Publications from 1995... (linked to abstracts from 2000)
  1.  Janssen YMW, Barchowsky A, Treadwell M, Driscoll KE and Mossman BT:  Asbestos induces nuclear factor kB (NF-kB) DNA-binding activity and NF-kB-dependent gene expression in tracheal epithelial cells.  Proc. Natl Acad Sci USA 92:8458-8462, 1995.
  2.  Driscoll KE, Hassenbein DG, Carter JM, Kunkel SL, Quinlan TR and Mossman BT:  TNF? and increased chemokine expression in rat lung after particle exposure.  Toxicol Lett 82/83:483-489, 1995.
  3.  Quinlan TR, BeruBe KA, Marsh JP, Janssen YMW, Taishi P, Leslie KO, Hemenway D, O'Shaughnessy PT, Vacek P and Mossman BT:  Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos.  Am J Pathol 147:728-739, 1995.
  4.  Timblin CR, Janssen YWM, Mossman BT:  Transcriptional activation of the proto-oncogene c-jun, by asbestos and H2O2 is directly related to increased proliferation and transformation of tracheal epithelial cells. Cancer Res 55:2723-2726, 1995.
  5.  Janssen YM, Heintz NH and Mossman BT:  Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells.  Cancer Res 55:2085-2089, 1995.
  6.  Mossman BT, Quinlan T and Janssen YMW:  Active oxygen species. In: Pathology of Human Environmental and Occupational Disease (JE Craighead, ed), Mosby Year-Book, Inc., St. Louis, pp. 347-357, 1995. 
  7.  Gee JBL and Mossman BT: Basic mechanisms in occupational lung disease including lung cancer and mesothelioma In: Occupational Lung Diseases (WKC Morgan and A Seaton, eds), 3rd Ed, WB Saunders, Orlando, pp. 191-221, 1995.
  8.  Mossman BT, Jimenez LA, BeruBe K, Quinlan T and Janssen YMW:  Possible mechanisms of crystalline silica-induced lung disease.  Appl Occup Environ Hyg 10:1115-1117, 1995.
  9. Mossman BT and Gee JBL:  Basic mechanisms in occupational lung diseases including lung cancer and mesothelioma. In:  Morgan K and Santon A, eds., Occupational Lung Diseases, 3rd edi., W. B. Saunders, Philadelphia, pp. 191-221, 1995.
  10.  Mossman BT, Mason R, McDonald JA and Gail DB:  Advances in molecular genetics, transgenic models, and gene therapy for the study of pulmonary diseases.  Am J Respir Crit Care Med 151:2065-2069, 1995.
  11.  BeruBe KA, Quinlan TR, Moulton G, Hemenway D, O'Shaughnessy P, Vacek P and Mossman BT:  Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos. Toxicol Appl Pharmacol 137:67-74, 1996.
  12. Treadwell MD, Mossman BT and Barchowsky A:  Increased neutrophil adherence to endothelial cells exposed to asbestos.  Toxicol Appl Pharmacol 139:62-70, 1996.
  13. BeruBe KA, Quinlan TR, Fung H, Magae J, Vacek P, Taatjes DJ, and Mossman BT:  Apoptosis is observed in mesothelial cells after exposure to crocidolite asbestos.  Am J Respir Cell Mol Biol 15:141-147, 1996.
  14. Mossman BT, Surinrut P, Brinton BT, Marsh JP, Heintz NH, Lindau-Shepard B, and Shaffer JB:  Transfection of a manganese-containing superoxide dismutase gene into hamster tracheal epithelial cells ameliorates asbestos-mediated cytotoxicity.  Free Radic Biol Med 21:125-131, 1996.
  15. Zanella CL, Posada J, Tritton TR and Mossman BT:  Asbestos causes stimulation of the ERK-1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor.  Cancer Res 56:5334-5338, 1996.
  16. Chen Q, Marsh J, Ames B, and Mossman B: Detection of 8-oxo-2'-deoxyguanosine, a marker of oxidative DNA damage, in culture medium from human mesothelial cells exposed to crocidolite asbestos. Carcinogenesis 17:2525-2527, 1996. 
  17. Mossman BT, Kamp DW and Weitzman SA: Mechanisms of carcinogenesis and clinical  features of asbestos-associated cancers. Cancer Invest 14:466-480, 1996.
