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Major areas of Treatment Outcome Research

Treatment of Cocaine Abuse (Higgins):  We are currently involved in a 15-year outpatient project assessing the efficacy of behavioral interventions for treating cocaine dependence.

Cigarette Smoking During Pregnancy  (Higgins & Heil): Cigarette smoking during pregnancy is a major cause of preventable infant morbidity and mortality in the U.S.  This project examines the efficacy of voucher-based reinforcement therapy, originally developed by us for treatment of cocaine dependence, for promoting smoking cessation and preventing relapse among pregnant smokers.

Gradual vs. Abrupt Cessation (Hughes): We are comparing quitting smoking with these two methods aided by nicotine replacement.

Treatment of Nicotine Dependence (Hughes):  We are assessing why smokers do not use treatments for smoking cessation.

Treatment of Opioid Abuse (Sigmon, Heil & Higgins): The clinical pharmacology of opioid abuse and dependence is investigated in a 15-year program of research.  A series of studies are planned to examine methods to improve combined behavioral and pharmacological treatments with a special interest in prescription opioid abuse.

Treatment of Opioid-Dependent Pregnant Women (Heil): We are currently participating in a 5-year study that will be the first multi-site trial to assess the efficacy of buprenorphine for reducing neonatal abstinence relative to methadone in the offspring of opioid-dependent pregnant women.

Treatment of Cigarette Smoking (Heil & Higgins): This project builds on our prior research supporting a direct, causal relationship between early and later abstinence.  We are examining whether by increasing early abstinence, we can increase longer-term abstinence.

Last modified January 17 2007 02:46 PM

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