Sean Diehl
Associate Professor
Department of Microbiology and Molecular Genetics
Larner College of Medicine
BIO
The immune system protects us from infectious agents, but when functioning improperly, can also cause disease. My research is aimed at determining the molecular mechanisms occurring in immune cells that control these responses. We study the cellular response to infection, but also seek to understand about the intracellular response of immune cells in the context of inflammatory diseases such as allergic asthma. To address these questions, our lab utilizes in vitro culture of primary human cells, flow cytometry, mRNA analysis, immunostaining, as well as stable in vitro genetic modification of primary human lymphocytes derived from both control and patient populations.
Area(s) of expertise
Molecular biology techniques, Immunological assays (in vitro, ex vivo, and in vivo)
Bio
The immune system protects us from infectious agents, but when functioning improperly, can also cause disease. My research is aimed at determining the molecular mechanisms occurring in immune cells that control these responses. We study the cellular response to infection, but also seek to understand about the intracellular response of immune cells in the context of inflammatory diseases such as allergic asthma. To address these questions, our lab utilizes in vitro culture of primary human cells, flow cytometry, mRNA analysis, immunostaining, as well as stable in vitro genetic modification of primary human lymphocytes derived from both control and patient populations.
Areas of Expertise
Molecular biology techniques, Immunological assays (in vitro, ex vivo, and in vivo)