UVM logo

Information about Dwight E. Matthews, Ph.D.

DE Matthews photo, May 2019

Dr. Matthews receiving emeritus citation from UVM President Tom Sullivan, May 2019

Dwight E. Matthews

Areas of expertise:

Analytical chemistry, mass spectrometry, proteomics, metabolomics, stable isotope tracers, and metabolite flux and kinetic measurements

Contact information:

University of Vermont
Department of Chemistry
82 University Pl
Burlington, VT 05405
phone: 802 656-8114
office: Innovation Hall E339
lab: Discovery Hall W312B

ORCID ID: 0000-0003-2715-6104
Google scholar  H-index: 75







Prof. Matthews has been an analytical chemist and mass spectrometrist for over 30 years developing new methods for measurement of stable isotopically labeled biomolecules by mass spectrometry. The range of mass spectrometry developments accomplished cross from isotope ratio mass spectrometry (IRMS) and the initial development of continuous flow IRMS interfacing gas chromatography to an IRMS, to gas chromatography-mass spectrometry (GCMS) for metabolite measurement, to liquid chromatography-mass spectrometry (LCMS) for molecules ranging from metabolites to peptides and proteins. Method developments range from quantitative measurements of concentrations to quantitative measurements of stable isotopically labeled metabolites and peptides for determination of in cell and in vivo kinetics of metabolic pathways and synthesis of metabolites and whole proteins. The focus of his work has been use of the stable isotopes as tracers for measuring kinetic rates of metabolic processes in vivo in disease and in normal health. Many of the methods developed have become standard methods in a variety of investigator laboratories and have been applied world-wide to measure kinetics of endogenous metabolites. He has also directed core laboratories in mass spectrometry and metabolite measurement for over 25 years starting at Washington University in St. Louis, Cornell University Medical College, and today at the University of Vermont.

Contributions by Dr. Matthews:

EMAS vol 5 book cover

Complete list of published papers and works by Dr. Matthews: