Faculty - Ying Wai Lam

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Ying Wai Lam, Director of the UVM/VGN Proteomics Facility, Research Assistant Professor

  • PhD (Biochemistry), The Chinese University of Hong Kong, 1998-2001
  • Postdoctoral Fellow, University of Massachusetts Medical School, 2001-2005
  • Research Assistant Professor, Department of Environmental Health, University of Cincinnati, 2005-2011
  • Research Assistant Professor, Department of Biology, University of Vermont, 2011-
  • Director of the Vermont Genetics Network (VGN) Proteomics Facility, University of Vermont, 2011-
Area of expertise

proteomics, biological mass spectrometry

CV (PDF)

Contact Information
Email: Ying Wai Lam

Office Hours: by appointment
Marsh Life Science Building, Rm 337
Phone: (802) 656-4709
Website: UVM/VGN Proteomics

Research

My research over the past ten years has focused on applying mass spectrometry-based strategies to address a diverse range of research questions at the interface of biochemistry, cell biology and analytical chemistry, especially those related to disease development. Particularly, I have applied conventional proteomic approaches, time-of-flight mass profiling, stable isotope tagging in conjunction with shotgun sequencing, and post-translational modified-site mapping techniques, to identify prostate cancer biomarkers, to elucidate the molecular mechanisms of aging and carcinogenesis, as well as to determine the impact of nitrosative stress-induced protein modifications (e.g. nitrosylation on cysteines) on signaling pathways. I am also interested in characterizing small molecules using liquid chromatography-high resolution accurate mass measurement (HR/AM).

UVM/VGN proteomics facility is supported by the National Institute of General Medical Sciences of NIH [IDeA Networks of Biomedical Research (INBRE); Vermont Genetics Network at The University of Vermont (VGN)]. The goals of our facility are to provide expertise and the latest proteomics technology to researchers at different institutions in Vermont and to establish an educational environment for sharing experience and knowledge in proteomics. An array of mass spectrometry-based techniques is available to investigators for performing proteomics experiments, ranging from routine protein identification, post-translational modification (PTM) characterization, to large-scale quantitative proteomics (global profiling of protein expression and PTMs) with stable isotopes.

The facility works directly with over 100 UVM faculty, staff/postdocs, and graduate students, providing guidance and support for their proteomics projects from initial experimental design, sample preparation, instrument operation, to data analysis and interpretation. We also assist investigators in initiating proteomics projects, manuscript preparation and grant submissions.

Please don’t hesitate to contact us if you think your research might benefit from our expertise. We love to solve challenging problems, and will work hard to develop the best strategies to answer your proteomics questions! Please check out our UVM/VGN proteomics website for more information!

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Proteomics Facility Brochure

Selected Publications


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