  18. Fung H, Kow YW, Van Houten B, and Mossman BT:  Patterns of 8-hydroxydeoxyguanosine (8OHdG) formation in DNA and indications of oxidative stress in rat and human pleural mesothelial cells after exposure to crocidolite asbestos.  Carcinogenesis 18:101-108, 1997.
  19. Fung H, Quinlan TR, Janssen YMW, Timblin CR, Marsh JP, Heintz NH, Taatjes DJ, Vacek P, Jaken S, and Mossman BT:  Inhibition of protein kinase C (PKC) prevents asbestos-induced c-fos and c-jun protooncogene expression in mesothelial cells. Cancer Res 57:3101-3105, 1997.
  20. Janssen YMW, Driscoll KE, Howard B, Quinlan TR, Treadwell M, Barchowsky A, and Mossman BT:  Asbestos causes translocation of p65 protein and increases NF-?B DNA binding activity in rat lung epithelial and pleural mesothelial cells.  Am J Pathol 151:389-401, 1997.
  21. Goldberg JL, Zanella CL, Janssen YMW, Timblin CR, Jimenez LA, Vacek P, Taatjes DJ, and Mossman BT:  Novel cell imaging approaches show induction of apoptosis and proliferation in mesothelial cells by asbestos.  Am J Respir Cell Mol Biol 17:265-271, 1997.
  22. Janssen YMW, Matalon S, and Mossman BT:  Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS. Am J Physiol (Lung Cell & Mol Physiol) 273:L789-L796, 1997.
  23. Mossman BT, Faux S, Janssen Y, Jimenez LA, Timblin C, Zanella C, Goldberg J, Walsh E, Barchowsky A, and Driscoll K:  Cell signaling pathways elicited by asbestos.  Environ Health Perspect 105(Suppl. 5):1121-1125, 1997.
  24. Jimenez LA, Zanella C, Fung H, Janssen YMW, Vacek P, Charland C, Goldberg J, and Mossman BT:  Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2.  Am J Physiol (Lung Cell Mol Physiol) 273:L1029-L1035, 1997. 
  25. Mossman BT and Gee JB:  Asbestos-related cancer and the amphibole hypothesis. The hypothesis is still supported by scientists and scientific data [letter; comment]. Am J Publ Health 87:689-690; discussion 690-691, 1997.
  26. Davis WP, Janssen YMW, Mossman BT, and Taatjes DJ:  Simultaneous triple fluorescence detection of mRNA localization, nuclear DNA, and apoptosis in cultured cells using confocal laser scanning microscopy. Histochem Cell Biol 108:307-311, 1997. 
  27. Wylie AG, Skinner HC, Marsh J, Snyder H, Garzione C, Hodkinson D, Winters R, and Mossman BT:  Mineralogical features associated with cytotoxic and proliferative effects of fibrous talc and asbestos on rodent tracheal epithelial and pleural mesothelial cells. Toxicol Appl Pharmacol 147:143-150, 1997.
  28.  Janssen YMW, Timblin CR, Zanella CL, Jimenez LA, Mossman BT:  Induction of gene expression by environmental oxidants associated with inflammation, fibrogenesis, and carcinogenesis. In:  Oxidative Stress and Signal Transduction, HJ Forman, E Cadenas, eds., Chapman and Hall, New York, NY, pp. 387-414, 1997. 
  29.  Mossman BT, Taishi P, Quinlan T, Timblin C, BeruBé K, Marsh JP, Jimenez LA, Vacek P, Janssen YMW:  Molecular markers of cell proliferation and injury: correlations between in vitro observations and rodent inhalation studies using crocidolite and chrysotile asbestos. In: Correlations Between In Vitro and In Vivo Investigations in Inhalation Toxicology, Mohr U, Ed., ILSI Press, Washington, DC., pp. 172-181, 1997.
  30.  Alleman JE and Mossman BT:  Asbestos revisited. Scientific Amer. pp. 70-75, July, 1997. 
  31.  Timblin CR, Janssen YMW, Mossman BT:  Free radical mediated alterations of gene expression by xenobiotics. In:  Free Radical Toxicology, KB Wallace, ed., Taylor and Francis, Washington, DC., pp. 325-348, 1997.
