Checking out films in the lab

A unique aspect of the CMB Program is the interdisciplinary nature of the individual research projects, which are often highly collaborative and cross traditional department boundaries. A number of participating faculty have primary appointments in clinical as well as basic science departments, bringing a broad perspective of contemporary problems in cell, molecular and biomedical sciences.

The research enterprise in the CMB Program is well-funded by extramural support in the form of individual research awards, program projects grants, and pre- and post-doctoral training grants. Funding sources include the National Institutes of Health, National Science Foundation, American Heart Association, USDA, DOD and NASA. Large interdisciplinary, multi-investigator grants fund research projects in cancer biology, cardiovascular biology and cell motility, environmental pathology, immunobiology, neuroscience, and pulmonary function and disease.

In addition, students have access to cutting-edge equipment and focused training in our core facilities. These facilities include the Bioinformatics, X-Ray Crystallography, DNA Analysis, Flow Cytometry, Microscopy and Imaging, and Transgenic Mice cores.

Note: Faculty listed below have self identified their participation in these areas, and may be listed in multiple categories. For an alphabetical list of faculty, please visit the faculty directory.

Faculty Research Listed by Topic Area

 

Cancer Biology and Genome Stability
NameAreas of Expertise and/or Research
Ralph BuddDeath receptor regulation of apoptosis in the immune system
Frances CarrCellular events which mediate thyroid hormone action in development and pathophysiology
Nimrat ChatterjeeCancer Biology, Neurodegenerative disorders, DNA repair, translesion synthesis, stress responses
Jaeda Coutinho-BuddGlial development and neuron-glia signaling
Brian CunniffMitochondrial biology, cancer metabolism, cell migration and redox biology
Paula DemingMolecular Signaling Mechanisms, Growth Control Pathways, Cancer Biology
Sylvie DoublieX-Ray Crystallography
Christopher FrancklynProtein Synthesis in Biological Regulation and Human Disease
Seth FrietzeMolecular Biology, Genomics, Cancer Biology
Karen GlassStructure and function of epigenetic reader domains
Jessica HeathPediatric Leukemias: epigenetics, mechanisms of leukemogenesis, and novel treatment development
Robert HondalMechanism of Thioredoxin Reductase — a Collaborative Project
Alan HoweRegulation of cell migration by extracellular matrix
Robert KelmRegulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Christopher LandryMaterials Chemistry, Nanotechnology, and Particles in Biology
Andrea LeeDNA Repair
Jane LianBone biology and pathogenesis
Karen LounsburyVascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis
Scott MorricalDNA Repair- structure and function of protein-DNA complexes
Shanmugasundaram NallasamyExtracellular matrix dysfunction in uterine leiomyoma and leiomyosarcoma
David PedersonDNA Replication and Repair in Chromatin
Delphine QuenetPARP Biology and Chromatin
Severin SchneebeliDesign and Synthesis of Biologically-active Molecules and Artificial Antibodies; Supramolecular Chemistry; Computational Chemistry
James StaffordEpigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory
David SewardFunctional Genomics, Cancer Metabolism, Epigenetics
Arti ShuklaUnderstanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies
Girja ShuklaCancer-specific affinity molecules for diagnosis and targeted therapy
Gary SteinCancer, Stem Cell and Bone Biology Program
Janet SteinRegulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason StumpffMolecular Control of Cell Division
Michael TothTranslational studies of human skeletal muscle structure and function
Feng-Qi ZhaoLactation physiology, mammary gland biology, breast cancer, and endocrine regulation

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Genomics and Computational Biology
NameAreas of Expertise and/or Research
Sylvie DoublieX-Ray Crystallography
Andrea EtterFood safety, food microbiology, bacterial stress tolerance, bacterial genetics
Seth FrietzeMolecular Biology, Genomics, Cancer Biology
Karen GlassStructure and function of epigenetic reader domains
Jonathan GordonEpigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions
Dawei LiHuman Genetics and Genomics
Jane LianBone biology and pathogenesis
Shanmugasundaram NallasamySmall non-coding RNAs regulating myometrial extracellular matrix
Gary SteinCancer, Stem Cell and Bone Biology Program
Janet SteinRegulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition

