Musculoskeletal Imaging and Orthopaedic Biomechanics Laboratory

Improving musculoskeletal health through scientific investigations of structure and function


Dynamic Imaging of Joint Motion Using High-speed Dual Fluoroscopy


Imaging of Musculoskeletal Tissue Structure, Size and Composition


Joint Mechanics Estimation via Patient-Specific Computer Models


The overarching goal of the Musculoskeletal Imaging and Orthopaedic Biomechanics (MIOB) Laboratory is to improve human health and performance for those who suffer from musculoskeletal and orthopaedic conditions. Our approaches span experimental and computational methods. We use magnetic resonance imaging (MRI) to visualize disease and quantify anatomy, and we image bone motion directly with dynamic x-ray. Our computational studies combine patient-specific MR-based models with dynamic motion measurements to estimate internal tissue mechanics of orthopaedic tissues. Overall, the experimental and computational methods employed by the MIOB lab aim to improve health outcomes and reduce burdens imposed on patients and our healthcare system.

Lab News

Divya Pradip Roy and Sadegh Khodabandeloo join the MIOB Lab. Welcome Roy and Sadegh! 

The Lab Director, Dr. Fiorentino, was awarded a NIH 21 grant entitled, "Biomechanical Markers of PTOA after ACL Reconstruction and Meniscal  Resection."

Eduardo successfully defends his thesis entitled, "Knee Articular Cartilage Material Properties Estimation Through FEA." Great job Eduardo!

Katlyn Hall, a Biomedical Engineering undergraduate student working in the lab, presents her work entitled, "Computational Modeling of Knee Joints in Persons 6 Months after ACL Reconstruction," at UVM's Student Resarch Conference. Way to go Katlyn!

John ("Johnny") Ramsdell and Eduardo Valdez join the MIOB Lab. Welcome Johnny and Eduardo!

Select Publications from MIOB Lab Members 

Pius AK, Beynnon BD, Fiorentino N, Gardner-Morse M, Vacek PM, DeSarno M, Failla M, Slauterbeck JR, Sturnick DR, Argentieri EC, Tourville TW. Articular cartilage thickness changes differ between males and females 4 years following anterior cruciate ligament reconstruction. J Orthop Res. 2021 Jul 20. doi: 10.1002/jor.25142. Online ahead of print.

Beynnon BD, Fiorentino NM, et al. Combined Injury to the ACL and Lateral Meniscus Alters the Geometry of Articular Cartilage and Meniscus Soon After Initial Trauma. J Orthop Res. 2020 Apr;38(4):759-767. doi: 10.1002/jor.24519. Epub 2019 Nov 19.

Atkins PR, Fiorentino NM, et al. In Vivo Pelvic and Hip Joint Kinematics in Patients With Cam Femoroacetabular Impingement Syndrome: A Dual Fluoroscopy Study. J Orthop Res. 2020 Apr;38(4):823-833. doi: 10.1002/jor.24509. Epub 2019 Nov 14.

Fiorentino NM, et al. Soft Tissue Artifact Causes Significant Errors in the Calculation of Joint Angles and Range of Motion at the Hip. Gait Posture. 2017 Jun;55:184-190. doi: 10.1016/j.gaitpost.2017.03.033. 

Fiorentino NM, et al. Accuracy of Functional and Predictive Methods to Calculate the Hip Joint Center with Dual Fluoroscopy as a Reference Standard. Ann Biomed Eng. 2016 Jul;44(7):2168-80. doi: 10.1007/s10439-015-1522-1. Epub 2015 Dec 8. PMID: 26645080.

Handsfield GG, Knaus KR, Fiorentino NM, et al. Adding Muscle Where You Need It: Non-uniform Hypertrophy Patterns in Elite Sprinters. Scand J Med Sci Sports. 2016 Jul 4. doi: 10.1111/sms.12723.  

Fiorentino NM, et al. Computational models predict larger muscle tissue strains at faster sprinting speeds. Med Sci Sports Exerc. 2014 Apr;46(4):776-86. doi: 10.1249/MSS.0000000000000172. PMID: 24145724.  

Fiorentino NM, et al. Activation and aponeurosis morphology affect in vivo muscle tissue strains near the myotendinous junction. J Biomech. 2012 Feb 23;45(4):647-52. doi: 10.1016/j.jbiomech.2011.12.015. Epub 2012 Jan 10. PMID: 22236527.

Lab Address

Stafford Hall
Room 411


Phone: +1 (802) 656 8082 

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