  32.  Pache JC, Janssen YMW, Walsh ES, Quinlan TR, Zanella CL, Low, RB, Taatjes DJ, and Mossman BT:  Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers. Am J Pathol 152:333-340, 1998.
  33.  Mossman BT and Churg A:  State-of-the-Art:  Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med 157:1666-1680, 1998.
  34.  Fung H, Kow YW, Van Houten B, Taatjes DJ, Hatahet Z, Janssen YMW, Vacek P, Faux SP, and Mossman BT:  Asbestos increases mammalian major AP-endonuclease (APE) gene expression, protein levels and enzyme activity in rat pleural mesothelial cells. Cancer Res 58:189-194, 1998.
  35. BeruBe K, Mossman B, Quinlan T, and Taatjes D:  Diverse microscopy imaging techniques for studies of asbestos-induced lung disease. Microscopy & Analysis (March), pp. 13-15, 1998.
  36. Timblin CR, Janssen YMW, Goldberg JL, and Mossman BT:  GRP78, HSP72/73, and c-jun stress protein levels in lung epithelial cells exposed to asbestos, cadmium, or H2O2. Free Radic Biol Med 24:632-642, 1998.
  37. Quinlan TR, Hacker MP, Taatjes D, Timblin C, Goldberg J, Kimberley P, BeruBe KA, O'Shaughnessy P, Hemenway D, Torino J, Jimenez LA and Mossman BT:  Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models.  Free Radic Biol Med 24(5):778-788, 1998.
  38. Driscoll KE, Carter JM, Howard BW, Hassenbein D, Janssen YMW, and Mossman BT:  Crocidolite activates NF-kB and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochondrial-derived oxidants.  Environ. Health Perspect. 106(Suppl. 5):1171-1174, 1998.
  39. Janssen YMW, Driscoll KE, Timblin CR, Hassenbein D, and Mossman BT:  Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants. Environ Health Perspect 106(Suppl. 5):1191-1195, 1998.
  40. Timblin CR, Guthrie GD, Janssen YMW, Walsh ES, Vacek P, and Mossman BT:  Patterns of c-fos and c-jun proto-oncogene expression, apoptosis, and proliferation in rat pleural mesothelial cells exposed to erionite or asbestos fibers.  Toxicol Appl Pharmacol 151:88-97, 1998.
  41. Barchowsky A, Roussel RR, Krieser RJ, Mossman BT, and Treadwell MD:  Expression and activity of urokinase and its receptor in endothelial and pulmonary epithelial cells exposed to asbestos. Toxicol Appl Pharmacol 152:388-396, 1998.
  42. Timblin C, BeruBe K, Churg A, Driscoll K, Gordon T, Walsh E, Cummins AB, Vacek P, and Mossman B:  Ambient particulate matter causes activation of the c-jun kinase/stress-activated protein kinase cascade and DNA synthesis in lung epithelial cells. Cancer Res 58:4543-4547, 1998.
  43. Timblin CR, Janssen-Heininger Y, and Mossman BT:  Pulmonary reactions and mechanisms of toxicity of inhaled fibers, In: Toxicology of the Lung (DE Gardner, JD Crapo, and RO McClellan, eds.), Taylor & Francis, Washington DC, 3rd Ed, 1998.
  44. Mossman BT:  Effects on laboratory mammals and in vitro test systems, In: Environmental Health Criteria 203:  Chryostile Asbestos, International Programme on Chemical Safety, World Health Organization, pp. 69-102, Geneva, 1998.
  45. Driscoll K, Hassenbein D, Howard B, Carter J, Gauldie J, Janssen Y and Mossman B:  Cytokines, oxidative stress and inflammation. In:  Proceedings of the 6th International Inhalation Symposium "Relationships Between Respiratory Disease and Exposure to Air Pollution".
  46. Janssen YMW, Macara I, and Mossman BT:  Cooperativity between oxidants and tumor necrosis factor in the activation of NF-?B in lung epithelial cells:  requirement of Ras/mitogen activated protein kinases in the activation of NF-?B by oxidants. Am J Respir Cell Mol Biol 20:942-952, 1999.