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Immunology and Microbial Pathogenesis
NameAreas of Expertise and/or Research
Eyal AmielMetabolic Regulation of Dendritic Cell Activation and Immune Function
John BarlowMathematical and molecular epidemiology of infectious disease; Host-Pathogen interactions in mastitis; Cattle MHC
Elizabeth BonneyMaternal immunity and tolerance
Jason BottenHost immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines
Jonathan BoysonThe regulation and function of innate-like T cells
Ralph BuddDeath receptor regulation of apoptosis in the immune system
Sean DiehlVaccines and immunology
Andrea EtterFood safety, food microbiology, bacterial stress tolerance, bacterial genetics
Seth FrietzeMolecular Biology, Genomics, Cancer Biology
Christopher HustonHost-Pathogen Interactions of Intestinal Protozoa
Charlie (Charles) IrvinAsthma Pathogenesis, respiratory physiology and airway biology
Dimitry KrementsovAutoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome
Benjamin LeeEnteric viral infections and immunology, vaccines
Matthew PoynterAirway epithelium in innate and adaptive immune responses
Girja ShuklaCancer-specific affinity molecules for diagnosis and targeted therapy
Cory TeuscherGenetics of susceptibility to infectious and autoimmune disease
Markus ThaliMultiscale analyses of HIV-1 cell-to-cell transmission
Gary WardCell Biology of Host-Parasite Interaction
Matthew WargoRegulation of Bacterial Virulence and Catabolism
Daniel WeissGene and stem cell therapies for lung diseases

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Lung and Cardiovascular Biology
NameAreas of Expertise and/or Research
Vikas AnathyEndoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases
Beth BouchardMechanisms regulating factor V endocytosis by megakaryocytes
Frances CarrCellular events which mediate thyroid hormone action in development and pathophysiology
Brian CunniffMitochondrial biology, cancer metabolism, cell migration and redox biology
Wolfgang DostmanncGMP/PKG signaling in vascular smooth muscle; Pharmacology
Benedek ErdosNeural control of cardiovascular function; stress, obesity and aging
Stephen EverseStructure & Function of Proteins
Kalev FreemanTrauma physiology/ traumatic brain injury
Charlie (Charles) IrvinAsthma Pathogenesis, respiratory physiology and airway biology.
Yvonne Janssen-HeiningerTranscriptional regulators of lung responses to injury and inflammation
Robert KelmRegulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Karen LounsburyVascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis
Matthew PoynterAirway epithelium in innate and adaptive immune responses
Arti ShuklaUnderstanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies
Jay SilveiraBiochemistry of Platelet Function
Jeff SpeesAdult Stem Cell Biology and Regenerative Medicine
Doug TaatjesCell imaging and disease
Cory TeuscherGenetics of susceptibility to infectious and autoimmune disease
Michael TothTranslational studies of human skeletal muscle structure and function
Kathleen TrybusMolecular motors and their tracks
Albert van der VlietBiological and environmental oxidants and airway inflammation: Mechanisms of redox signaling
Jim VigoreauxBiology of insect flight muscle and vertebrate cardiac muscle
Matthew WargoRegulation of Bacterial Virulence and Catabolism
David WarshawMyosin Molecular Motors
Daniel WeissGene and stem cell therapies for lung diseases
George WellmanCerebral artery function in health and disease

