OMIM entry for TP53
"Vogelstein and Kinzler (1992) proposed a model in which
p53 binds as a tetramer to a p53-binding site (PBS) and activates the expression
of downstream genes that inhibit growth and/or invasion." - so breaking
this protein results in cells that are more likely to divide inappropriately.
"Cho et al. (1994) succeeded in co-crystallizing the core domain
of p53 bound to DNA. " The structure of a p53-DNA complex is known!
Find the reference entry by following the link to Cho et al. , find
the PubMed entry by following the "8023157" link.
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