Development of Papillary Thyroid Cancer

• Multi-hit process (due to multiple mutations)

• First hit could be radiation

• Next mutation of genes

• Leads to changes in gene expression and uncontrollable growth of cells2

Fig. 2. Illustration, Genetic events in progression to thyroid papillary carcinomas. James A. Fagin, ed. Thyroid Cancer (Massachusetts: Kluwer, 1998) 74.

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