Checking out films in the lab

A unique aspect of the CMB Program is the interdisciplinary nature of the individual research projects, which are often highly collaborative and cross traditional department boundaries. A number of participating faculty have primary appointments in clinical as well as basic science departments, bringing a broad perspective of contemporary problems in cell, molecular and biomedical sciences.

The research enterprise in the CMB Program is well-funded by extramural support in the form of individual research awards, program projects grants, and pre- and post-doctoral training grants. Funding sources include the National Institutes of Health, National Science Foundation, American Heart Association, USDA and NASA. Large interdisciplinary, multi-investigator grants fund research projects in cancer biology, cardiovascular biology and cell motility, environmental pathology, immunobiology, neuroscience, and pulmonary function and disease.

In addition, students have access to cutting-edge equipment and focused training in our core facilities. These facilities include the Bioinformatics, X-Ray Crystallography, DNA Analysis, Flow Cytometry, Microscopy and Imaging, and Transgenic Mice cores.

Note: Faculty listed below have self identified their participation in these areas, and may be listed in multiple categories. For an alphabetical list of faculty, please visit the faculty directory.

Faculty Research Listed by Topic Area

 

Cancer Biology and Genome Stability
Name Areas of Expertise and/or Research
Ralph Budd Death receptor regulation of apoptosis in the immune system
Frances Carr Cellular events which mediate thyroid hormone action in development and pathophysiology
Paula Deming Molecular Signaling Mechanisms, Growth Control Pathways, Cancer Biology
Sylvie Doublie X-Ray Crystallography
Barry Finette Mutagenic Mechanisms in Pediatric Diseases
Christopher Francklyn Protein Synthesis in Biological Regulation and Human Disease
Seth Frietze Molecular Biology, Genomics, Cancer Biology
Karen Glass Structure and function of epigenetic reader domains
Jessica Heath Pediatric Leukemias: epigenetics, mechanisms of leukemogenesis, and novel treatment development
Robert Hondal Mechanism of Thioredoxin Reductase — a Collaborative Project
Alan Howe Regulation of cell migration by extracellular matrix
Robert Kelm Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Christopher Landry Materials Chemistry, Nanotechnology, and Particles in Biology
Jane Lian Bone biology and pathogenesis
Karen Lounsbury Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis
Scott Morrical DNA Repair- structure and function of protein-DNA complexes
David Pederson DNA Replication and Repair in Chromatin
Delphine Quenet PARP Biology and Chromatin
Mercedes Rincon Signaling and gene regulation in thymus development, activation, differentiation and death of CD4+ and CD8+ T cells
Arti Shukla Understanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies
Girja Shukla Cancer-specific affinity molecules for diagnosis and targeted therapy
Gary Stein Cancer, Stem Cell and Bone Biology Program
Janet Stein Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason Stumpff Molecular Control of Cell Division
Michael Toth Translational studies of human skeletal muscle structure and function
Susan Wallace DNA Damage and Repair
Kaleem Zaidi

Epigenetic Mechanisms of Leukemogenesis

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Genomics and Computational Biology
Name Areas of Expertise and/or Research
Sylvie Doublie X-Ray Crystallography
Seth Frietze Molecular Biology, Genomics, Cancer Biology
Karen Glass Structure and function of epigenetic reader domains
Jonathan Gordon Epigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions
Dawei Li Human Genetics and Genomics
Jane Lian Bone biology and pathogenesis
Michael Radermacher Structure determination and functional studies of macromolecular assemblies using 3DEM
Teresa Ruiz Structural and Functional Studies of Macromolecular Complexes
Gary Stein Cancer, Stem Cell and Bone Biology Program
Janet Stein Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Kaleem Zaidi Epigenetic Mechanisms of Leukemogenesis