  47. Zanella CL, Timblin CR, Cummins A, Jung M, Goldberg J, Raabe R, Tritton TR and Mossman BT:  Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos expression and apoptosis. Am J Physiol (Lung Cell Mol Physiol) 277:L684-L693, 1999.
  48. Robledo R and Mossman B:  Cellular and molecular mechanisms of asbestos-induced fibrosis. J. Cell. Physiol. 180:158-166, 1999.
  49. Poynter ME, Janssen-Heininger YMW, Buder-Hoffmann S, Taatjes DJ and Mossman BT:  Measurement of oxidant-induced signal transduction proteins using cell imaging.  Free Radic. Biol. Med. 27:1164-1172, 1999.
  50. Rahman Q, Abidi P, Afaq F, Schiffmann D, Mossman BT, Kamp DW, Athar M. Glutathione redox system in oxidative lung injury. Crit Rev Toxicol. 29(6):543-568, 1999.
  51. Robledo R and Mossman B:  Cellular and molecular mechanisms of asbestos-induced fibrosis. J Cell Physiol 180:158-166, 1999.
  52. Mossman BT:  Environmental Pathology:  New directions and opportunities:  Toxicol Pathol 27:180-186, 1999.
  53. Poynter ME, Janssen-Heininger YMW, Buder-Hoffmann S, Taatjes DJ and and Mossman BT:  Measurement of oxidant-induced signal transduction proteins using cell imaging. Free Radic. Biol. Med. 27:1164-1172, 1999. 
  54. Robledo RF, Buder-Hoffmann SA, Cummins AB, Walsh ES, Taatjes D and Mossman BT:  Increased phosphorylated ERK immunoreactivity associated with proliferative and morphologic lung alterations following chrysotile asbestos inhalation in mice.  Am. J. Pathol. 156:1307-1316, 2000.
  55. Shukla A, Timblin C, BeruBe K, Gordon T, McKinney W, Driscoll K, Vacek P, and Mossman BT:  Inhaled particulate matter causes expression of nuclear factor (NF)-kappaB-related genes and oxidant-dependent NF-kappaB activation in vitro. Am J Respir Cell Mol Biol. 23(2):182-187, 2000.
  56. Jung  M, Davis W, Taatjes D, Churg A, Mossman BT:  Asbestos and cigarette smoke cause increased in apoptosis in rat bronchiolar epithelium. Free Radic. Biol. Med. 28:1295-1299, 2000.
  57. Hessel PA, Gamble JF, Gee JBL, Gibbs G, Green FHY, Morgan WKC, and Mossman BT:  Silica, silicosis, and lung cancer:  a response to a recent working group report.   J Occup Environ Med. 42(7):704-720, 2000.
  58. Murthy SS, Shen T, De Rienzo A, Lee WC, Ferriola PC, Jhanwar SC, Mossman BT, Filmus J,Testa JR:   Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma. Oncogene. 19(3):410-416, 2000.
  59. Mossman BT:  Mechanisms of action of poorly soluble particulates in overload-related lung pathology.  Proceedings of the ILSI Workshop on the Relevance of the Rat Lung Response to Particle Overload for Human Risk Assessment, 23 March, 1998. Inhal Toxicol 12;101-108, 2000.
  60. Fukagawa N, Timblin C, Buder-Hoffmann S, and Mossman BT:  Strategies for evaluation of signaling pathways and transcription factors altered in aging. Antioxid Redox Signal. 2(3):379-389, 2000.
  61. Shukla A, Timblin CR, Hubbard AK, Bravman J, and Mossman BT:   Silica-induced activation of c-Jun-NH2-terminal amino kinases, protracted expression of the Activator Protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress.  Cancer Res. 61: 1791-1795, 2001.
  62. Buder-Hoffmann, Palmer C, Vacek P, Taatjes D and Mossman B:  Different accumulation of activated extracellular signal-regulated kinases (ERK 1/2) and role in cell-cycle alterations by epidermal growth factor, hydrogen peroxide, or asbestos in pulmonary epithelial cells. Am J Respir Cell Mol Biol. 64(4):405-413, 2001.
  63. Timblin C, Robledo R, Rincon M, Cummins A, Pfeiffer L and Mossman B:  Transgenic mouse models to determine the role of epidermal growth factor receptor (EGFR) in epithelial cell proliferation, apoptosis, and asbestosis.  Chest 120:22S-24S, 2001.
