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The DNA Microarray Core Facility was initiated by the Vermont
Genetics Network and recently established at UVM in collaboration with VCC
and the UVM College of Medicine. This facility utilizes the Affymetrix
GeneChip system that includes hybridization and fluidics stations and
a scanner.
An Agilent
2100 Bioanalyzer
is also available for RNA analysis. Affymetrix GeneChip expression analysis
arrays are available for human, mouse, rat, yeast and other organisms.
The microarray core is also equipped with a variety of tools for data
analysis, networking and database management. Data are analyzed using
the Microarray Suite, DMT, Micro DB and Genespring software packages.
The Microarray Core provides RNA expression-profiling services including
quality testing of RNA, hybridization to GeneChip probe arrays, image
processing, primary data analysis, data delivery, and access to Bioinformatics
tools, which are managed by the Bioinformatics Core. Seminars are arranged
for an overview of the Affymetrix probe array technology and data analysis
using various software packages. The DNA Microarray Core's expert
staff perform array-based experiments on gene expression, and are available
to give advice and consultation to researchers.
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