Summary

Li Fraumeni syndrome is a genetic disease associated with childhood cancers.

Mutations in TP53 may cause Li Fraumeni syndrome

TP53 stimulates the transcription of genes that inhibit cell division, consistent with the association of TP53 mutations with cancers.

One prominent Li Fraumeni mutation functions in protein-DNA recognition.

Using only NCBI web resources, we have performed a research project that included sequence, structure, evolution, function, and phenotype.

Last
Next