The research enterprise in the CMB Program is well-funded by extramural support in the form of individual research awards, program projects grants, and pre- and post-doctoral training grants. Funding sources include the National Institutes of Health, National Science Foundation, American Heart Association, USDA, DOD and NASA. Large interdisciplinary, multi-investigator grants fund research projects in cancer biology, cardiovascular biology and cell motility, environmental pathology, immunobiology, neuroscience, and pulmonary function and disease.
In addition, students have access to cutting-edge equipment and focused training in our core facilities. These facilities include the Bioinformatics, X-Ray Crystallography, DNA Analysis, Flow Cytometry, and Microscopy and Imaging.
Note: Faculty listed below have self identified their participation in these areas, and may be listed in multiple categories. For an alphabetical list of faculty, please visit the faculty directory.
Faculty Research Listed by Topic Area
- Cancer Biology and Genome Stability
- Genomics and Computational Biology
- Immunology and Microbial Pathogenesis
- Lung and Cardiovascular Biology
- Molecular Cell Biology and Genetics
- Stem Cell And Developmental Biology
- Structural Biology and Biophysics
| Name | Areas of Expertise and/or Research |
|---|---|
| Ralph Budd | Death receptor regulation of apoptosis in the immune system |
| Frances Carr | Cellular events which mediate thyroid hormone action in development and pathophysiology |
| Nimrat Chatterjee | Cancer Biology, Neurodegenerative disorders, DNA repair, translesion synthesis, stress responses |
| Jaeda Coutinho-Budd | Glial development and neuron-glia signaling |
| Brian Cunniff | Mitochondrial biology, cancer metabolism, cell migration and redox biology |
| Paula Deming | Molecular Signaling Mechanisms, Growth Control Pathways, Cancer Biology |
| Sylvie Doublie | Molecular Mechanisms of DNA Repair |
| Christopher Francklyn | Protein Synthesis in Biological Regulation and Human Disease |
| Seth Frietze | Molecular Biology, Genomics, Cancer Biology |
| Karen Glass | Structure and function of epigenetic reader domains |
| Jessica Heath | Pediatric Leukemias: epigenetics, mechanisms of leukemogenesis, and novel treatment development |
| Robert Hondal | Mechanism of Thioredoxin Reductase — a Collaborative Project |
| Alan Howe | Regulation of cell migration by extracellular matrix |
| Robert Kelm | Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins |
| Christopher Landry | Materials Chemistry, Nanotechnology, and Particles in Biology |
| Andrea Lee | DNA Repair |
| Jane Lian | Bone biology and pathogenesis |
| Karen Lounsbury | Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis |
| Scott Morrical | DNA Repair- structure and function of protein-DNA complexes |
| Shanmugasundaram Nallasamy | Extracellular matrix dysfunction in uterine leiomyoma and leiomyosarcoma |
| David Pederson | DNA Replication and Repair in Chromatin |
| Delphine Quenet | PARP Biology and Chromatin |
| Severin Schneebeli | Design and Synthesis of Biologically-active Molecules and Artificial Antibodies; Supramolecular Chemistry; Computational Chemistry |
| James Stafford | Epigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory |
| David Seward | Functional Genomics, Cancer Metabolism, Epigenetics |
| Arti Shukla | Understanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies |
| Girja Shukla | Cancer-specific affinity molecules for diagnosis and targeted therapy |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Janet Stein | Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition |
| Jason Stumpff | Molecular Control of Cell Division |
| Michael Toth | Translational studies of human skeletal muscle structure and function |
| Feng-Qi Zhao | Lactation physiology, mammary gland biology, breast cancer, and endocrine regulation |
| Name | Areas of Expertise and/or Research |
|---|---|
| Sylvie Doublie | Molecular Mechanisms of DNA Repair |
| Andrea Etter | Food safety, food microbiology, bacterial stress tolerance, bacterial genetics |
| Seth Frietze | Molecular Biology, Genomics, Cancer Biology |
| Karen Glass | Structure and function of epigenetic reader domains |
| Jonathan Gordon | Epigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions |
| Jane Lian | Bone biology and pathogenesis |
| Dev Majumdar | RNA Biology, Immunology, Single Molecule Biophysics |
| Stephanie McKay | Livestock Genetics, Genomics, Epigenetics and Epigenomics |
| Shanmugasundaram Nallasamy | Small non-coding RNAs regulating myometrial extracellular matrix |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Janet Stein | Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition |
| Name | Areas of Expertise and/or Research |
|---|---|
| Eyal Amiel | Metabolic Regulation of Dendritic Cell Activation and Immune Function |
