Kalev Freeman
Professor, Emergency Medicine and Pharmacology
Emergency Physician
Larner College of Medicine
Firestone Medical Research Building, Room 452
149 Beaumont Ave
Burlington, VT 05405
United States
- M.D., Medical Scientist Training Program, University of Colorado
- Ph.D., Molecular Biology, University of Colorado
- B.S., Celluar & Molecular Biology, University of Michigan
- Residency, Emergency Medicine, Boston University
- Internship, Surgery, University of Colorado
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Areas of expertise
emergency medicine, trauma, inflammation, vascular biology, endothelial cells, coagulation biochemistry, ion channels, pharmacology.
BIO
Kalev Freeman is a physician scientist whose research aims to improve outcomes for victims of trauma. Dr. Freeman leads an NIH-funded research program focused on one of the most urgent challenges in trauma surgery: the acute endotheliopathy that underlies multiorgan failure in critical illness and shock. Seminal work from his laboratory showed that circulating factors activate endothelial cells to drive thrombo-inflammation and microvascular dysfunction in severe trauma. His team also provided pivotal early-stage evidence that led to the development of modern diagnostic tools and resuscitation protocols for trauma-induced coagulopathy.
Courses
- PHARM3000
- PHARM3300
- EMED3995
Publications
Awards and Achievements
- Integrative Vascular Physiology and Pathology (IVPP) Study Section, National Institutes of Health
- Editorial Board, Annals of Emergency Medicine
- Science Policy Committee, FASEB
Bio
Kalev Freeman is a physician scientist whose research aims to improve outcomes for victims of trauma. Dr. Freeman leads an NIH-funded research program focused on one of the most urgent challenges in trauma surgery: the acute endotheliopathy that underlies multiorgan failure in critical illness and shock. Seminal work from his laboratory showed that circulating factors activate endothelial cells to drive thrombo-inflammation and microvascular dysfunction in severe trauma. His team also provided pivotal early-stage evidence that led to the development of modern diagnostic tools and resuscitation protocols for trauma-induced coagulopathy.
Courses
- PHARM3000
- PHARM3300
- EMED3995
Publications
Awards and Achievements
- Integrative Vascular Physiology and Pathology (IVPP) Study Section, National Institutes of Health
- Editorial Board, Annals of Emergency Medicine
- Science Policy Committee, FASEB
Select Publications
- Collier DM, Villalba N, Sackheim A, Bonev AD, Miller ZD, Moore JS, Shui B, Lee JC, Lee FK, Reining S, Kotlikoff MI, Nelson MT, Freeman K. Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1309-H1322. PubMed Central PMCID: PMC6620684.
- Mughal A, Sackheim AM, Sancho M, Longden TA, Russell S, Lockette W, Nelson MT, Freeman K. Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury. J Cereb Blood Flow Metab. 2021 Jun;41(6):1313-1327. PubMed Central PMCID: PMC8142130.
- Sackheim AM, Villalba N, Sancho M, Harraz OF, Bonev AD, D'Alessandro A, Nemkov T, Nelson MT, Freeman K. Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels. Function (Oxf). 2021;2(3) PubMed Central PMCID: PMC8462507.
- Villalba N, Sackheim AM, Lawson MA, Haines L, Chen YL, Sonkusare SK, Ma YT, Li J, Majumdar D, Bouchard BA, Boyson JE, Poynter ME, Nelson MT, Freeman K. The Polyanionic Drug Suramin Neutralizes Histones and Prevents Endotheliopathy. J Immunol. 2023 Aug 15;211(4):648-657. PubMed Central PMCID: PMC10644384.
- Bonson G, Lambert AR, Sackheim AM, Howard AJ, Piffard SH, Lescieur-Garcia C, Cleary J, Rubinelli L, Di Lorenzo A, Majumdar D, Hennig GW, Nelson MT, Freeman K. Endothelial-Specific Knockout of the Scramblase TMEM16F Impairs In Vivo Clot Formation. Shock. 2025 May 1;63(5):788-795. PubMed PMID: 39874534; NIHMSID: NIHMS2123384.
Professional Societies and Memberships
- American Board of Emergency Medicine (ABEM)
- Fellow of the American College of Emergency Physicians (FACEP)