Dynamic Imaging of Joint Motion Using High-speed Dual Fluoroscopy
Imaging of Musculoskeletal Tissue Structure, Size and Composition
Joint Mechanics Estimation via Patient-Specific Computer Models
Improving musculoskeletal health through scientific investigations of structure and function
Dynamic Imaging of Joint Motion Using High-speed Dual Fluoroscopy
Imaging of Musculoskeletal Tissue Structure, Size and Composition
Joint Mechanics Estimation via Patient-Specific Computer Models
The overarching goal of the Musculoskeletal Imaging and Orthopaedic Biomechanics (MIOB) Laboratory is to improve human health and performance for those who suffer from musculoskeletal and orthopaedic conditions. Our approaches span experimental and computational methods. We use magnetic resonance imaging (MRI) to visualize disease and quantify anatomy, and we image bone motion directly with dynamic x-ray. Our computational studies combine patient-specific MR-based models with dynamic motion measurements to estimate internal tissue mechanics of orthopaedic tissues. Overall, the experimental and computational methods employed by the MIOB lab aim to improve health outcomes and reduce burdens imposed on patients and our healthcare system.
MIOB Lab 
Niccolo Fiorentino, PhD
Sadegh Khodabandeloo, M.S.
Divya Pradip Roy, B.S.
Natalie Bett, B.S.
Lincoln Lewisesquerre
Marit Scott, M.S., BME
Julianne Boughton, M.S., BME
Amanda Haddad, B.S., BME
John Ramsdell, Ph.D., BME
Eduardo Valdez, M.S., ME 
Haley Kuralt, M.S., BME
Emily Kastens, B.S., BME
Zephyr Paxton
Tori Weissman, B.S., BME 
Binyameen Ghafoor, B.S., BME 
Katlyn Hall, B.S., BME 
Kylie Willis, B.S., BME 
Emma Marston, B.S., BME 
James Doherty, B.S., BME Dr. Fiorentino chosen as inaugural Karl and Mary Fessenden Professor. Such an honor!
Way to go Marit and Natalie!
Haley and Sadegh successfully defend their theses in back-to-back defenses. Congratulations you two!!
Nice work, Dr. Johnny!
Johnny delivers a podium presentation and a poster presentation at the North American Congress on Biomechanics in Ottawa, Canada. Well done Johnny!
Select Publications from MIOB Lab Members
Ramsdell JC, Beynnon BD, Borah AS, Gardner-Morse MG, Zhang J, Krug MI, Tourville TW, Geeslin M, Failla MJ, DeSarno M, Fiorentino NM. Tibial and femoral articular cartilage exhibit opposite outcomes for T1ρ and T2* relaxation times in response to acute compressive loading in healthy knees. J Biomech. 2024 May;169:112133. doi: 10.1016/j.jbiomech.2024.112133. Epub 2024 May 4. PMID: 38744146
Knaus KR, Handsfield GG, Fiorentino NM, Hart JM, Meyer CH, Blemker SS. Athlete Muscular Phenotypes Identified and Compared with High-Dimensional Clustering of Lower Limb Muscle Volume Measurements. Med Sci Sports Exerc. 2023 Oct 1;55(10):1913-1922. doi: 10.1249/MSS.0000000000003224. Epub 2023 Jun 1. PMID: 37259254
Ramsdell JC, Beynnon BB, Borah A, Gardner-Morse MG, Zhang J, Krug M, Tourville T, Geeslin M, Failla M, Vacek PM, Fiorentino NM. T1ρ and T2* Measurements in Small and Knee-Sized Magnetic Resonance Imaging Phantoms: Effect of Phantom Size and Position Relative to Isocenter. Osteoarthritis Imaging. 2023 Jul 11. 3:100162. doi.org/10.1016/j.ostima.2023.100162.
Ramsdell JC, Scott ME, Beynnon BD, Fiorentino NM. Does interpolation and intra-user variability affect the accuracy of arthrokinematic measurements in the knee? A dual fluoroscopic imaging and model-based tracking study. Med Eng Phys. 2023 Apr;114:103968. doi: 10.1016/j.medengphy.2023.103968. Epub 2023 Mar 14. PMID: 37030894
Schuring LL, Mozingo JD, Lenz AL, Uemura K, Atkins PR, Fiorentino NM, Aoki SK, Peters CL, Anderson AE. Acetabular labrum and cartilage contact mechanics during pivoting and walking tasks in individuals with cam femoroacetabular impingement syndrome. J Biomech. 2023 Jan;146:111424. doi: 10.1016/j.jbiomech.2022.111424. Epub 2022 Dec 24. PMID: 36603366
Pius AK, Beynnon BD, Fiorentino N, Gardner-Morse M, Vacek PM, DeSarno M, Failla M, Slauterbeck JR, Sturnick DR, Argentieri EC, Tourville TW. Articular cartilage thickness changes differ between males and females 4 years following anterior cruciate ligament reconstruction. J Orthop Res. 2021 Jul 20. doi: 10.1002/jor.25142. Online ahead of print.
Beynnon BD, Fiorentino NM, et al. Combined Injury to the ACL and Lateral Meniscus Alters the Geometry of Articular Cartilage and Meniscus Soon After Initial Trauma. J Orthop Res. 2020 Apr;38(4):759-767. doi: 10.1002/jor.24519. Epub 2019 Nov 19.
Atkins PR, Fiorentino NM, et al. In Vivo Pelvic and Hip Joint Kinematics in Patients With Cam Femoroacetabular Impingement Syndrome: A Dual Fluoroscopy Study. J Orthop Res. 2020 Apr;38(4):823-833. doi: 10.1002/jor.24509. Epub 2019 Nov 14.
Fiorentino NM, et al. Soft Tissue Artifact Causes Significant Errors in the Calculation of Joint Angles and Range of Motion at the Hip. Gait Posture. 2017 Jun;55:184-190. doi: 10.1016/j.gaitpost.2017.03.033.
Stafford Hall
Room 411
Email: nfiorent@uvm.edu
Phone: +1 (802) 656 8082
Votey Hall
Room 231B
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