"Li and Fraumeni (1969) identified 4 families in which sibs
or cousins had a childhood sarcoma. These 4 families also had striking histories
of breast cancer and other neoplasms, suggesting a new familial cancer syndrome
of diverse tumors."In reviewing medical records and death certificates of
648 childhood rhabdomyosarcoma patients, Li and Fraumeni (1969)" -
Li Fraumeni syndrome is a genetic disorder involving predisposition to cancer.
What causes Li Fraumeni syndrome?
"... mutations in the TP53 gene (191170) have been found in this disorder". Select
the "191170"
link to go to the OMIM TP53 page and learn more about TP53.