University of Vermont

University of Vermont Clinical Research Center

Current CRC studies

Current CRC Protocols


830 Dr. Naomi K. Fukagawa

DIABETES IS ON THE RISE……

What can YOU do to help better understand the disease?

Everyone has heard that there is an epidemic of diabetes mellitus (DM) and obesity in the U.S. Older individuals are at high risk for developing DM and many of the complications associated with the disease, such as heart disease, kidney failure and impaired sensation. All of this contributes to increased disability and increased health care costs. An individual’s antioxidant status may influence his/her susceptibility to the complications associated with DM. We are investigating how a person makes glutathione (GSH), an antioxidant that your body makes and which makes up the largest pool of antioxidants in your body. Antioxidants help to detoxify free radicals, and low levels of GSH are associated with advancing age as well as DM. This investigation involves 3 studies which will be conducted in the General Clinical Research Center (GCRC) at the University of Vermont and Fletcher Allen Healthcare. We will determine your ability to make GSH and whether a nutritional supplement could influence your responses. Participation in this investigation will involve eating a standardized diet provided by the GCRC for 4 days prior to each study. In addition, your metabolic rate, body composition and general health will be assessed. You will be compensated for your time and participation.

We are recruiting healthy, nondiabetic men and women over 60 years of age and diabetic men and women over 60 years of age whose diabetes is managed by diet alone or with medications. If you are interested, please call 656-4403 and leave your name and contact number. You may also email Dr. Fukagawa at Naomi.Fukagawa@uvm.edu.


965 Dr. Naomi Fukagawa

CAN NUTRITIONAL SUPPLEMENTS ENHANCE YOUR EXERCISE PERFORMANCE?

Investigators at the University of Vermont and Fletcher Allen Health Care are conducting a research study to determine whether 4 weeks of supplementation with specific amino acids (building blocks of protein) will improve your exercise performance.

Volunteers must be between 18-35 years of age, in good health and physically active but not engaged in competitive sports or specific physical performance training.   Study includes body composition analysis, nutritional assessment, and exercise testing.  Participants will be paid $350 for completing the study.

INTERESTED IN LEARNING MORE???
Please contact Naomi Fukagawa at (802) 656-4403 or via email  Naomi.Fukagawa@uvm.edu.


 

1001 Dr. Lawrence Kien

DIET FAT COMPOSITION AND BRAIN FUNCTION IN YOUNG WOMEN

We are seeking ways to understand how different dietary fats may influence brain function and affect immunity.  Our study focuses on the two most prevalent fats (fatty acids) in the diet and in body tissues: palmitic acid, a saturated fat, and oleic acid, a monounsaturated fat.
 
Please examine the information below about the study and if you are still interested, please complete the attached subject intake form and email it back to me at nutritionresearch@uvm.edu Please don’t worry about calculating kg, cm and BMI as that is done via my computer.  The next step is a personal interview with me, during which the study will be thoroughly explained (and written consent obtained prior to screening).

RESEARCH PROCEDURES WILL INCLUDE:
  • Eligibility screening: a history/physical and fasting blood work, an oral glucose tolerance test, and an exercise test.
  • For 56 days (8 weeks), eating only food and drink (except water) provided by the General Clinical Research Center (GCRC).  During this period, you will have to eat breakfast every day of the week, except Saturday and Sunday, at the GCRC. Other meals can be picked up in the morning and eaten elsewhere.  The diet will be free of foods often considered problem foods to people trying to maintain or lose weight.  Food intake will be adjusted as necessary to prevent weight loss or gain.
  • Your body fat will be measured three times (DEXA) and you will have a training session and two functional magnetic resonance imaging (fMRI) scans.
  • Three mornings during the study period you will come in to the GCRC by 7:00 a.m. and blood samples will be collected. During two of these visits, non-invasive metabolic testing will also be performed.
  • Since there will be tests during portions of nine mornings during the two month period, you may miss some work or school. For this inconvenience and for the other times you must appear during the study, you will be reimbursed $1,000 for completing all tests for the study but will be eligible for partial reimbursement for completing portions of the study.
ELIGIBILITY FOR THE STUDY:
  • You must be healthy, without chronic disease.  Generally, this means you are not taking prescription medication (exception: thyroid replacement therapy). 
  • You must not be a vegetarian.  Additionally, you must be able to consume some “fat-free” dairy products during the study.
  • Age must be > 18 and < 41 years old.
  • Volunteers with both lean and overweight body types will be studied. 
  • Women who are not taking hormonal contraceptives must avoid pregnancy during the study. 
  • Subjects will be excluded from eligibility who engage in daily, very vigorous aerobic physical activity, as in people training continually for athletic events such as triathlons or marathons.  If you are not currently involved in serious athletic training, you may be eligible.

