Biochemistry I: Protein Structure and Function, Metabolism

Meeting Time
Mon/Wed/Fri 10:10 - 11:00, Lafayette 207

Dr. Case's Office Hours
You're free to drop by my office any time.  If you need to see me for more than half an hour, please make an appointment and I'll make sure I'm available.

Email Questions
I encourage students to contact me by email. If the questions are general, I'll post the replies to the class. In these cases the original questioner will remain anonymous. If you don't want your question in the public domain, please mark your email "personal" and I'll reply individually.

Review Sessions
If more than ten students request a review, I will reserve a classroom at an agreed time.

Required Text
Biochemistry 3rd Edition, 2005, Garrett & Grisham

Prerequisites
Chem 142 or Chem 144 Organic Chemistry

Organization for Fall Semester

Problem Sets 6 x 5% 30% Exams 4 x 15% 60% Quizzes 10%   100%

PROBLEM SETS

Problem Set 1 Problem Set 2 Problem Set 3 Problem Set 4 Problem Set 5 Problem Set 6 Answer Key 1 Answer Key 2 Answer Key 3 Answer Key 4 Answer Key 5 Answer Key 6

About Problem Sets
Problems sets will be assigned throughout the course. Homework is ABSOLUTELY due by the end of class on the due date. Late homework will be severely penalized. Homework will be returned as soon as possible, and an answer key posted as soon as grading is complete.

LECTURES

Lecture 1: Introduction & Review of Fundamentals Lecture 2: Water, pH and pKa Lecture 3: Thermodynamics Lectures 4-5: Amino Acids and Polypeptides Lectures 6-8: Protein Architecture: Primary, Secondary, Tertiary and Quarternary Structure Lectures 9-10: Protein Folding and Stability Lecture 11: Evolution, Function and Classification of Proteins Lecture 12: Introduction to Enzyme Kinetics Lectures 13-15: Michaelis Menten Kinetics Lectures 16-18: Enzymes: Mechanisms, Regulation and Allostery Lecture 19: Allostery Lecture 20: Introduction to Metabolism Lecture 21: The Energetics of Metabolism Lectures 22-23: Glycolysis Lectures 24-26: The Tricarboxylic Acid Cycle Lectures 27-28: Gluconeogenesis Lectures 29-31: Oxidative Phosphorylation Lectures 32-34: Photosynthesis Lectures 35-37: Fatty Acid Metabolism

Lecture notes can be downloaded as pdf files.

OTHER MATERIAL

Course Syllabus Helix Coordinates Glycolysis - Molecules of the Month DIY Glycolysis Oxidative Phosphorylation Animation Useful Links

About Exams

Exams will last 120 minutes. Absence from an exam requires prior approval from the instructor. If you have any scheduling conflicts, please notify Dr. Case prior to the exam to reschedule. Exams are closed-book, closed-note exams; no class materials may be used and no outside help may be used. Due to potential scheduling conflicts, you are not allowed to discuss the exams with anyone else until the answer key is posted.

Exam I: Monday 9/25 from 7:00 - 9:00 pm, Lafayette L207 (Lectures 1 - 11)
Exam II: Monday 10/23 from 7:00 - 9:00 pm, Lafayette L207 (Lectures 12 - 19)
Exam III: Monday 11/13 from 7:00 - 9:00 pm, Lafayette L207 (Lectures 20 - 28)
Exam IV: Tuesday 12/12 from 8:00 - 11:00 am, Lafayette L207 (Lectures 29 - 37)