  64. Hubbard AK, Timblin CR, Rincon M, Mossman BT:  Use of transgenic luciferase reporter mice to determine activation of transcription factors and gene expression of fibrogenic particles.  Chest 120:24S-25S, 2001.
  65. Timblin CR, Janssen-Heininger Y, and Mossman BT:  Physical agents in human carcinogenesis. In:  WB Coleman & GJ Tsongalis, eds., Molecular Basis of Human Cancer, Humana Press, Inc., Totowa, NJ, pp 223-232, 2001.
  66. Johnson NF and Mossman BT:  Dose, dimension, durability and biopersistence of chrysotile asbestos.  The Canadian Mineralogist  Spec. Publ. 5: pp. 145-154, 2001.
  67. Shukla A, Timblin CR, Mossman BT and Hubbard A:  The role of free radicals in asbestos- and silica-induced fibrotic lung diseases.  In:  Environmental Stressors in Health and Disease (Oxidative Stress and Disease Series/7), (J. Fuchs and L Packer, eds.),  Marcel Dekker, Inc., pp. 185-202, 2001.
  68. Taatjes DJ, Palmer CJ, Pantano C, Buder-Hoffmann S, Cummins A and Mossman BT:  Laser-based microscopic approaches:  Application to cell signaling in environmental lung disease.  Biotechniques 31:880-894, 2001.
  69. Shi X, Ding M, Yucesoy B, Mossman B and Vallyathan V:  Diseases caused by silica:  Mechanisms of injury and disease development.  Int. Immunopharmacology (In Press, 2001).
  70. Manning CB, Vallyathan V, and Mossman BT:  Diseases caused by asbestos:  Mechanisms of injury and disease development.  Int. Immunopharmacology (In Press, 2001).
  71. Hubbard A, Timblin CR, Shukla A, Rincon M, and Mossman BT:  Activation of NF-kB-dependent gene expression by silica. Chest 2001 Jul;120(1 Suppl):24S-25S.
  72. BeruBe KA, Murphy SA, Jones TP, Timblin C, Hemenway D, Mossman BT and Richards RJ:  Characterisation of airborne particulate matter and related mechanisms of toxicity.  In:  J Ayres, R Maynard, R Richards, eds.  Air Pollution and Health, Vol. 4, Imperial College Press, London (In Press).
  73. Mossman BT, Hubbard A, Shukla A, and Timblin CR:  Role of mitogen activated protien kinases (MAPK), early response protooncogenes, and activator protein (AP-1) in cell signalling by asbestos.  Proceedings of the 7th International Meeting on Particle Toxicology. Inhal Toxicol (In Press).
  74. Fukagawa NK, Li M, Timblin CR and Mossman BT:  Modulation of cell injury and survival by high glucose and advancing age.  Free Radic. Biol. Med. (In Press), 2001.
  75. Lounsbury KM, Stern M, Jaken S, and Mossman BT:  Increased localization and substrate activation of protein kinase C? in lung epithelial cells following exposure to asbestos.  (Submitted)
  76. Vianale G, Mutti L, Timblin C, Berlanger I, MacPherson M, and Mossman BT:  Synergistic effects of onconase and extracellular signal-regulated kinase (ERK) inhibition on killing of human mesothelioma cells. (Submitted) 
Books/Series: 
  1.  Mossman BT and Begin RO (eds.): Effects of Mineral Dusts on Cells, NATO ASI Series H: Cell Biology, Springer-Verlag, Berlin, pp.1-470, 1989.
  2.  Guthrie GD, Jr, and Mossman BT (eds.): Health Effects of Mineral Dusts, Reviews in   Mineralogy, Vol. 28 (Series Editor: Paul H. Ribbe), Mineralogical Society of America, Washington, D.C., pp. 1-584, 1993.
  3.  Mossman BT:  Guest Editor.  Forum on “Signal Transduction by Oxidants:  Look who’s talking”.  Free Radic. Biol. Med. 28, 2000.
  4.  Taatjes & Mossman:  Cell Imaging Techniques (Methods in Molecular Biology), Humana Press, In Press.