304 Stafford Hall
95 Carrigan Drive
Burlington, VT 05405
United States
- Ph.D., Microbiology, Université Pierre & Marie Curie, Paris 6, France
- BSc, Molecular Genetics, Université Paris 11, France
- Fellowship, University of British Columbia, Vancouver, BC, Canada
Department of Microbiology and Molecular Genetics
Areas of expertise
cell biology, bacterial infections, bacterial pathogenesis, Type IV secretion systems and effectors, autophagy.
BIO
Jean Celli is a Professor of Microbiology in the Larner College of Medicine. His work centers on understanding the cellular and molecular mechanisms of intracellular survival and proliferation of zoonotic bacterial pathogens. Using Brucella abortus, the causative agent of the worldwide disease brucellosis, as model pathogen, Dr Celli's research focuses on understanding how bacteria remodel host transport and autophagic functions during infections, via delivery of effector proteins to promote bacterial survival, proliferation and egress. His teaching draws from this research, including courses on host-microbe interactions.
- Received his Ph.D. in Microbiology, Université Pierre & Marie Curie, Paris 6, France (1997), studying genetic mobile elements that transfer antibiotic resistance among pathogenic bacteria.
- Trained as a Postdoctoral Fellow at the University of British Columbia, Vancouver, Canada (1998-2001), focusing on how the food-borne pathogen Enteropathogenic Escherichia coli (EPEC) disarms immune phagocytes.
- Held an INSERM CR2 Research Scientist position (2001-2004) at the Centre d’Immunologie de Marseille-Luminy, France, where his research focused on characterizing the intracellular cycle of the Brucellosis-causing bacterium Brucella abortus.
- Held an NIH Investigator position at the NIH Rocky Mountain Laboratories, NIAID from 2004 to 2013, where he further developed cellular and molecular studies of bacterial pathogen interactions with phagocytes.
- Became faculty at the Paul G. Allen School for Global Health at Washington State University as Associate Professor then Professor between 2013 and 2022 to continue research on the cell biology of zoonotic bacterial infections.
- Joined UVM Department of Microbiology and Molecular Genetics in 2023 as Professor.
Courses
- MMG6110 - Advanced Bacterial Genetics
- MMG6990A - Host-Microbe Interactions
Publications
Bio
Jean Celli is a Professor of Microbiology in the Larner College of Medicine. His work centers on understanding the cellular and molecular mechanisms of intracellular survival and proliferation of zoonotic bacterial pathogens. Using Brucella abortus, the causative agent of the worldwide disease brucellosis, as model pathogen, Dr Celli's research focuses on understanding how bacteria remodel host transport and autophagic functions during infections, via delivery of effector proteins to promote bacterial survival, proliferation and egress. His teaching draws from this research, including courses on host-microbe interactions.
- Received his Ph.D. in Microbiology, Université Pierre & Marie Curie, Paris 6, France (1997), studying genetic mobile elements that transfer antibiotic resistance among pathogenic bacteria.
- Trained as a Postdoctoral Fellow at the University of British Columbia, Vancouver, Canada (1998-2001), focusing on how the food-borne pathogen Enteropathogenic Escherichia coli (EPEC) disarms immune phagocytes.
- Held an INSERM CR2 Research Scientist position (2001-2004) at the Centre d’Immunologie de Marseille-Luminy, France, where his research focused on characterizing the intracellular cycle of the Brucellosis-causing bacterium Brucella abortus.
- Held an NIH Investigator position at the NIH Rocky Mountain Laboratories, NIAID from 2004 to 2013, where he further developed cellular and molecular studies of bacterial pathogen interactions with phagocytes.
- Became faculty at the Paul G. Allen School for Global Health at Washington State University as Associate Professor then Professor between 2013 and 2022 to continue research on the cell biology of zoonotic bacterial infections.
- Joined UVM Department of Microbiology and Molecular Genetics in 2023 as Professor.
Courses
- MMG6110 - Advanced Bacterial Genetics
- MMG6990A - Host-Microbe Interactions
Publications
Select Publications
- Borghesan E, Smith EP, Myeni S, Binder K, Knodler LA, Celli J (2021) A Brucella effector modulates the Arf6-Rab8a GTPase cascade to promote intravacuolar replication. EMBO J e107664, doi: 10.15252/embj.2021107664 PMID: 34423453.
- Miller CN, Smith EP, Cundiff JA, Knodler LA, Bailey Blackburn J, Lupashin, V, Celli J. (2017) A Brucella Type IV effector targets the COG tethering complex to remodel host secretory traffic and promote intracellular replication. Cell Host Microbe. 22:317-329, doi:10.1016/j.chom.2017.07.017.
- Starr T, Child R, Wehrly TD, Hansen B, Hwang, S, C. Lòpez-Otin, Virgin HW and Celli J (2012) Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. Cell Host Microbe, 11(1): 33-45 • C. Checroun, T. D Wehrly, E. R. Fisher, S. F. Hayes and J. Celli. (2006) Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment following cytoplasmic replication. Proc. Natl Acad. Sci. USA, 103(39): 14578-14583.
- J. Celli, C. de Chastellier, D.-M. Franchini, J. Pizarro-Cerda, E. Moreno and J.P. Gorvel. (2003) Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum. J. Exp. Med., 198:545-556.
Lab Team
Pedro Francisco Soler Llorens, PhD - Post-doctoral Associate
Punsiri Mahendra Colonne, PhD - Post-doctoral Associate