Publications

Proteomic and Signaling Studies of the Brain: 

• B.A. Ballif, G.R. Carey, S. Sunyaev, S.P. Gygi, Large-Scale Identification and Evolution Indexing of Tyrosine Phosphorylation Sites from Murine Brain. Journal of Proteome Research, 2008. 7:311-8. Abstract
• E.C. Connors, B.A. Ballif, A.D. Morielli. Homeostatic regulation of kv1.2 postassium channel trafficking by cyclic AMP.  J Biol Chem. 2008, 283:3445-53. Abstract 
• M.D. Zappaterra, S.N. Lisgo, S.Lindsay, S.P. Gygi, C.A. Walsh and B.A. Ballif. A Comparative Proteomic Analysis of Human and Rat Embryonic Cerebrospinal Fluid. Journal of Proteome Research, 2007, 6:3537-48. Abstract
• B.A. Ballif, Z. Cao, D. Schwartz, K. Carraway III and S.P. Gygi. Identification of 14-3-3epsilon Substrates from Embryonic Murine Brain. Journal of Proteome Research, 2006, 5:2372-79. Abstract
• B.A. Ballif, J. Villén, S.A. Beausoleil, D. Schwartz and S.P. Gygi. Phosphoproteomic analysis of the developing mouse brain. Molecular and Cellular Proteomics, 2004, 3:1093-101. Abstract
• B.A. Ballif, L. Arnaud, W.T. Arthur, D. Guris, A. Imamoto and J.A. Cooper. Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Current Biology, 2004,14:606-10. Abstract
• L. Arnaud, B.A. Ballif and J.A. Cooper. Regulation of protein tyrosine kinase signaling by substrate degradation during brain development. Molecular and Cellular Biology, 2003, 23:9293-302. Abstract
• B.A. Ballif, L. Arnaud and J.A. Cooper. Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases. Brain Research Molecular Brain Research, 2003, 117:152-9. Abstract
• L. Arnaud, B.A. Ballif and J.A. Cooper. Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Current Biology, 2003, 13:9-17. Abstract

Signaling Studies in Cell Survival, Growth and Proliferation:

• Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC. Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Regulation of mTOR complex 1 (mTORC1) by raptor S863 and multi-site phosphorylation. J Biol Chem. 2009. In Press. Abstract
• Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC. Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.Mol Cell Biol. 2009, 29:4308-24. Abstract
  
• Deng M, Li F, Ballif BA, Li S, Chen X, Guo L, Ye X. Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. J Biol Chem. 2009, 284:7875-88. Abstract
• Yoon SO, Shin S, Liu Y, Ballif BA, Woo MS, Gygi SP, Blenis J. Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport. Mol Cell. 2008, 29:362-75. Abstract
• M.K. Holz, B.A. Ballif, S.P. Gygi, and J. Blenis. mTOR and S6K1 mediate assembly of the translation pre-initiation complex through dynamic protein:protein interchange and ordered protein phosphorylation events. Cell, 2005, 123:569-80. Abstract
• R. Anjum, P.P. Roux, B.A. Ballif, S.P. Gygi and J. Blenis. The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Current Biology, 2005, 15:1762-7. Abstract
• B.A. Ballif*, P.P. Roux*, S.A. Gerber, J.P. MacKeigan, J. Blenis and S.P. Gygi. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proceedings of the National Academy of Sciences USA, 2005,102:667-72. *Equal Contribution Abstract
• P.P. Roux, B.A. Ballif, R. Anjum, S.P. Gygi and J. Blenis. Tumor promoting phorbol esters and activated Ras inactivate the Tuberous Sclerosis Tumor Suppressor Complex via RSK. Proceedings of the National Academy of Sciences USA, 2004, 101:13489-94. Abstract
• C.J. Richardson, M. Bröenstrup, D.C. Fingar, K. Jülich, B.A. Ballif, S.P. Gygi and J. Blenis. SKAR is a specific target of S6 kinase 1 in cell growth control. Current Biology, 2004, 14:1540-9. Abstract
• B.A. Ballif and J.Blenis. Molecular mechanisms mediating mammalian MEK-MAP Kinase cell survival signals. Cell Growth and Differentiation, 2001, 12:397-408. Abstract
• B.A. Ballif, A. Shimamura, E. Pae and J. Blenis. Disruption of 3-Phosphoinositide Dependent Kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent N-alpha-tosyl-L-phenylalanyl Chloromethyl Ketone. Journal of Biological Chemistry, 2001, 276:12466-12475. Abstract
• A. Shimamura*, B.A. Ballif*, S.A. Richards and J. Blenis. RSK1 mediates a MEK-MAPK cell survival signal. Current Biology, 2000, 10:127-135. *Equal Contribution Abstract

Signaling Studies in DNA Damage:

• S. Matsuoka, B.A. Ballif, A. Smogorzewska, E.R. McDonald 3rd, K.E. Hurov, J. Luo, C.E. Bakalarski, Z. Zhao, N. Solimini, Y. Lerenthal, Y. Shiloh, S.P. Gygi, S.J. Elledge. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science, 2007, 316:1160-6. Abstract
• B. Wang, S. Matsuoka, B.A. Ballif, D. Zhang, A. Smogorzewska, S.P. Gygi, and S.J. Elledge. Abraxas and Rap80 form a novel BRCA1 protein complex required for the DNA damage response. Science, 2007, 316:1194-8. Abstract
• A. Smogorzewska, S. Matsuoka, P. Vinciguerra, E.R. McDonald 3rd, K.E. Hurov, J. Luo J, B.A. Ballif, S.P. Gygi, K. Hofmann, A.D. D'Andrea, S.J. Elledge. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell, 2007, 129:289-301. Abstract

Additional Studies:

• AT Heaslip, JM Leungl, KL Careyl, F Catti, DM Warshaw, NJ Westwood, B.A. Ballif, and GE Ward. A small-molecule inhibitor of T. gondii motility and invasion induces the posttranslational modification of myosin light chain-1 and inhibits parasite myosin motor activity. PLOS Pathogens. Accepted.
  
• Miller MS, Lekkas P, Braddock JM, Farman GP, Ballif BA, Irving TC, Maughan DW, Vigoreaux JO. Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila. Biophys J. 2008, 95:2391-401. Abstract
• Miller MS, Lekkas P, Braddock JM, Farman GP, Ballif BA, Irving TC, Maughan DW, Vigoreaux JO. Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila. Biophys J. 2008, 95:2391-401. Abstract
• W.M. Brieher, H.Y. Kueh, B.A. Ballif, and T.J. Mitchison. Rapid, actin monomer insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. Journal of Cell Biology, 2006, 175:315-24. Abstract
• J. Li, B.A. Ballif, A.M. Powelka, J. Dai, S.P. Gygi and V. Hsu. Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin ß1 to control cell migration. Developmental Cell, 2005, 9:1-11. Abstract
• B.A. Ballif, N.V. Mincek, J.T. Barret, M.L. Wilson and D.L. Simmons. Interaction of Cyclooxygenases-1 and -2 with an apoptosis and autoimmunity-associated protein.Proceedings of the National Academy of Sciences, USA, 1996, 93:5544-5549. Abstract