Yvonne Janssen-Heininger
University Distinguished Professor of Pathology and Laboratory Medicine
Vice Chair for Research
Co-Leader Cancer Cell Research Program, UVM Cancer Center
149 Beaumont Avenue
HSRF 216A
Burlington, VT 05405
United States
- Postdoctoral Associate, University of Vermont, Department of Pathology, Burlington, VT
- Ph.D., Maastricht University, The Netherlands
- B.A./M.S., University of Limburg, Maastricht, The Netherlands
Department of Pathology and Laboratory Medicine
University of Vermont Cancer Center
Cellular, Molecular, and Biomedical Sciences Program
Areas of expertise
Epithelial Cell and Redox Biology
BIO
I am Professor and Vice-Chair for Research and Co-Leader Cancer Cell Research Program, University of Vermont Cancer Center. In this capacity, I organize and lead research efforts in the Department of Laboratory of Medicine. With the unique resources available in our department, we deploy the best possible models of human disease consisting of well annotated tissue micro-arrays, patient-derived organoids and precision cut tissue slices. I foster a research environment wherein trainees, Faculty and staff all work together to advance our research programs to improve diagnostics and knowledge about disease processes with the overarching goal to develop new treatments for chronic diseases.
I have received numerous honors and awards, including the UVM distinguished Professor and University Scholar recognition and Fellow of the Society for Redox Biology and Pathology. I have a number of (inter)national administrative leadership roles exemplified by my role as Member of the Heart Lung and Blood Program Project Review Committee that I Chaired in 2022-2023, the former Chair of the Lung Injury Repair and Remodeling Study Section, the 2020 Gordon Research Conference on Oxygen Radicals. Citations: >19,000, h-Index 75, i-10 Index 170 (Some manuscripts were published under my maiden name Janssen) ORCID ID: 0000-0002-2735-87.
- I run an NIH-funded laboratory centered on lung fibrosis and lung cancer and the intersection between these two diseases. Research aims to understand alterations is stem cell plasticity and the processes that regulate how stem cells behave.
- Our research is focused on stem cell metabolism. Changes in oxygen metabolism (redox) are drivers of cell plasticity changes. We measure these events with nanoscale precision to understand how proteins function differently when oxidized.
- An overarching goal is to design thiol-based drugs to normalize proteins, or to target enzymes that control protein oxidations and to correct these to combat lung fibrosis and lung cancer.
Publications
Dr. Janssen-Heininger's publications on PubMed
Awards and Achievements
University of Vermont Distinguished Professor
Bio
I am Professor and Vice-Chair for Research and Co-Leader Cancer Cell Research Program, University of Vermont Cancer Center. In this capacity, I organize and lead research efforts in the Department of Laboratory of Medicine. With the unique resources available in our department, we deploy the best possible models of human disease consisting of well annotated tissue micro-arrays, patient-derived organoids and precision cut tissue slices. I foster a research environment wherein trainees, Faculty and staff all work together to advance our research programs to improve diagnostics and knowledge about disease processes with the overarching goal to develop new treatments for chronic diseases.
I have received numerous honors and awards, including the UVM distinguished Professor and University Scholar recognition and Fellow of the Society for Redox Biology and Pathology. I have a number of (inter)national administrative leadership roles exemplified by my role as Member of the Heart Lung and Blood Program Project Review Committee that I Chaired in 2022-2023, the former Chair of the Lung Injury Repair and Remodeling Study Section, the 2020 Gordon Research Conference on Oxygen Radicals. Citations: >19,000, h-Index 75, i-10 Index 170 (Some manuscripts were published under my maiden name Janssen) ORCID ID: 0000-0002-2735-87.
- I run an NIH-funded laboratory centered on lung fibrosis and lung cancer and the intersection between these two diseases. Research aims to understand alterations is stem cell plasticity and the processes that regulate how stem cells behave.
- Our research is focused on stem cell metabolism. Changes in oxygen metabolism (redox) are drivers of cell plasticity changes. We measure these events with nanoscale precision to understand how proteins function differently when oxidized.
- An overarching goal is to design thiol-based drugs to normalize proteins, or to target enzymes that control protein oxidations and to correct these to combat lung fibrosis and lung cancer.
Publications
Awards and Achievements
University of Vermont Distinguished Professor