Doctoral and Postdoctoral Training
Postdoctoral Fellow (2003-2006)
Department of Cell Biology,
Harvard Medical School
Dr. Steven P. Gygi,
Postdoctoral Fellow (2001-2003)
Division of Basic Sciences,
Fred Hutchinson Cancer
Dr. Jonathan A. Cooper, advisor
Department of Cell Biology,
Harvard Medical School
Dr. John Blenis, advisor
in the Ballif lab is primarily focused on elucidating molecular
mechanisms of signal transduction with two major emphases:
genetically-defined signaling pathways regulating vertebrate brain
development and (B) core signaling pathways regulating cell
proliferation, growth and survival. In addition to biochemical and
cell biological approaches,
we employ mass spectrometry-based proteomics as a primary tool to
identify and quantitatively monitor proteins, their
modifications and their interactions with other proteins following
acute signal administration or across
developmental stages. We are also using zebrafish, drawing on the expertise of our sister lab headed by Alicia Ebert, as an
organismal model system to study signaling pathways
regulating development, particularly neuronal positioning.
second focus of our work involves developing and applying proteomic
methodology to advance diverse lines of biological inquiry, some of
which have had little to no interface with proteomics. This makes these
projects both exciting and challenging. These collaborative projects
range from the identification of novel human blood group antigens; to
the identification of host proteins that interact with arenavirus
proteins; to targeted proteomic characterizations of wasps, pitcher
plant ecosystems, ants, fruit flies, unicellular ciliates and parasitic protozoa.
Thanks to our Funding Sources
*NIH--The Vermont Genetics Network (the INBRE program of NIGMS), The COBRE program of NIGMS, DHHS
*NSF--Divisions: IOS and DEB
*UVM--the Department of Biology, the College of Arts and Sciences and the Office of the VP of Research
|In The News|
|--Gwen Buel discusses her Ph.D. work at Harvard and how UVM served as a springboard to her graduate program.|
-- Karen awarded Norwich Board of Fellows Prize
-- Career Center Highlights Anh-Thu's work at Harvard and Children's Hospital
-- Peter's Fulbright and Graduate Work at Cardiff Highlighted in UVM Today.
-- Read about the publication of Honors Theses work by Tyler and Miranda (pg. 9).
-- Read about Bior's service to strengthen his native South Sudan.
-- Peter Doubleday receives Fulbright Schloarship to study at Cardiff University in the UK!
-- Read about sundry goings-on in the Biology Department at UVM.
-- 60 year old Blood Mystery Solved. Read about the identification of a third novel blood group system (Vel).
-- Discovery of Vel negative blood type highlighted in NIGMS "Spotlights on Hot Science."
-- Blood Mystery Solved. Read about the identification of two novel blood group systems (Lan and Jra).
(Ou si vous préférez les actualités en français et vous voulez connaître le chef et l'équipe principale des études!)
(Or if you prefer in Russian!)
-- College of Arts and Sciences Newsletter highlights NSF grant and Max Planck Institute Seminar.
-- Department of Biology Newsletter February 2010 part II
-- Department of Biology Newsletter February 2010 part I
-- Vermont Quarterly spotlight on the honors thesis work of Tyler Aten.
-- Try to find former lab members Tyler Aten and Marie Kenney in UVM's new ad series.
-- Read about Violet Rosken's work collecting wasps in Singapore.
-- Love of Lab Work Leads Grad to Harvard.
-- UVM Researchers Use Proteomics to Investigate the Evolution of Digestive Functions in Wasp Colonies
--The Complex Composition of Embryonic Cerebral Spinal Fluid
-- A Touching Response to DNA Damage
-- Biologist Reports in Science on DNA Damage
Lab Members Presenting their work at Conferences:
UVM Student Research Conference 2015
Top Panels (left to right): Ryan Joy, Jaye Grundy, Liam Kelley, Marion Weir and Riley St. Clair;
Sarah Emerson, Sarah Light, Ashley Waldron, Erin Wysolmerski (Ebert Lab)
Middle Panels (left to right): Jaye Grundy, Hannah Johnson, Ryan Joy and Liam Kelley
Bottom Panels (left to right): Amanda Northrop; Amanda Meyer and Katie Miller (Helms Cahan Lab colloborators);
John Gonzalez, Jenna Todero and Ben Flinn (Deming Lab)
Experimental Biology 2015, Boston, MA
from top left: Paula Deming and Marion Weir; Ryan Joy, Marion Weir and
Paula Deming; Karen Hinkle and Marion Weir; Marion Weir and Ryan Joy.
Vermont Chapter for the Society of Neuroscience/UVM NBH Forum 2015
Bryan Ballif, Ashley Waldron, Sarah Emerson, Riley St. Clair, Sarah Light, Marion Weir, Erin Wysolmerski and Alicia Ebert
Session talk by Riley St. Clair (above) and Poster Presentations (clockwise from top left below):
Ashley Waldron, Sarah Light, Marion Weir, Erin Wysolmerski
Society for Developmental Biology 2014 (Woods Hole, MA) From left:
Riley St. Clair, Erin Wysolmerski, Marion Weir and Ryan Joy.
UVM/NSF REU Summer Neuroscience Undergraduate Research Fellowship Conference 2015:
Left to right: Sierra Bruno, Alicia Ebert, Kori Williams, Sarah Light, Riley St. Clair, Erin Wysolmerski and Bryan Ballif
2014 Student Research Conference. Clockwise from top left: Rachael
Bassett, Erin Wysolmerski, Riley St. Clair, Jon Karp, Marion Weir and
VT Chapter of the Society for Neuroscience 2014:
Zebrafish Alley--in collaboration with Alicia Ebert (left to right): Erin Wysolmerski, Ryan Joy and Rachael Bassett.
UVM/NSF REU Summer Neuroscience Undergraduate Research Fellowship Conference 2014:
Left to right: Rachael Bassett, Marion Weir, Kristen D'Elia, Alicia Ebert and Bryan Ballif
UVM 2013 Student Research Conference:
Left to right: Peter Doubleday, Marion Weir, Jon Karp and Bryan Ballif
Karen and Zac at the VGN Career Day Conference
Peter at the HUPO 2012 conference.
Bryan presenting Mujeeb's and Bior's posters at the HUPO 2012 conference.
Peter, Marion (above) and Miranda (below) at the UVM Student Research Conference 2012.
Mujeeb presenting at ASMS 2011 in Denver, CO.
Rima presenting at the 2011 Signal Transduction Gordon Research Conference in Lewiston, ME.