Pfam: HSP20

PRODOM only

These entries have been identified as being related to this entry using only PRODOM

Pfam entry HSP20

Figure 1: 1gme
Chaperone
Crystal structure and assembly of an eukaryotic small heat shock protein

Key:
Domain Chain Start Residue End Residue
HSP20 A 47 150
HSP20 B 47 150
HSP20 C 47 150
HSP20 D 47 150

The Swissprot/PDB mapping was provided by MSD

Accession number: PF00011

Hsp20/alpha crystallin family

This family forms interactions with other Pfam families, to view them click here

Clan: HSP20-like chaperone superfamily

This family is a member of the HSP20-like chaperone superfamily clan. This clan includes the following Pfam members: CS; HSP20;

INTERPRO description (entry IPR002068 )

Prokaryotic and eukaryotic organisms respond to heat shock or other environmental stress by inducing the synthesis of proteins collectively known as heat-shock proteins (hsp) PUBMED:2853609. Amongst them is a family of proteins with an average molecular weight of 20 Kd, known as the hsp20 proteins PUBMED:7925426. These seem to act as chaperones that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Structurally, this family is characterized by the presence of a conserved C-terminal domain of about 100 residues.

For additional annotation, see the PROSITE document PDOC00791 [Expasy|SRS-UK]

Alignment Domain organisation

Seed (37) Full (1190)

Format

Further alignment options here
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View 4 representative architectures
View architectures for 1190 proteins

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Species Distribution Phylogenetic tree

View alignments & domain organisation by species
Tree depth :

Seed (37) Full (1190)

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Database References

PDB
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PFAMB
PRODOM only:PB020439 PB037982 PB048076 PB070698 PB118031 PB121043 PB121054 PB124140 PB125536 PB126920
PRINTS
This prints entry is a subset of the Pfam entry. PR00299

PROSITE PDOC00791 [Expasy|SRS-UK]

COGS
COG0071

SYSTERS HSP20
PANDIT HSP20
FUNSHIFT HSP20

Literature References
1.
Crystal structure of a small heat-shock protein.
Kim KK, Kim R, Kim SH
Nature 1998;394:595-599.

Pfam specific information
Author of entry Sonnhammer ELL

Type definition Family

Source of seed members Prosite

Average Length 92.6

Average %id 25

Average Coverage 58.26%

HMMER build information
Pfam_ls [Download HMM] Pfam_fs [Download HMM]
Gathering cutoff 13.0 13.0; 11.0 11.0

Trusted cutoff 13.3 13.3; 11.1 11.1

Noise cutoff 12.9 12.9; 10.9 10.9

Build method of HMM hmmbuild -F HMM_ls SEED
hmmcalibrate --seed 0 HMM_ls
hmmbuild -f -F HMM_fs SEED
hmmcalibrate --seed 0 HMM_fs

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