements
- Member, Board of Directors, Cardiovascular Research Institute,
- University of Vermont, College of Medicine Fellow,
- American College of Physicians Executive Committee,
- New England Region 1, Hemophilia Treatment Centers Co-chair,
- Research Subcommittee, New England Region 1
- Hemophilia Treatment Centers Inventor Award,
- University of Vermont Quality Scholarship Award, Department of Medicine
Select Publications
- Impact of Venous Thrombosis Prevention in Ambulatory Oncology: Importance of Guideline Adherence. JCO Oncol Pract 2026: https://doi.org/10.1200/OP-25-01211
- Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients with Cancer: A Randomized Clinical Trial JAMA. 2023;329(22):1924-1933. doi:10.1001/jama.2023.7843
- A Successful Model for Guideline Implementation to Prevent Cancer-Associated Thrombosis: Venous Thromboembolism Prevention in the Ambulatory Cancer Clinic JCO Oncol Pract 2020 April 8. doi: 10.1200/JOP.19.00697. PMID: 32267798
- Venous thromboembolism prevention program implementation in a community oncology practice: a cohort study. Lancet Reg Health Am 2024 38: 100866. DOI 10.1016/j.lana.2024.100866.
- The platelet contribution to cancer progression. J Thromb Haemostasis 2011; 9(2):237-249. PMID: 21040448.