If interested:

DIETARY FAT COMPOSITION AND BRAIN FUNCTION IN OLDER WOMEN

We are seeking ways to understand how different dietary fats may influence brain function and affect immunity.  Our study focuses on the two most prevalent fats (fatty acids) in the diet and in body tissues: palmitic acid, a saturated fat, and oleic acid, a monounsaturated fat.
 
Please examine the information below about the study and if you are still interested, please complete the attached subject intake form and email it back to the following address: dietandbrain@uvm.edu Please don’t worry about calculating kg, cm and BMI as that is done via my computer.  The next step is a personal interview with one of the study coordinators, during which the study will be thoroughly explained (and written consent obtained prior to screening).

RESEARCH PROCEDURES WILL INCLUDE:
  • Eligibility screening: a history/physical and fasting blood work and an oral glucose tolerance test.
  • For 56 days (8 weeks), eating only food and drink (except water) provided by the General Clinical Research Center (GCRC). During this period, you will have to eat breakfast every day of the week, except Saturday and Sunday, at the GCRC. Other meals can be picked up in the morning and eaten elsewhere. The diet will be free of foods often considered problem foods to people trying to maintain or lose weight. Food intake will be adjusted as necessary to prevent weight loss or gain
  • Your body fat will be measured three times (DEXA) and you will have a training session and two functional magnetic resonance imaging (fMRI) scans.
  • Three mornings during the study period you will come in to the GCRC by 7:00 a.m. and blood samples will be collected. During two of these visits, non-invasive metabolic testing will also be performed.
  • Since there will be tests during portions of four mornings during the two month period, you may miss some work or school. For this inconvenience and for the other times you must appear during the study, you will be reimbursed $1,000 for completing all tests for the study but will be eligible for partial reimbursement for completing portions of the study.
ELIGIBILITY FOR THE STUDY:
  • You must be a healthy woman age 50 to 60 years, without chronic disease.  Generally, this means you are not taking prescription medication (exception: thyroid replacement therapy). 
  • You must not be a vegetarian.  Additionally, you must be able to consume some  “fat-free” dairy products during the study.
  • You must have had no menstrual periods for the last year and not be receiving any form of sex hormone replacement.
  • Volunteers with both lean and overweight body types will be studied.
  • Subjects will be excluded from eligibility who engage in daily, very vigorous aerobic physical activity, as in people training continually for athletic events such as triathlons or marathons.  If you are not currently involved in serious athletic training, you may be eligible.

    We look forward to hearing from you.

    If interested:

    Please fill out this subject intake form and email it to: dietandbrain@uvm.edu


    M09-064B - Dr. Alexandra Potter, PhD

    Brain Function and ADHD – A study of the effects of nicotine and Ritalin.

    18-25 year olds with ADHD are needed to participate in research looking at patterns of brain activation associated with nicotine and Ritalin.
    Volunteers will complete three 6-hour study visits in which they will receive nicotine alone, Ritalin alone, or placebo. Study visits include a 1-hour fMRI (brain scan).
    Compensation up to $300.
    If you are interested in finding out more, call Eva at 847-5444.


    M12-142 Dr. Beth Kirkpatrick and the Vaccine Testing Center

    Current Study 2012: Dengue Fever Vaccine study

    This exciting research study aims to test the effectiveness and safety of an experimental vaccine for the prevention of dengue fever. This vaccine, but a different lot, has already been tested in another trial and was generally well-tolerated. This current research trial will evaluate a new lot of this vaccine, and the results will be compared with those of the previous trial.


    The study has been designed for maximum volunteer safety and has been approved by the U.S. Food and Drug Administration (FDA), the UVM Institutional Review Board and the UVM Biosafety Committee.


    Volunteers' responsibilities will be fully explained during the first visit. These include one screening visit, two dosing visits and 22 additional follow up outpatient visits. Volunteers will receive either the research vaccine or a placebo, and will be asked to keep a daily record of their temperatures over the first 16 days of the study.


    Dengue fever is rare in this country but common in most tropical and subtropical regions of the world, where about 50-100 million cases have been reported per year. We hope that this research study will lead to a vaccine that will protect human populations against this viral infection.


    Click on the following links for information about the disease, Dengue fever.  
    http://www3.niaid.hih.gov/topics/DengueFever/
    http://wwwn.cdc.gov/travel/yellowbook/ch4/dengue-fever.aspx
    Thank you!

    Cathy Larsson
    Vaccine Testing Center
    University of Vermont, College of Medicine
    vaccinetestingcenter@uvm.edu
    phone:     656-0013  fax:         656-0881


    M14-147 Dr. Julie Dumas, PhD

    Seeking healthy 60-70 year old women for a one-visit research study (approx. 3 hours in length) to help us learn about how the brain is affected by hormones throughout life.  This University of Vermont study will consist of completing questionnaires, computer memory tests, and the collection of a cheek swab for DNA analysis. We are seeking healthy non-smoking women who are not currently taking anti-depressants. You will be compensated $25 for the visit.

    For more info, call Jenni at 802-847-4081

     

    Last modified July 17 2014 09:33 AM

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