Major areas of Treatment Outcome Research
Treatment of Cocaine Abuse (Higgins): We are currently involved in a 15-year outpatient project assessing the efficacy of behavioral interventions for treating cocaine dependence.
Cigarette Smoking During Pregnancy (Higgins & Heil): Cigarette smoking during pregnancy is a major cause of preventable infant morbidity and mortality in the U.S. This project examines the efficacy of voucher-based reinforcement therapy, originally developed by us for treatment of cocaine dependence, for promoting smoking cessation and preventing relapse among pregnant smokers.
Gradual vs. Abrupt Cessation (Hughes): We are comparing quitting smoking with these two methods aided by nicotine replacement.
Treatment of Nicotine Dependence (Hughes): We are assessing why smokers do not use treatments for smoking cessation.
Treatment of Opioid Abuse (Sigmon, Heil & Higgins): The clinical pharmacology of opioid abuse and dependence is investigated in a 15-year program of research. A series of studies are planned to examine methods to improve combined behavioral and pharmacological treatments with a special interest in prescription opioid abuse.
Treatment of Opioid-Dependent Pregnant Women (Heil): We are currently participating in a 5-year study that will be the first multi-site trial to assess the efficacy of buprenorphine for reducing neonatal abstinence relative to methadone in the offspring of opioid-dependent pregnant women.
Treatment of Cigarette Smoking (Heil & Higgins): This project builds on our prior research supporting a direct, causal relationship between early and later abstinence. We are examining whether by increasing early abstinence, we can increase longer-term abstinence.
Incentives and Health (Higgins,
Heil, Sigmon): The topic of incentives and
is a major research priority of the Human Behavioral Pharmacology
Research Unit. We have extensive experience researching the use
incentives to promote healthy behavior change and hold numerous
NIH-funded research projects on this topic.
Smoking Abstinence Among Methadone
Maintenance (MM) Patients (Sigmon): Prevalence of
cigarette smoking among methadone maintenance (MM) patients is
three-fold that of the general population and is associated with
increased morbidity and mortality. Despite these statistics,
there is a dearth of scientific knowledge about how to effectively
reduce smoking among MM patients. The limited research thus far
suggests that contingency-management (CM) interventions may be
effective in this population. However, one commonality across the
existing studies is that none have been able to produce longer-term
smoking abstinence in this challenging population. The
overarching goal of this proposal is to produce an efficacious,
empirically-based smoking cessation intervention that can be easily
disseminated to methadone clinics throughout the country. Overall, the
proposed studies use a programmatic approach to enhance our
understanding of how to achieve short- and longer-term smoking
abstinence in MM patients. The proposed research also holds
significant potential for impacting the status of public health in
general, as development of efficacious smoking-cessation treatments
will help to reduce the vast economic and societal costs associated
with cigarette smoking among MM and non-MM smokers alike.
Last modified August 09 2010 03:55 PM