| John Barlow | Mathematical and molecular epidemiology of infectious disease; Host-Pathogen interactions in mastitis; Cattle MHC |
| Elizabeth Bonney | Maternal immunity and tolerance |
| Jason Botten | Host immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines |
| Jonathan Boyson | The regulation and function of innate-like T cells |
| Emlily Bruce | Cell biology and molecular virology of RNA viruses (SARS-CoV-2 and influenza) |
| Ralph Budd | Death receptor regulation of apoptosis in the immune system |
| Jean Celli | Cellular and molecular mechanisms of proliferation of intracellular bacterial pathogens; Brucella pathogenesis;Type IV secretion; intracellular organelle biology |
| Sean Diehl | Vaccines and immunology |
| Andrea Etter | Food safety, food microbiology, bacterial stress tolerance, bacterial genetics |
| Seth Frietze | Molecular Biology, Genomics, Cancer Biology |
| Christopher Huston | Host-Pathogen Interactions of Intestinal Protozoa |
| Charles Irvin | Asthma Pathogenesis, respiratory physiology and airway biology |
| Leigh Knolder | Bacteria-host interactions; Enteric bacteria |
| Dimitry Krementsov | Autoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome |
| Benjamin Lee | Enteric viral infections and immunology, vaccines |
| Dev Majumdar | RNA Biology, Immunology, Single Molecule Biophysics |
| Bruno Martorelli Di Genova | Parasitology & Microbiology |
| Matthew Poynter | Airway epithelium in innate and adaptive immune responses |
| Girja Shukla | Cancer-specific affinity molecules for diagnosis and targeted therapy |
| Cory Teuscher | Genetics of susceptibility to infectious and autoimmune disease |
| Markus Thali | Multiscale analyses of HIV-1 cell-to-cell transmission |
| Gary Ward | Cell Biology of Host-Parasite Interaction |
| Matthew Wargo | Regulation of Bacterial Virulence and Catabolism |
| Daniel Weiss | Gene and stem cell therapies for lung diseases |
| Name | Areas of Expertise and/or Research |
|---|---|
| Vikas Anathy | Endoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases |
| Beth Bouchard | Mechanisms regulating factor V endocytosis by megakaryocytes |
| Frances Carr | Cellular events which mediate thyroid hormone action in development and pathophysiology |
| Brian Cunniff | Mitochondrial biology, cancer metabolism, cell migration and redox biology |
| Wolfgang Dostmann | cGMP/PKG signaling in vascular smooth muscle; Pharmacology |
| Benedek Erdos | Neural control of cardiovascular function; stress, obesity and aging |
| Stephen Everse | Structure & Function of Proteins |
| Kalev Freeman | Trauma physiology/ traumatic brain injury |
| Charles Irvin | Asthma Pathogenesis, respiratory physiology and airway biology. |
| Yvonne Janssen-Heininger | Transcriptional regulators of lung responses to injury and inflammation |
| Robert Kelm | Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins |
| Karen Lounsbury | Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis |
| Mark Nelson | Ion channels and calcium signaling in smooth muscle and endothelial cells |
| Matthew Poynter | Airway epithelium in innate and adaptive immune responses |
| Arti Shukla | Understanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies |
| Jay Silveira | Biochemistry of Platelet Function |
| Jeff Spees | Adult Stem Cell Biology and Regenerative Medicine |
| Doug Taatjes | Cell imaging and disease |
| Cory Teuscher | Genetics of susceptibility to infectious and autoimmune disease |
| Michael Toth | Translational studies of human skeletal muscle structure and function |
| Kathleen Trybus | Molecular motors and their tracks |
| Albert van der Vliet | Biological and environmental oxidants and airway inflammation: Mechanisms of redox signaling |
| Jim Vigoreaux | Biology of insect flight muscle and vertebrate cardiac muscle |
| Matthew Wargo | Regulation of Bacterial Virulence and Catabolism |
| David Warshaw | Myosin Molecular Motors |
| Daniel Weiss | Gene and stem cell therapies for lung diseases |
| George Wellman | Cerebral artery function in health and disease |
| Name | Areas of Expertise and/or Research |
|---|---|
| Vikas Anathy | Endoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases |
| Jason Botten | Host immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines |
| Bryan Ballif | Signal Transduction, Proteomics, Neuroscience |
| Emily Bruce | Cell biology and molecular virology of RNA viruses (SARS-CoV-2 and influenza) |
| Ralph Budd | Death receptor regulation of apoptosis in the immune system |
| Jaeda Coutinho-Budd | Glial development and neuron-glia signaling |
| Wolfgang Dostmann | cGMP/PKG signaling in vascular smooth muscle; Pharmacology |
| Benedek Erdos | Neural control of cardiovascular function; stress, obesity and aging |
| Alan Howe | Regulation of cell migration by extracellular matrix |
| Yvonne Janssen-Heininger | Transcriptional regulators of lung responses to injury and inflammation |