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Molecular Cell Biology and Genetics
NameAreas of Expertise and/or Research
Vikas AnathyEndoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases
Jason BottenHost immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines
Ralph BuddDeath receptor regulation of apoptosis in the immune system
Jaeda Coutinho-BuddGlial development and neuron-glia signaling
Wolfgang DostmanncGMP/PKG signaling in vascular smooth muscle; Pharmacology
Benedek ErdosNeural control of cardiovascular function; stress, obesity and aging
Amanda HernanPediatric epilepsy, neurodevelopmental disorders, cognition, neuropeptides, electrophysiology
Alan HoweRegulation of cell migration by extracellular matrix
Yvonne Janssen-HeiningerTranscriptional regulators of lung responses to injury and inflammation
Thomas JettonMechanisms that regulate the development, growth, and regeneration of pancreatic beta cells
Robert KelmRegulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Jana KraftNutrition; dietary fatty acids in health and disease; fatty acid metabolism in humans and rumen microbiota
Dimitry KrementsovAutoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome
Jane LianBone biology and pathogenesis
Karen LounsburyVascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis
Anthony MorielliMolecular mechanisms of ion channel regulation in the brain
Shanmugasundaram NallasamyStructure and function of extracellular matrix in term and preterm birth
Michael J. PrevisMolecular mechanisms of muscle
Delphine QuenetPARP biology and chromatin
Severin SchneebeliDesign and Synthesis of Biologically-active Molecules and Artificial Antibodies; Supramolecular Chemistry; Computational Chemistry
David SewardFunctional Genomics, Cancer Metabolism, Epigenetics
Arti ShuklaUnderstanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies
Jeff SpeesAdult Stem Cell Biology and Regenerative Medicine
James StaffordEpigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory
Gary SteinCancer, Stem Cell and Bone Biology Program
Janet SteinRegulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason StumpffMolecular Control of Cell Division
Doug TaatjesCell imaging and disease
Eric TestroetNutrigenomic regulation of hepatic lipid partitioning in human and animals, extracellular vesicle role in growth and immune modulation, nutritional physiology
Markus ThaliMultiscale analyses of HIV-1 cell-to-cell transmission
Mary TierneyMechanisms for controlling cell function through ECM structure
Michael TothTranslational studies of human skeletal muscle structure and function
Albert van der VlietBiological and environmental oxidants and airway inflammation: Mechanisms of redox signaling
Jim VigoreauxBiology of insect flight muscle and vertebrate cardiac muscle
Gary WardCell Biology of Host-Parasite Interaction
Matthew WargoRegulation of Bacterial Virulence and Catabolism
Feng-Qi ZhaoLactation physiology, mammary gland biology, breast cancer, and endocrine regulation

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Stem Cell And Developmental Biology
NameAreas of Expertise and/or Research
Elizabeth BonneyMaternal immunity and tolerance
Jaeda Coutinho-BuddGlial development and neuron-glia signaling
Jonathan GordonEpigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions
Amanda HernanPediatric epilepsy, neurodevelopmental disorders, cognition, neuropeptides, electrophysiology
Thomas JettonMechanisms that regulate the development, growth, and regeneration of pancreatic beta cells
Jane LianBone biology and pathogenesis
Jeff SpeesAdult Stem Cell Biology and Regenerative Medicine
James StaffordEpigenetics in the brain, diseases of neurodevelopment, alcohol use disorders, brain tumors, learning and memory
Gary SteinCancer, Stem Cell and Bone Biology Program
Janet SteinRegulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason StumpffMolecular Control of Cell Division
Eric TestroetNutrigenomic regulation of hepatic lipid partitioning in human and animals, extracellular vesicle role in growth and immune modulation, nutritional physiology
Mary TierneyMechanisms for controlling cell function through ECM structure
Daniel WeissGene and stem cell therapies for lung diseases.

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Structural Biology and Biophysics
NameAreas of Expertise and/or Research
Christopher BergerMolecular Mechanisms of Axonal Transport
Wolfgang DostmanncGMP/PKG signaling in vascular smooth muscle; Pharmacology
Sylvie DoublieX-Ray Crystallography
Stephen EverseStructure & Function of Proteins
Christopher FrancklynStructure and Function of Nucleic Acid Binding Proteins
Karen GlassStructure and function of epigenetic reader domains
Robert HondalMechanism of Thioredoxin Reductase — a Collaborative Project
Robert KelmRegulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Andrea LeeDNA Repair
Jianing LiMultiscale modeling of biological macromolecules
Dwight MatthewsAnalytical and clinical applications of mass spectrometry
Scott MorricalDNA Repair- structure and function of protein-DNA complexes
Shanmugasundaram NallasamyMechanical function of the myometrium during pregnancy and parturition
David PedersonDNA Replication and Repair in Chromatin
Michael J. PrevisMolecular mechanisms of muscle
Gary SteinCancer, Stem Cell and Bone Biology Program
Jason StumpffMolecular Control of Cell Division
Kathleen TrybusMolecular motors and their tracks
David WarshawMyosin Molecular Motors

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