Associate Professor

Dr. Rachael Floreani's research program revolves around sustainable biopolymer material design and fabrication for tissue engineering, regenerative medicine applications, sustainable industrial plastic-alternatives, and cultivated meat scaffolds. The Engineered Biomaterials Research Laboratory, under Dr. Floreani's direction, investigates the fundamental understanding and development of polymeric materials for specific interactions with the human body or the environment. Areas of interest include: (i) developing novel polymeric materials and precursors; (ii) utilizing processing techniques to fabricate scaffolds with the desired micro-/macroscopic structures both spatially and temporally; (iii) investigating the interaction of biology with materials-based techniques to control cell behavior; and (iv) using polymers to control the delivery of bioactive molecules.

Publications

  1. Patrick Charron, Irfan Tahir, Sierra McConnell, Danielle Sedler, Rachael A. Floreani. Physico-Mechanical and Ex Vivo Analysis of Aloe-Alginate Hydrogels for Cervical Cancer Treatment. In review.
  2. Patrick Charron, Luis Garcia, Irfan Tahir, Rachael A. Floreani. HUVEC Tubular Formation on Bio-Inspired Vascularization Substrates. Journal of the Mechanical Behavior of Biomedical Materials, 2021, in print.
  3. Patrick Charron, Jaime Jacobs, Selina Yao, Rachael Oldinski. Effects of Cryo-processing on the Mechanical and Biological Properties of PVA-Gelatin Theta-Gels. Biointerphases, 15(5), 051004, 2020.
  4. Tianxin Miao, Alexander Aronshtam, Andrew Little, Spencer L. Fenn, Milena Hristova, Dimitry N. Krementsov, Albert van der Vliet, Jeffrey Spees, Rachael A. Oldinski. Internalized FGF-2-loaded nanoparticles increase nuclear ERK1/2 content and result in lung cancer cell death. Nanomaterials, 10(4), 612, 2020. *Invited article, special edition
  5. Esmat Jalalvandi, Patrick Charron, Rachael A. Oldinski. Physico-mechanical characterization of liquid versus solid applications of visible light crosslinked tissue sealants. ACS Applied Bio Materials, 2(3), 1204-1212, 2019.
  6. Patrick N. Charron, Tess Braddish, Rachael A. Oldinski. PVA-gelatin hydrogels formed using combined theta-gel and cryo-gel fabrication techniques. Journal of the Mechanical Behavior of Biomedical Materials, v.92: 90-96, 2019.

Areas of Expertise and/or Research

Biomedical and Plant Derived Materials Engineering, Sustainable Polymers/Plastics, Tissue Engineering, Cellular Agriculture

Education

  • M.S. and Ph.D. Mechanical Engineering (Colorado State University)
  • B.S. Biomedical Engineering (Michigan Technological University)

Contact

Office Location:

201D Votey Hall

Office Hours:

By appointment

Website(s):
  1. Lab Website

Courses Taught

  • ME 14 Solid Mechanics
  • ME 101 Materials Science and Engineering
  • ME/BME 201 Biomaterials Science and Engineering
  • ME/BME 204 Biothermodynamics
  • ME/BME 207 Bioengineering
  • ME/BME 208 Biomechanics: Tissue Engineering