- Ph.D., Biological Sciences, Jawaharlal Nehru University, New Delhi, India
- MSc., Biotechnology, University of Jammu, Jammu, India
- BSc., Chemistry, Botany, and Zoology, Magadh University, Bodhgaya, India
Department of Pathology and Laboratory Medicine
BIO
My research interests have focused on catching the mediators involved in various lung diseases like Pulmonary Fibrosis (PF), Asthma and during Viruses induced lung injury. My postdoctoral research work has identified a novel association of club cells with specific protein disulfide isomerases (PDIs) in pulmonary fibrosis and demonstrated that ablation or inhibition of PDIA3 within club cells decreases bleomycin-induced lung fibrosis in mice. This study revealed a new relationship with distally localized club cells, PDIA3 and SPP1 in lung fibrosis and inhibition of PDIA3 or SPP1 attenuates lung fibrosis. In continuous with this work, I found that PDIA3 and osteopontin (SPP1) promotes IAV-induced lung fibrosis and inhibiting PDIA3/SPP1 axis resolves IAV-mediated fibrotic sequela.
The pathological functions of club cell-PDI association in virus-induced fibrotic sequela remain unknown and characterizing this association will be the focus of my future research. I am also studying the role of MUC5B in PF which is a known risk factor for the development of IPF, particularly due to its association with mucus overproduction and the formation of mucus plugs which can exacerbate lung damage. Preliminary results from our research find that MUC5B overexpression influences the development of PF and ER stress chaperones PDIAs play an important role in manipulating MUC5B expression in PF.
During my PhD, I carried out studies designing peptides/peptidomimetics of pharmacological importance. I identified leucine zipper like sequences in antimicrobial peptide Piscidin-1 for the first time and demonstrated its crucial roles in cytotoxic and anti-endotoxin activities.
Publications
Bio
My research interests have focused on catching the mediators involved in various lung diseases like Pulmonary Fibrosis (PF), Asthma and during Viruses induced lung injury. My postdoctoral research work has identified a novel association of club cells with specific protein disulfide isomerases (PDIs) in pulmonary fibrosis and demonstrated that ablation or inhibition of PDIA3 within club cells decreases bleomycin-induced lung fibrosis in mice. This study revealed a new relationship with distally localized club cells, PDIA3 and SPP1 in lung fibrosis and inhibition of PDIA3 or SPP1 attenuates lung fibrosis. In continuous with this work, I found that PDIA3 and osteopontin (SPP1) promotes IAV-induced lung fibrosis and inhibiting PDIA3/SPP1 axis resolves IAV-mediated fibrotic sequela.
The pathological functions of club cell-PDI association in virus-induced fibrotic sequela remain unknown and characterizing this association will be the focus of my future research. I am also studying the role of MUC5B in PF which is a known risk factor for the development of IPF, particularly due to its association with mucus overproduction and the formation of mucus plugs which can exacerbate lung damage. Preliminary results from our research find that MUC5B overexpression influences the development of PF and ER stress chaperones PDIAs play an important role in manipulating MUC5B expression in PF.
During my PhD, I carried out studies designing peptides/peptidomimetics of pharmacological importance. I identified leucine zipper like sequences in antimicrobial peptide Piscidin-1 for the first time and demonstrated its crucial roles in cytotoxic and anti-endotoxin activities.
Publications
2022 Postdoctoral Research, Unfolded Protein Response in Respiratory Diseases, University of Vermont Larner College of Medicine, Burlington, VT