Christopher Francklyn
Professor, Biochemistry
Adjunct Professor, Microbiology and Molecular Genetics
Director, Vermont Biomedical Research Network
Larner College of Medicine
Department of Biochemistry
Given B401
Burlington, VT 05405
United States
- Postdoctoral Studies, Massachusetts Institute of Technology, Cambridge, MA, 1989-1991
- Ph.D., University of California at Santa Barbara, 1988
- M.A., University of California at Santa Barbara, 1983
- B.S., University of California at Santa Barbara, 1979
Areas of expertise
Protein Synthesis
Nucleic Acids
Genetics of Inherited Neurological Diseases
BIO
Christopher Francklyn is a Professor of Biochemistry and Director of UVM’s Vermont Biomedical Research Network, our P20 NIGMS INBRE program. His work employs biochemistry, structural biology, and data methods to characterize the cellular machinery that interprets the genetic code in all domains of life. He is particularly interested in how mutations in the genes that encode these components lead to inherited neurological diseases. This work is important for understanding how people with these genetic markers exhibit a range of neurological conditions that affect the peripheral and central nervous systems. In addition to research in these areas, Dr. Francklyn is a long-time instructor in all areas of biochemistry for undergraduates, graduate students, and medical students at UVM. Earlier, he worked with others to create UVM’s Undergraduate Program in Biochemistry.
Publications
Awards and Achievements
- 2020 Fellow of the American Association for the Advancement of Science (AAAS), the world’s largest multidisciplinary scientific society, for outstanding contributions to science
- 2020 Vermont Academy of Science and Engineering, Inductee
- 2019 "Progress and Challenges in Aminoacyl-tRNA Synthetase-based Therapeutics., The Journal of Biological Chemistry, 2019, was recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member John Lowe
- 2017 Principal Organizer, AARS 2017, Clearwater, Florida, November
- 2016 Editorial Board, Nature Scientific Reports 2016-2017
- 2012 US Patent Application # US10175237B2. Granted: 1/09/2019. "Methods and Compounds for Diagnosing Threonyl-tRNA Synthetase-Associated Diseases and Conditions. Priority Date: 2012-07-25 Inventors: Christopher Francklyn, Karen Lounsbury, and Tamara Williams 2012-2018
- 2012 US Patent # US10125358B2. Granted: 11/13/2018. "Methods and Compounds for IncreasingThreonyl-tRNA Synthetase Activity." Priority Date: 2012-07-25. Inventors: Christopher Francklyn, Karen Lounsbury, and Jason Botton. 2012-2018
- 2011 Editorial Board, Principal Investigators.org
- 2008 NIH Special Emphasis Panel, F31 Fellowships for Minority Graduate Students.
- 2006 Editorial Board, Journal of Biological Chemistry 2006-2011
- 2004 Chair, Molecular Genetics A Study Section, NIH 2004-2006
- 1999 Standing Member, NIH Biochemistry Study Section, 1999, 2002-2004
- 1999 Ad hoc member, Biochemistry Section, NIH, 1999, 2002
- 1998 Panelist, NSF International Postdoctoral Award Committee, Who's Who in America 1998-2002
- 1998 Session Chair, EMBO Symposium, Aminoacyl-tRNA Synthetases
- 1996 College of Medicine Faculty Development Award
- 1995 J. Walter Juckett Scholar Award
- 1988 National Institutes of Health National Research Service Award
- 1985 Regent's Fellowship, University of California, Santa Barbara 1985-1986
Bio
Christopher Francklyn is a Professor of Biochemistry and Director of UVM’s Vermont Biomedical Research Network, our P20 NIGMS INBRE program. His work employs biochemistry, structural biology, and data methods to characterize the cellular machinery that interprets the genetic code in all domains of life. He is particularly interested in how mutations in the genes that encode these components lead to inherited neurological diseases. This work is important for understanding how people with these genetic markers exhibit a range of neurological conditions that affect the peripheral and central nervous systems. In addition to research in these areas, Dr. Francklyn is a long-time instructor in all areas of biochemistry for undergraduates, graduate students, and medical students at UVM. Earlier, he worked with others to create UVM’s Undergraduate Program in Biochemistry.
Publications
Awards and Achievements
- 2020 Fellow of the American Association for the Advancement of Science (AAAS), the world’s largest multidisciplinary scientific society, for outstanding contributions to science
- 2020 Vermont Academy of Science and Engineering, Inductee
- 2019 "Progress and Challenges in Aminoacyl-tRNA Synthetase-based Therapeutics., The Journal of Biological Chemistry, 2019, was recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member John Lowe
- 2017 Principal Organizer, AARS 2017, Clearwater, Florida, November
- 2016 Editorial Board, Nature Scientific Reports 2016-2017
- 2012 US Patent Application # US10175237B2. Granted: 1/09/2019. "Methods and Compounds for Diagnosing Threonyl-tRNA Synthetase-Associated Diseases and Conditions. Priority Date: 2012-07-25 Inventors: Christopher Francklyn, Karen Lounsbury, and Tamara Williams 2012-2018
- 2012 US Patent # US10125358B2. Granted: 11/13/2018. "Methods and Compounds for IncreasingThreonyl-tRNA Synthetase Activity." Priority Date: 2012-07-25. Inventors: Christopher Francklyn, Karen Lounsbury, and Jason Botton. 2012-2018
- 2011 Editorial Board, Principal Investigators.org
- 2008 NIH Special Emphasis Panel, F31 Fellowships for Minority Graduate Students.
- 2006 Editorial Board, Journal of Biological Chemistry 2006-2011
- 2004 Chair, Molecular Genetics A Study Section, NIH 2004-2006
- 1999 Standing Member, NIH Biochemistry Study Section, 1999, 2002-2004
- 1999 Ad hoc member, Biochemistry Section, NIH, 1999, 2002
- 1998 Panelist, NSF International Postdoctoral Award Committee, Who's Who in America 1998-2002
- 1998 Session Chair, EMBO Symposium, Aminoacyl-tRNA Synthetases
- 1996 College of Medicine Faculty Development Award
- 1995 J. Walter Juckett Scholar Award
- 1988 National Institutes of Health National Research Service Award
- 1985 Regent's Fellowship, University of California, Santa Barbara 1985-1986