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Click to Display mRNA-Genomic Alignments (spanning 14620 bps)

Homo sapiens Official Gene Symbol and Name (HGNC)

	ADH1A: alcohol dehydrogenase 1A (class I), alpha polypeptide
	LocusID: 124

Overview

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	RefSeq Summary: This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. This gene is monomorphic and predominant in fetal and infant livers, whereas the genes encoding beta and gamma subunits are polymorphic and strongly expressed in adult livers.
	ProteomeSummary: Alcohol dehydrogenase 1 (alcohol:NAD+ oxidoreductase) class I alpha subunit; oxidizes ethanol
	Locus Type:	gene with protein product, function known or inferred
	Product:	class I alcohol dehydrogenase, alpha subunit
	Alternate Symbols:	ADH1
	Alias:	ADH, alpha subunit  aldehyde reductase  alcohol dehydrogenase 1  alcohol dehydrogenase 1 (class I), alpha polypeptide

Function

Submit GeneRIF

(All Pubs)

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EC Number:  1.1.1.1

	Gene OntologyTM:
	Term	Evidence	Source	Pub
	zinc binding	E	Proteome	pm
	ethanol oxidation	E	Proteome	pm
	ethanol metabolism	NR	Proteome
	electron transporter	E	Proteome	pm
	alcohol dehydrogenase, zinc-dependent	E	Proteome	pm
	Other Ontologies:
	Term	Evidence	Source	Pub
	Oxidoreductase	E	Proteome	pm

Relationships

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	Mouse Homology Maps:
	NCBI vs. MGD		3 71.20 cM	Adh1	HsMm
	UCSC vs. MGD		3 71.20 cM	Adh1	HsMm

Map Information

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	Chromosome:	4			mv
	Cytogenetic:	4q21-q23		HUGO

NCBI Reference Sequences (RefSeq)

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Category: REVIEWED

	mRNA:	NM_000667
	Protein:	NP_000658  class I alcohol dehydrogenase, alpha subunit		BL
	Domains:	Zinc-binding dehydrogenases	score: 738
	GenBank Source:	M12271,M12963