University of Vermont

The College of Arts and Sciences

Department of Psychological Science

Sayamwong (Jom) Hammack

Biobehavioral Psychology

Sayamwong (Jom) Hammack

Sayamwong (Jom) Hammack
Professor

Education
  • B.S. Florida State University, 1995
  • M.A. University of Colorado, 1998
  • Ph.D. University of Colorado, 2001
  • C.V. (PDF)
Email: sayamwong.hammack@uvm.edu
Phone: (802) 656-1041
Room: 336
Website: Hammack Laboratory of Behavioral Neuroscience

Directorships
Director, Undergraduate Neuroscience Program

Areas
My research interests involve understanding the neurobiological mechanisms of stress, emotion and resilience. I use a variety of techniques to investigate these mechanisms, which include assessing conditioned and unconditioned fear and anxiety, pharmacological manipulations, neuroanatomical techniques, molecular, and intracellular electrophysiological techniques. I am particularly interested in the involvement of serotonin and stress-related neuropeptides in mediating the behavioral consequences of exposure to stressful stimuli, as well as the neurochemical changes mediating stress-resilience (for example, why does exercise reduce anxiety and make you more resilient in the face of stressors). Specific questions include:

  • What is the role of the bed nucleus of the stria terminalis (BNST) in mediating fear/anxiety behaviors, and how does it accomplish this role?
  • How do brain areas that mediate fear/anxiety behaviors (such as the BNST) respond to serotonin, and is the response to serotonin altered by inescapable stress, chronic stress, or exercise?
  • What are the roles of pituitary adenylate cyclase-activating polypeptide (PACAP) and corticotropin-releasing hormone (CRH) in mediating the behavioral and physiological consequences of stressor exposure?
  • How does exercise alter brain circuits that mediate fear/anxiety behaviors?

Representative Publications

  • Miles, O.W., Thrailkill, E.A., Linden, A.K., May, V., Bouton, M.E., Hammack, S.E. (2017) Pituitary adenylate cyclase-activating peptide in the bed nucleus of the stria terminalis mediates stress-induced reinstatement of cocaine seeking in rats, Neuropsychopharmacology, in press. PMID: 28656976
  • King, S.B., Lezak, K.R., O’Reilly, M., Toufexis, D.J., Falls, W.A., Braas, K.M., May, V., Hammack, S.E. (2017) The Effects of Prior Stress on Anxiety-like Responding to Intra-BNST Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) in Male and Female Rats, Neuropsychopharmacology, 42(8): 1679-1687. PMID: 28106040
  • King, S. B., Toufexis, D.J., Hammack, S.E. (2017) Pituitary adenylate cyclase activating polypeptide (PACAP), stress and sex hormones, Stress, in press. PMID: 28610473
  • Missig, G., Mei, L., Vizzard, M.A., Braas, K.M., Waschek, J.A., Hammack, S.E., May, V. (2016) Parabrachial PACAP activation of amygdala endosomal ERK signaling regulates the emotional component of pain, Biological Psychiatry, 81(8): 671-682. PMID: 28057459
  • Hammack, S.E., Todd, T.P., Kocho-Schellenberg, M., Bouton, M.E. (2015) Role of the bed nucleus of the stria terminalis in the acquisition of contextual fear at long or short context-shock intervals, Behavioral Neuroscience, 129(5): 673-8. PMID: 26348716.
  • Hammack, S.E., May, V. (2015) Pituitary adenylate cyclase activating polypeptide in stress-related disorders: data convergence from animal and human studies, Biological Psychiatry, 78(3): 167-77. PMID: 25636177.

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