Spätzle (SPZ)

Protein Structure: 253 aa's. The spätzle gene encodes a novel secreted protein that requires activation by a proteolytic processing reaction, which is present in the space that surrounds the embryo.
Activity: Activated SPZ is the ligand for receptor called: _________
Localization: In the fluid surrounding the embryo
Expression Pattern: constitutive and secreted
Modifications: Requires proteolytic processing for activity
Stability: disregard
Targets of Action: interacts with the extracellular domain of a receptor called: ___________