Research

A unique aspect of the CMB Program is the interdisciplinary structure of the individual faculty research projects, which are often highly collaborative and cross traditional department boundaries. CMB faculty have primary appointments in clinical as well as basic science departments, which brings a broad perspective of contemporary problems in cell, molecular and biomedical sciences. CMB graduate students have instant exposure to this vast array of research to learn skills directly from experts to apply toward their PhD research.

The research enterprise within the CMB Program is well-funded by extramural support with 60 million grant dollars generated annually by the CMB faculty in individual research awards, program projects grants, and pre- and post-doctoral training grants. Large interdisciplinary, multi-investigator grants fund research projects in cancer biology, cardiovascular biology and cell motility, environmental pathology, immunobiology, neuroscience, and pulmonary function and disease. In addition, students have access to cutting-edge core facilities including those in Bioinformatics, X-Ray Crystallography, DNA Analysis, Flow Cytometry, and Microscopy and Imaging.

Faculty Research Areas

Cancer Biology and Genome Stability

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NameAreas of Expertise and/or Research
Frances CarrCellular events which mediate thyroid hormone action in development and pathophysiology
Nimrat ChatterjeeCancer Biology, Neurodegenerative disorders, DNA repair, translesion synthesis, stress responses
Brian CunniffMitochondrial biology, cancer metabolism, cell migration and redox biology
Paula DemingMolecular Signaling Mechanisms, Growth Control Pathways, Cancer Biology
Sylvie DoublieMolecular Mechanisms of DNA Repair
Christopher FrancklynProtein Synthesis in Biological Regulation and Human Disease
Seth FrietzeMolecular Biology, Genomics, Cancer Biology
Karen GlassStructure and function of epigenetic reader domains
Jessica HeathPediatric Leukemias: epigenetics, mechanisms of leukemogenesis, and novel treatment development
Alan HoweRegulation of cell migration by extracellular matrix
Robert KelmRegulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Christopher LandryMaterials Chemistry, Nanotechnology, and Particles in Biology
Shanmugasundaram NallasamyExtracellular matrix dysfunction in uterine leiomyoma and leiomyosarcoma
David SewardFunctional Genomics, Cancer Metabolism, Epigenetics
Gary SteinCancer, Stem Cell and Bone Biology Program
Janet SteinRegulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason StumpffMolecular Control of Cell Division
Michael TothTranslational studies of human skeletal muscle structure and function

Genomics and Computational Biology

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NameAreas of Expertise and/or Research
Sylvie DoublieMolecular Mechanisms of DNA Repair
Andrea EtterFood safety, food microbiology, bacterial stress tolerance, bacterial genetics
Seth FrietzeMolecular Biology, Genomics, Cancer Biology
Karen GlassStructure and function of epigenetic reader domains
Jonathan GordonEpigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions
Dev MajumdarRNA Biology, Immunology, Single Molecule Biophysics
Shanmugasundaram NallasamySmall non-coding RNAs regulating myometrial extracellular matrix
Gary SteinCancer, Stem Cell and Bone Biology Program
Janet SteinRegulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition

Immunology and Microbial Pathogenesis

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NameAreas of Expertise and/or Research
Eyal AmielMetabolic Regulation of Dendritic Cell Activation and Immune Function
John BarlowMathematical and molecular epidemiology of infectious disease; Host-Pathogen interactions in mastitis; Cattle MHC
Elizabeth BonneyMaternal immunity and tolerance
Jason BottenHost immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines
Jonathan BoysonThe regulation and function of innate-like T cells
Emily BruceCell biology and molecular virology of RNA viruses (SARS-CoV-2 and influenza)
Jean CelliCellular and molecular mechanisms of proliferation of intracellular bacterial pathogens; Brucella pathogenesis;Type IV secretion; intracellular organelle biology
Sean DiehlVaccines and immunology
Andrea EtterFood safety, food microbiology, bacterial stress tolerance, bacterial genetics
Seth FrietzeMolecular Biology, Genomics, Cancer Biology
Christopher HustonHost-Pathogen Interactions of Intestinal Protozoa
Leigh KnowlderBacteria-host interactions; Enteric bacteria
Dimitry KrementsovAutoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome
Benjamin LeeEnteric viral infections and immunology, vaccines
Dev MajumdarRNA Biology, Immunology, Single Molecule Biophysics
Bruno Martorelli Di GenovaParasitology and Microbiology
Matthew PoynterAirway epithelium in innate and adaptive immune responses
Markus ThaliMultiscale analyses of HIV-1 cell-to-cell transmission
Gary WardCell Biology of Host-Parasite Interaction
Matthew WargoRegulation of Bacterial Virulence and Catabolism
Daniel WeissGene and stem cell therapies for lung diseases

Lung and Cardiovascular Biology

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NameAreas of Expertise and/or Research
Vikas AnathyEndoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases
Frances CarrCellular events which mediate thyroid hormone action in development and pathophysiology
Brian CunniffMitochondrial biology, cancer metabolism, cell migration and redox biology
Benedek ErdosNeural control of cardiovascular function; stress, obesity and aging
Stephen EverseStructure and Function of Proteins
Kalev FreemanTrauma physiology/ traumatic brain injury
Yvonne Janssen-HeiningerTranscriptional regulators of lung responses to injury and inflammation
Robert KelmRegulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Karen LounsburyVascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis
Mark NelsonIon channels and calcium signaling in smooth muscle and endothelial cells
Matthew PoynterAirway epithelium in innate and adaptive immune responses
Jay SilveiraBiochemistry of Platelet Function
Jeff SpeesAdult Stem Cell Biology and Regenerative Medicine
Michael TothTranslational studies of human skeletal muscle structure and function
Albert van der VlietBiological and environmental oxidants and airway inflammation: Mechanisms of redox signaling
Matthew WargoRegulation of Bacterial Virulence and Catabolism
David WarshawMyosin Molecular Motors
Daniel WeissGene and stem cell therapies for lung diseases

Molecular Cell Biology and Genetics

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NameAreas of Expertise and/or Research
Vikas AnathyEndoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases
Jason BottenHost immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines
Bryan BallifSignal Transduction, Proteomics, Neuroscience
Emily BruceCell biology and molecular virology of RNA viruses (SARS-CoV-2 and influenza)
Ralph BuddDeath receptor regulation of apoptosis in the immune system
Benedek ErdosNeural control of cardiovascular function; stress, obesity and aging
Alan HoweRegulation of cell migration by extracellular matrix
Yvonne Janssen-HeiningerTranscriptional regulators of lung responses to injury and inflammation
Thomas JettonMechanisms that regulate the development, growth, and regeneration of pancreatic beta cells
Robert KelmRegulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Dimitry KrementsovAutoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome
Karen LounsburyVascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis
Dev MajumdarRNA Biology, Immunology, Single Molecule Biophysics
Shanmugasundaram NallasamyStructure and function of extracellular matrix in term and preterm birth
Michael PrevisMolecular mechanisms of muscle
Delphine QuenetPARP biology and chromatin
John SalogiannisMolecular mechanisms and live cell imaging of intracellular organelle movement in health and disease"
David SewardFunctional Genomics, Cancer Metabolism, Epigenetics
Jeff SpeesAdult Stem Cell Biology and Regenerative Medicine
Gary SteinCancer, Stem Cell and Bone Biology Program
Janet SteinRegulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason StumpffMolecular Control of Cell Division
Doug TaatjesCell imaging and disease
Markus ThaliMultiscale analyses of HIV-1 cell-to-cell transmission
Mary TierneyMechanisms for controlling cell function through ECM structure
Michael TothTranslational studies of human skeletal muscle structure and function
Albert van der VlietBiological and environmental oxidants and airway inflammation: Mechanisms of redox signaling
Gary WardCell Biology of Host-Parasite Interaction
Matthew WargoRegulation of Bacterial Virulence and Catabolism

Stem Cell And Developmental Biology

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NameAreas of Expertise and/or Research
Bryan BallifSignal Transduction, Proteomics, Neuroscience
Elizabeth BonneyMaternal immunity and tolerance
Jonathan GordonEpigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions
Thomas JettonMechanisms that regulate the development, growth, and regeneration of pancreatic beta cells
Jeff SpeesAdult Stem Cell Biology and Regenerative Medicine
James StaffordEpigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory
Gary SteinCancer, Stem Cell and Bone Biology Program
Janet SteinRegulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason StumpffMolecular Control of Cell Division
Mary TierneyMechanisms for controlling cell function through ECM structure
Daniel WeissGene and stem cell therapies for lung diseases.

Structural Biology and Biophysics

Body
NameAreas of Expertise and/or Research
Frances CarrCellular events which mediate thyroid hormone action in development and pathophysiology
Nimrat ChatterjeeCancer Biology, Neurodegenerative disorders, DNA repair, translesion synthesis, stress responses
Brian CunniffMitochondrial biology, cancer metabolism, cell migration and redox biology
Paula DemingMolecular Signaling Mechanisms, Growth Control Pathways, Cancer Biology
Sylvie DoublieMolecular Mechanisms of DNA Repair
Seth FrietzeMolecular Biology, Genomics, Cancer Biology
Karen GlassStructure and function of epigenetic reader domains
Jessica HeathPediatric Leukemias: epigenetics, mechanisms of leukemogenesis, and novel treatment development
Robert HondalMechanism of Thioredoxin Reductase — a Collaborative Project
Alan HoweRegulation of cell migration by extracellular matrix
Robert KelmRegulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Christopher LandryMaterials Chemistry, Nanotechnology, and Particles in Biology
Karen LounsburyVascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis
Shanmugasundaram NallasamyExtracellular matrix dysfunction in uterine leiomyoma and leiomyosarcoma
David PedersonDNA Replication and Repair in Chromatin
Delphine QuenetPARP Biology and Chromatin
David SewardFunctional Genomics, Cancer Metabolism, Epigenetics
Gary SteinCancer, Stem Cell and Bone Biology Program
Janet SteinRegulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason StumpffMolecular Control of Cell Division
Michael TothTranslational studies of human skeletal muscle structure and function