Chem 258: Chemical Biology

Lectures
Mon/Wed/Fri 9:35 - 10:25 am, Angell B104

Learning objectives
1. Students will understand the interplay of observation, data collection, and hypothesis formulation and testing
2. Students will be able to read and critically evaluate the relevent scientific literature
3. Students will learn to present scientific data clearly and effectively through both written and verbal communication

Course Structure
The course is an advanced class that discusses how our ability to manipulate molecules allows us to discover and control biological function. The course is based on student presentation of relevant research papers and classroom discussion of those papers.

Presentation Schedule

Office Hours
Feel free to drop by my office any time. If you need to see me at a specific time, please make an appointment.

Email Questions
I strongly recommend students to send questions by email. If the question is relevant, I can post the answers to the whole class. If you don't want your question in the public domain, please mark your email confidential. I'll usually respond the same day.

Lecture Notes
Links to papers and notes are provided below.

Introductory Lecture

Lecture 1: Deubiquitinating Enzymes (ppt)

Lecture 2: Inhibitors of Protein/DNA Complexes

Lecture 3: Biomimetic Catalysis of Aminoacyl Transfer

Lecture 4: Optimization of Non-natural Nucleotides (ppt)

Lecture 5: Use of Artificial Intelligence in the Design of Small Peptide Antibiotics (ppt)

Lecture 6: Switch-Peptides: Tools for Identifying Anti-Amyloid Agents

Lecture 7: Heterotelechelic Polymers for Protein Conjugation

Lecture 8: GDNF fusion protein for targeted-drug delivery (ppt)

Lecture 9: A Comparative Study of Bioorthogonal Reactions with Azides (ppt)

Lecture 10: Antibody Interference with N-Acyl Homoserine Lactone-Mediated Bacterial Quorum Sensing