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Immunology and Microbial Pathogenesis
Name Areas of Expertise and/or Research
Eyal Amiel Metabolic Regulation of Dendritic Cell Activation and Immune Function
John Barlow Mathematical and molecular epidemiology of infectious disease; Host-Pathogen interactions in mastitis; Cattle MHC
Elizabeth Bonney Maternal immunity and tolerance
Jason Botten Host immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines
Jonathan Boyson The regulation and function of innate-like T cells
Ralph Budd Death receptor regulation of apoptosis in the immune system
Iwona Buskiewicz Innate immune responses to viral infection in heart; Role of innate immune responses to viral infection in development of autoimmunity
Sean Diehl Vaccines and immunology
Seth Frietze Molecular Biology, Genomics, Cancer Biology
Christopher Huston Host-Pathogen Interactions of Intestinal Protozoa
Charlie (Charles) Irvin Asthma Pathogenesis, respiratory physiology and airway biology
Douglas Johnson Yeast Biofilm Formation and Virulence
David Kerr Innate Immunity to Dairy Mastitis
Keith Mintz Molecular Mechanisms of Bacterial Pathogenesis
Dimitry Krementsov Autoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome
Matthew Poynter Airway epithelium in innate and adaptive immune responses
Mercedes Rincon Signaling and gene regulation in thymus development, activation, differentiation and death of CD4+ and CD8+ T cells
Teresa Ruiz Structural and Functional Studies of Macromolecular Complexes
Girja Shukla Cancer-specific affinity molecules for diagnosis and targeted therapy
Benjamin Suratt Host factors and their effects on innate immunity and lung inflammation and injury
Cory Teuscher Genetics of susceptibility to infectious and autoimmune disease
Markus Thali Multiscale analyses of HIV-1 cell-to-cell transmission
Gary Ward Cell Biology of Host-Parasite Interaction
Matthew Wargo Regulation of Bacterial Virulence and Catabolism
Daniel Weiss Gene and stem cell therapies for lung diseases

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Lung and Cardiovascular Biology
Name Areas of Expertise and/or Research
Vikas Anathy Endoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases
Beth Bouchard Mechanisms regulating factor V endocytosis by megakaryocytes
Joe Brayden Pharmacology: Ionic mechanisms of vasoconstriction and vasodilation in cerebral arterioles
Frances Carr Cellular events which mediate thyroid hormone action in development and pathophysiology
Marilyn Cipolla Cerebral circulation under physiological and pathological conditions
Wolfgang Dostmann cGMP/PKG signaling in vascular smooth muscle; Pharmacology
Benedek Erdos Neural control of cardiovascular function; stress, obesity and aging
Stephen Everse Structure & Function of Proteins
Kalev Freeman Trauma physiology/ traumatic brain injury
Charlie (Charles) Irvin Asthma Pathogenesis, respiratory physiology and airway biology.
Yvonne Janssen-Heininger Transcriptional regulators of lung responses to injury and inflammation
Robert Kelm Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Karen Lounsbury Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis
Mark Nelson Pharmacology – Understanding the control of smooth muscle and endothelial cell function by ion channels and calcium signaling.
Matthew Poynter Airway epithelium in innate and adaptive immune responses
Michael Radermacher Structure determination and functional studies of macromolecular assemblies using 3DEM
Mercedes Rincon Signaling and gene regulation in thymus development, activation, differentiation and death of CD4+ and CD8+ T cells
Teresa Ruiz Structural and Functional Studies of Macromolecular Complexes
Arti Shukla Understanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies
Jay Silveira Biochemistry of Platelet Function
Jeff Spees Adult Stem Cell Biology and Regenerative Medicine
Benjamin Suratt Host factors and their effects on innate immunity and lung inflammation and injury
Doug Taatjes Cell imaging and disease
Cory Teuscher Genetics of susceptibility to infectious and autoimmune disease
Michael Toth Translational studies of human skeletal muscle structure and function
Paula Tracy Biochemistry of Platelet Function
Russell Tracy Thrombosis and cardiovascular disease
Kathleen Trybus Molecular motors and their tracks
Albert van der Vliet Biological and environmental oxidants and airway inflammation: Mechanisms of redox signaling
Jim Vigoreaux Biology of insect flight muscle and vertebrate cardiac muscle
Matthew Wargo Regulation of Bacterial Virulence and Catabolism
David Warshaw Myosin Molecular Motors
Daniel Weiss Gene and stem cell therapies for lung diseases
George Wellman Cerebral artery function in health and disease