| Thomas Jetton | Mechanisms that regulate the development, growth, and regeneration of pancreatic beta cells |
| Robert Kelm | Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins |
| Jana Kraft | Nutrition; dietary fatty acids in health and disease; fatty acid metabolism in humans and rumen microbiota |
| Dimitry Krementsov | Autoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome |
| Jane Lian | Bone biology and pathogenesis |
| Karen Lounsbury | Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis |
| Dev Majumdar | RNA Biology, Immunology, Single Molecule Biophysics |
| Stephanie McKay | Livestock Genetics, Genomics, Epigenetics and Epigenomics |
| Anthony Morielli | Molecular mechanisms of ion channel regulation in the brain |
| Shanmugasundaram Nallasamy | Structure and function of extracellular matrix in term and preterm birth |
| Michael Previs | Molecular mechanisms of muscle |
| Delphine Quenet | PARP biology and chromatin |
| Severin Schneebeli | Design and Synthesis of Biologically-active Molecules and Artificial Antibodies; Supramolecular Chemistry; Computational Chemistry |
| David Seward | Functional Genomics, Cancer Metabolism, Epigenetics |
| Arti Shukla | Understanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies |
| Jeff Spees | Adult Stem Cell Biology and Regenerative Medicine |
| James Stafford | Epigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Janet Stein | Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition |
| Jason Stumpff | Molecular Control of Cell Division |
| Doug Taatjes | Cell imaging and disease |
| Eric Testroet | Nutrigenomic regulation of hepatic lipid partitioning in human and animals, extracellular vesicle role in growth and immune modulation, nutritional physiology |
| Markus Thali | Multiscale analyses of HIV-1 cell-to-cell transmission |
| Mary Tierney | Mechanisms for controlling cell function through ECM structure |
| Michael Toth | Translational studies of human skeletal muscle structure and function |
| Albert van der Vliet | Biological and environmental oxidants and airway inflammation: Mechanisms of redox signaling |
| Jim Vigoreaux | Biology of insect flight muscle and vertebrate cardiac muscle |
| Gary Ward | Cell Biology of Host-Parasite Interaction |
| Matthew Wargo | Regulation of Bacterial Virulence and Catabolism |
| Feng-Qi Zhao | Lactation physiology, mammary gland biology, breast cancer, and endocrine regulation |
| Name | Areas of Expertise and/or Research |
|---|---|
| Bryan Ballif | Signal Transduction, Proteomics, Neuroscience |
| Elizabeth Bonney | Maternal immunity and tolerance |
| Jaeda Coutinho-Budd | Glial development and neuron-glia signaling |
| Jonathan Gordon | Epigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions |
| Thomas Jetton | Mechanisms that regulate the development, growth, and regeneration of pancreatic beta cells |
| Jane Lian | Bone biology and pathogenesis |
| Jeff Spees | Adult Stem Cell Biology and Regenerative Medicine |
| James Stafford | Epigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Janet Stein | Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition |
| Jason Stumpff | Molecular Control of Cell Division |
| Eric Testroet | Nutrigenomic regulation of hepatic lipid partitioning in human and animals, extracellular vesicle role in growth and immune modulation, nutritional physiology |
| Mary Tierney | Mechanisms for controlling cell function through ECM structure |
| Daniel Weiss | Gene and stem cell therapies for lung diseases. |
| Name | Areas of Expertise and/or Research |
|---|---|
| Christopher Berger | Molecular Mechanisms of Axonal Transport |
| Wolfgang Dostmann | cGMP/PKG signaling in vascular smooth muscle; Pharmacology |
| Sylvie Doublie | X-Ray Crystallography |
| Stephen Everse | Structure & Function of Proteins |
| Christopher Francklyn | Structure and Function of Nucleic Acid Binding Proteins |
| Karen Glass | Structure and function of epigenetic reader domains |
| Robert Hondal | Mechanism of Thioredoxin Reductase — a Collaborative Project |
| Robert Kelm | Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins |
| Andrea Lee | DNA Repair |
| Jianing Li | Multiscale modeling of biological macromolecules |
| Dwight Matthews | Analytical and clinical applications of mass spectrometry |
| Scott Morrical | DNA Repair- structure and function of protein-DNA complexes |
| Shanmugasundaram Nallasamy | Mechanical function of the myometrium during pregnancy and parturition |
| Mark Nelson | Ion channels and calcium signaling in smooth muscle and endothelial cells |
| David Pederson | DNA Replication and Repair in Chromatin |
| Michael Previs | Molecular mechanisms of muscle |
| Gary Stein | Cancer, Stem Cell and Bone Biology Program |
| Jason Stumpff | Molecular Control of Cell Division |
| Kathleen Trybus | Molecular motors and their tracks |
| David Warshaw | Myosin Molecular Motors |