Department of Physics
82 University Place
University of Vermont
Burlington, VT 05405-0125
kelvin.chu at uvm.edu
My NSF contact information is here.
I am currently on assignment with the National Science Foundation in
the Office of International and Integrative Activities in the Office
of the Director.
From 2006-2012, I worked for the Vermont State EPSCoR organization to
build research and education infrastructure in Vermont. I served as
Senior Associate Director of the organization, which has oversight of
the EPSCoR and EPSCoR-like programs from the National Science
Foundation, National Institutes of Health, Department of Energy and
Department of Agriculture.
These duties included serving as Associate Director
for Vermont EPSCoR
the Vermont Genetics Network
(GM103449). In addition, I served on the Executive Committee
for the Northeast
Cyberinfrastructure Consortium (EPS-0918284).
My portfolio included evaluation and assessment, private sector
initiatives, and cyberinfrastructure initiatives.
In 2012, I accepted a position as a Program Officer in EPSCoR
office at the National Science Foundation. (link).
I received my Sc.B. in Physics from Brown University and my Ph.D. in
from the University of Illinois at Urbana-Champaign. I
was a Director's Postdoctoral Fellow at Los Alamos National
working on kinetic crystallography of heme proteins before coming
to UVM in 1998.
I am interested in the structural and functional consequences of
dynamics of biological molecules. The projects in my lab are
aimed at achieving a quantitative understanding of biological function
and enzyme mechanism. My interests include spectroscopy of
proteins and nucleic acids and the use of biomolecules in
nanotechnological applications. I am affiliated with the Center for X-ray
Crystallography and the Structural Biology
effort at UVM.
- Magnetic circular dichroism on small organic molecules (meso tetra-phenylporphyrin)
- Protein dynamics of heme proteins (myoglobin,
- K. Miller, N. Lasry, K. Chu and E. Mazur "Role of physics lecture
demonstrations in conceptual learning." Phys. Rev. St Phys. Educ. Res.9:020113 (2013). [Link]
- W. DeWitt and K. Chu "Imaging Protein Statistical Substate Occupancy in
a Spectrum-Function Phase Space." Phys.
Rev. Lett. 105:098101
- K. Chu “Determination of Reaction
Intermediate Structures in Heme Proteins.” Meth. Molec. Biol.,
Macromolecular Crystallography Protocols. The Humana Press, NJ, USA.
- H. Frauenfelder, B. H. McMahon, R.H. Austin, K. Chu
J.T. Groves "The role of structure, energy landscape, dynamics, and
allostery in the enzymatic function of myoglobin." Proc. Natl. Acad. Sci. USA
- I. Schlichting and K. Chu "Trapping intermediates in
crystal: ligand binding to myoglobin.” Curr. Opin. Struct. Biol.10:744-752 (2000). [Link]
- I. Schlichting, J. Berendzen, K. Chu, A.M. Stock,
Maves, D.E. Benson, R.M. Sweet, D. Ringe, G.A. Petsko and S.G. Sligar
"The catalytic pathway of cytochrome
P450cam at atomic resolution.” Science
- M. Brunori, B. Vallone, F. Cutruzzola, C.
Travaglini-Allocatelli, J. Berendzen, K. Chu, R.M. Sweet, and I.
Schlichting "The role of cavities in protein dynamics: crystal
structure of a novel photolytic intermediate of myoglobin" Proc. Natl. Acad. Sci., USA
- K. Chu, J. Vojtĕchovský, B.H. McMahon, R.M.
Sweet, J. Berendzen and I. Schlichting "Crystal structure of a new
ligand-binding intermediate in wildtype