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Molecular Cell Biology and Genetics
Name Areas of Expertise and/or Research
Vikas Anathy Endoplasmic Reticulum (ER) Based Chaperones and Protein Disulfide Isomerases in Lung Diseases
Jason Botten Host immune response to viral infection, the basis of persistent viral infection in reservoir hosts, host-pathogen interactions, and the development of novel therapeutic agents and vaccines
Ralph Budd Death receptor regulation of apoptosis in the immune system
Wolfgang Dostmann cGMP/PKG signaling in vascular smooth muscle; Pharmacology
Benedek Erdos Neural control of cardiovascular function; stress, obesity and aging
Barry Finette Mutagenic Mechanisms in Pediatric Diseases
Jeanne Harris Developmental Genetics of Legume Root Nodules
Alan Howe Regulation of cell migration by extracellular matrix
Yvonne Janssen-Heininger Transcriptional regulators of lung responses to injury and inflammation
Thomas Jetton Mechanisms that regulate the development, growth, and regeneration of pancreatic beta cells
Doug Johnson Yeast Biofilm Formation and Virulence
Robert Kelm Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Dimitry Krementsov Autoimmunity, sex differences, neuroimmunology, multiple sclerosis, gene-by-environment interactions, microbiome
Jane Lian Bone biology and pathogenesis
Karen Lounsbury Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis
Anthony Morielli Molecular mechanisms of ion channel regulation in the brain
Jill Preston Evolutionary genetics of plant development
Delphine Quenet PARP biology and chromatin
Mercedes Rincon Signaling and gene regulation in thymus development, activation, differentiation and death of CD4+ and CD8+ T cells
Arti Shukla Understanding Pathogenesis of mesothelioma and identifying appropriate thearapeutic strategies
Jeff Spees Adult Stem Cell Biology and Regenerative Medicine
Gary Stein Cancer, Stem Cell and Bone Biology Program
Janet Stein Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason Stumpff Molecular Control of Cell Division
Doug Taatjes Cell imaging and disease
Markus Thali Multiscale analyses of HIV-1 cell-to-cell transmission
Mary Tierney Mechanisms for controlling cell function through ECM structure
Michael Toth Translational studies of human skeletal muscle structure and function
Albert van der Vliet Biological and environmental oxidants and airway inflammation: Mechanisms of redox signaling
Judy Van Houten Chemical signal transduction
Jim Vigoreaux Biology of insect flight muscle and vertebrate cardiac muscle
Susan Wallace DNA Damage and Repair
Gary Ward Cell Biology of Host-Parasite Interaction
Matthew Wargo Regulation of Bacterial Virulence and Catabolism

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Stem Cell And Developmental Biology
Name Areas of Expertise and/or Research
Elizabeth Bonney Maternal immunity and tolerance
Jonathan Gordon Epigenetics and Gene Regulation, Bone biology, Mesenchymal Stromal Cells, Bone and cancer interactions
Jeanne Harris Developmental Genetics of Legume Root Nodules
Thomas Jetton Mechanisms that regulate the development, growth, and regeneration of pancreatic beta cells
Jane Lian Bone biology and pathogenesis
Jill Preston Evolutionary genetics of plant development
Jeff Spees Adult Stem Cell Biology and Regenerative Medicine
Gary Stein Cancer, Stem Cell and Bone Biology Program
Janet Stein Regulation of Gene Expression during the Cell Cycle and during the Proliferation/Differentiation Transition
Jason Stumpff Molecular Control of Cell Division
Mary Tierney Mechanisms for controlling cell function through ECM structure
Daniel Weiss Gene and stem cell therapies for lung diseases.
Kaleem Zaidi Epigenetic Mechanisms of Leukemogenesis

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Structural Biology and Biophysics
Name Areas of Expertise and/or Research
Christopher Berger Molecular Mechanisms of Axonal Transport
Wolfgang Dostmann cGMP/PKG signaling in vascular smooth muscle; Pharmacology
Sylvie Doublie X-Ray Crystallography
Stephen Everse Structure & Function of Proteins
Christopher Francklyn Structure and Function of Nucleic Acid Binding Proteins
Karen Glass Structure and function of epigenetic reader domains
Robert Hondal Mechanism of Thioredoxin Reductase — a Collaborative Project
Robert Kelm Regulation of Cell Differentiation by ssDNA/RNA-Binding Proteins
Jianing Li Multiscale modeling of biological macromolecules
Dwight Matthews Analytical and clinical applications of mass spectrometry
Scott Morrical DNA Repair- structure and function of protein-DNA complexes
David Pederson DNA Replication and Repair in Chromatin
Michael Radermacher Structure determination and functional studies of macromolecular assemblies using 3DEM
Teresa Ruiz Structural and Functional Studies of Macromolecular Complexes
Gary Stein Cancer, Stem Cell and Bone Biology Program
Jason Stumpff Molecular Control of Cell Division
Kathleen Trybus Molecular motors and their tracks
Judy Van Houten Cilia structure and function
Susan Wallace DNA Damage and Repair
David Warshaw Myosin Molecular Motors

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